Volume 34, Issue 5 (8-2026)
JSSU 2026, 34(5): 10271-10285 |
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Ethics code: IR.SSU.MEDICINE.REC.1402.420
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Vajihinejad M, Malakooti M, Moghimi M, Ekraminasab S. A Clinicopathological Evaluation of Gastrointestinal Lymphomas in patients Referred to Shahid Sadoughi Hospital (2018-2023). JSSU 2026; 34 (5) :10271-10285
URL: http://jssu.ssu.ac.ir/article-1-6606-en.html
URL: http://jssu.ssu.ac.ir/article-1-6606-en.html
Abstract: (15 Views)
Introduction: Gastrointestinal lymphomas (GILs) are among the most common forms of extranodal lymphoma and represent a heterogeneous group with respect to clinical presentation, anatomical site of involvement, and histopathological subtypes. Understanding the clinicopathological characteristics of this disease in different geographic regions may facilitate early diagnosis, appropriate treatment selection, and improved patient outcomes. Therefore, the present study was conducted to evaluate the demographic, clinical, and pathological characteristics of patients with gastrointestinal lymphoma.
Methods: This retrospective descriptive cross-sectional study was conducted on 62 patients with gastrointestinal lymphoma referred to the pathology Department of Shahid Sadoughi Hospital, Yazd, during 2018–2023. All eligible patients were enrolled using a census sampling method. Demographic characteristics, clinical manifestations, anatomical sites of involvement, and final pathological diagnoses were extracted from electronic health records and pathology archives. Data were analyzed using SpSS version 16. Quantitative variables were presented as mean ± standard deviation, and qualitative variables were reported as frequency and percentage. Fisher’s exact test was used to assess associations between variables, and a p-value <0.05 was considered statistically significant.
Results: The mean age of the patients was 46.26 ± 25.01 years. Among the 62 evaluated patients, 40 (64.52%) were female and 22 (35.48%) were male, with a male-to-female ratio of 1.8:1. The most common clinical manifestations were abdominal pain (48.39%), weight loss (38.71%), and anorexia (37.10%), respectively. Regarding the anatomical sites of involvement, the stomach was the most frequently affected site (24.19%), followed by the liver (17.74%) and pancreas (11.29%). Simultaneous involvement of two anatomical sites was observed in 8.07% of patients. Histopathologically, diffuse large B-cell lymphoma (DLBCL) was the most common subtype (41.93%), followed by B-cell lymphoma (16.13%) and Burkitt lymphoma (9.68%). Significant associations were observed between clinical symptoms, including anorexia, dysphagia, odynophagia, and nausea/vomiting, and the anatomical site of involvement (p<0.05). A significant association was also found between patient age and pathological diagnosis (P=0.005); however, sex was not significantly associated with either the anatomical site of involvement or pathological subtype.
Conclusion: The findings of this study demonstrated that gastrointestinal lymphoma was more prevalent among males, with the stomach being the most commonly involved site. Diffuse large B-cell lymphoma (DLBCL) was identified as the predominant pathological subtype, and abdominal pain was the most frequent clinical manifestation. Recognition of these demographic, clinical, and pathological patterns may contribute to early diagnosis, treatment decision-making, and improved patient management. Given the diagnostic challenges associated with this disease, further large-scale multicenter studies are recommended to optimize diagnostic and therapeutic approaches.
Methods: This retrospective descriptive cross-sectional study was conducted on 62 patients with gastrointestinal lymphoma referred to the pathology Department of Shahid Sadoughi Hospital, Yazd, during 2018–2023. All eligible patients were enrolled using a census sampling method. Demographic characteristics, clinical manifestations, anatomical sites of involvement, and final pathological diagnoses were extracted from electronic health records and pathology archives. Data were analyzed using SpSS version 16. Quantitative variables were presented as mean ± standard deviation, and qualitative variables were reported as frequency and percentage. Fisher’s exact test was used to assess associations between variables, and a p-value <0.05 was considered statistically significant.
Results: The mean age of the patients was 46.26 ± 25.01 years. Among the 62 evaluated patients, 40 (64.52%) were female and 22 (35.48%) were male, with a male-to-female ratio of 1.8:1. The most common clinical manifestations were abdominal pain (48.39%), weight loss (38.71%), and anorexia (37.10%), respectively. Regarding the anatomical sites of involvement, the stomach was the most frequently affected site (24.19%), followed by the liver (17.74%) and pancreas (11.29%). Simultaneous involvement of two anatomical sites was observed in 8.07% of patients. Histopathologically, diffuse large B-cell lymphoma (DLBCL) was the most common subtype (41.93%), followed by B-cell lymphoma (16.13%) and Burkitt lymphoma (9.68%). Significant associations were observed between clinical symptoms, including anorexia, dysphagia, odynophagia, and nausea/vomiting, and the anatomical site of involvement (p<0.05). A significant association was also found between patient age and pathological diagnosis (P=0.005); however, sex was not significantly associated with either the anatomical site of involvement or pathological subtype.
Conclusion: The findings of this study demonstrated that gastrointestinal lymphoma was more prevalent among males, with the stomach being the most commonly involved site. Diffuse large B-cell lymphoma (DLBCL) was identified as the predominant pathological subtype, and abdominal pain was the most frequent clinical manifestation. Recognition of these demographic, clinical, and pathological patterns may contribute to early diagnosis, treatment decision-making, and improved patient management. Given the diagnostic challenges associated with this disease, further large-scale multicenter studies are recommended to optimize diagnostic and therapeutic approaches.
Keywords: Lymphoma, Non-Hodgkin, Gastrointestinal Neoplasms, Diffuse Large B-Cell Lymphoma, Clinical pathology..
Type of Study: Original article |
Subject:
Pathology
Received: 2025/12/29 | Accepted: 2026/05/6 | Published: 2026/08/6
Received: 2025/12/29 | Accepted: 2026/05/6 | Published: 2026/08/6
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