1. 1- Fürstenberger G, Epp N, Eckl K-M, Hennies HC, Jørgensen C, Hallenborg P. Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation. Prostaglandins Other lipid Med 2007; 82(1-4): 128-34.
2. 2- Kuhn H, Banthiya S, van Leyen K. Mammalian lipoxygenases and their biological relevance. Biochimica et Biophysica Acta 2015; 1851(4): 308-30.
3. 3- Mashima R, Okuyama T. The role of lipoxygenases in pathophysiology; new insights and future perspectives. Redox Biol 2015; 6: 297-310.
4. 4- Schneider C, Pratt DA, Porter NA, Brash AR. Control of oxygenation in lipoxygenase and cyclooxygenase catalysis. Chemistry & Bio 2007; 14(5): 473-88.
5. 5- Mattsson N, Yaong M, Rosengren L, Blennow K, Månsson JE, Andersen O. Elevated cerebrospinal fluid levels of prostaglandin E2 and 15‐(S)‐hydroxyeicosatetraenoic acid in multiple sclerosis. J Intern Med 2009; 265(4): 459-64.
6. 6- Ackermann JA, Hofheinz K, Zaiss MM, Krönke G. The double-edged role of 12/15-lipoxygenase during inflammation and immunity. Biochimica et Biophysica Acta (BBA)-Mol Cell Biol Lipids 2017; 1862(4): 371-81.
7. 7- Kühn H, O’Donnell VB. Inflammation and immune regulation by 12/15-lipoxygenases. Prog lipid Res 2006; 45(4): 334-56.
8. 8- Uderhardt S, Krönke G. 12/15-lipoxygenase during the regulation of inflammation, immunity, and self-tolerance. J Mol Med 2012; 90(11): 1247-56.
9. 9- Larsen JS, Acosta EP. Leukotriene-receptor antagonists and 5-lipoxygenase inhibitors in asthma. Annals Pharmaco 1993; 27(7-8): 898-903.
10. 10- Blaho VA, Zhang Y, Hughes-Hanks JM, Brown CR. 5-Lipoxygenase–Deficient Mice Infected with Borrelia burgdorferi Develop Persistent Arthritis. J Immunology 2011; 186(5): 3076-84.
11. 11- Steinhilber D, Fischer AS, Metzner J, Steinbrink SD, Roos J, Ruthardt M, et al. 5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumorigenesis. Front Pharm 2010; 1: 143.
12. 12- Park SW, Heo DS, Sung MW. The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells. Cell Oncol 2012; 35(1): 1-8.
13. 13- Cyrus T, Witztum JL, Rader DJ, Tangirala R, Fazio S, Linton MF, et al. Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice. J Clin Invest 1999; 103(11): 1597-604.
14. 14- Harats D, Shaish A, George J, Mulkins M, Kurihara H, Levkovitz H, et al. Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor–deficient mice. Arteriosclerosis, Thrombosis, Vascular Biol 2000; 20(9): 2100-5.
15. 15- Kelavkar U, Glasgow W, Eling TE. The effect of 15-lipoxygenase-1 expression on cancer cells. Current urology reports 2002; 3(3): 207-14.
16. 16- Schewe T. 15-lipoxygenase-1: a prooxidant enzyme. Biol Chem 2002; 383(3-4): 365-74.
17. 17- Rothe T, Gruber F, Uderhardt S, Ipseiz N, Rössner S, Oskolkova O, et al. 12/15-lipoxygenase–mediated enzymatic lipid oxidation regulates DC maturation and function. J Clin Invest 2015; 125(5): 1944-54.
18. 18- Sultana C, Shen Y, Rattan V, Kalra VK. Lipoxygenase metabolites induced expression of adhesion molecules and transendothelial migration of monocyte‐like HL‐60 cells is linked to protein kinase C activation. J Cell Physiol 1996; 167(3): 477-87.
19. 19- Rubab K, Abbasi MA, Siddiqui SZ, Ashraf M, Shaukat A, Ahmad I, et al. S-Alkylated/aralkylated 2-(1H-indol-3-yl-methyl)-1, 3, 4-oxadiazole-5-thiol derivatives. 2. Anti-bacterial, enzymeinhibitory and hemolytic activities. Tropical J Pharma Res 2016; 15(7): 1525-33.
20. 20- Nafeesa K, Abbasi MA, Siddiqui SZ, Rasool S, Shah SA. Synthesis, characterization and pharmacological evaluation of different 1, 3, 4-oxadiazole and acetamide derivatives of ethyl nipecotate. Bulletin of Faculty of Pharmacy, Cairo Uni 2017; 55(2): 333-43. [Persian]
21. 21- Sattar A, Aziz-ur-Rehman, Abbasi MA, Siddiqui SZ, Rasool S, Ahmad I. Synthesis of some novel enzyme inhibitors and antibacterial agents derived from 5-(1-(4-tosyl) piperidin-4-yl)-1, 3, 4-oxadiazol-2-thiol. Brazilian J Pharmaceutical Sci 2016; 52(1): 77-85.
22. 22- Pelcman B, Sanin A, Nilsson P, No K, Schaal W, Öhrman S, et al. 3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1. Bioorganic & Med Chem Letters 2015; 25(15): 3024-9.
23. 23- Cai H, Huang X, Xu S, Shen H, Zhang P, Huang Y, et al. Discovery of novel hybrids of diaryl-1, 2, 4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy. Eur J Med Chem 2016; 108: 89-103.
24. 24- Jiang B, Huang X, Yao H, Jiang J, Wu X, Jiang S, et al. Discovery of potential anti-inflammatory drugs: diaryl-1, 2, 4-triazoles bearing N-hydroxyurea moiety as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase. Organic Biomol Chem 2014; 12(13): 2114-27.
25. 25- Mohamed MS, Mansour YE, Amin HK, El-Araby ME. Molecular modelling insights into a physiologically favourable approach to eicosanoid biosynthesis inhibition through novel thieno [2, 3-b] pyridine derivatives. J Enzyme Inhib Med Chem 2018; 33(1): 755-67.
26. 26- Aliabadia A, Mohammadi-Farania A, Roodabehb S, Ahmadia F. Synthesis and Biological Evaluation of N-(5-(pyridin-2-yl)-1, 3, 4-thiadiazol-2-yl) benzamide Derivatives as Lipoxygenase Inhibitor with Potential Anticancer Activity. Iran J Pharm Res 2017; 16(1): 165-72. [Persian]
27. 27- Li Y, Chen SH, Ou TM, Tan JH, Li D, Gu LQ, Huang ZS. Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase. Bioorg Med Chem 2011; 19(6): 2074-83.
28. 28- El-Din MM, El-Gamal MI, Abdel-Maksoud MS, Yoo KH, Oh CH. Synthesis and broad-spectrum antiproliferative activity of diarylamides and diarylureas possessing 1, 3, 4-oxadiazole derivatives. Bioorg Med Chem 2015; 25(8): 1692-9.
29. 29- Tan TMC, Chen Y, Kong Kh, Bai J, Li Y, Lim SG, et al. Synthesis and the biological evaluation of 2-benzenesulfonylalkyl-5-substituted-sulfanyl-[1, 3, 4]-oxadiazoles as potential anti-hepatitis B virus agents. Antiviral Res 2006; 71(1): 7-14.
30. 30- Zhang K, Wang P, Xuan LN, Fu XY, Jing F, Li S, et al. Synthesis and antitumor activities of novel hybrid molecules containing 1, 3, 4-oxadiazole and 1, 3, 4-thiadiazole bearing Schiff base moiety. Bioorg Med Chem letters 2014; 24(22): 5154-6.
31. 31- Kumar D, Sundaree S, Johnson EO, Shah K. An efficient synthesis and biological study of novel indolyl-1, 3, 4-oxadiazoles as potent anticancer agents. Bioorg Med Chem letters 2009; 19(15): 4492-4.
32. 32- Omar FA, Mahfouz N, Rahman M. Design, synthesis and antiinflammatory activity of some 1, 3, 4-oxadiazole derivatives. Eur J Med Chem 1996; 31(10): 819-25.
33. 33- Abel S, Russell D, Whitlock LA, Ridgway CE, Nedderman AN, Walker DK. Assessment of the absorption, metabolism and absolute bioavailability of maraviroc in healthy male subjects. Br J Clin Pharmacol 2008; 65: 60-7.
34. 34- Torriani FJ, Rodriguez-Torres M, Rockstroh JK, Lissen E, Gonzalez-García J, Lazzarin A, et al. Peginterferon Alfa-2a plus ribavirin for chronic hepatitis C virus infection in HIV-infected patients. New England J Med 2004; 351(5): 438-50.
35. 35- Turan-Zitouni G, Kaplancıklı ZA, Yıldız MT, Chevallet P, Kaya D. Synthesis and antimicrobial activity of 4-phenyl/cyclohexyl-5-(1-phenoxyethyl)-3-[N-(2-thiazolyl) acetamido] thio-4H-1, 2, 4-triazole derivatives. Eur J Med Chem 2005; 40(6): 607-13.
36. 36- Tehranchian S, Akbarzadeh T, Fazeli MR, Jamalifar H, Shafiee A. Synthesis and antibacterial activity of 1-[1, 2, 4-triazol-3-yl] and 1-[1, 3, 4-thiadiazol-2-yl]-3-methylthio-6, 7-dihydrobenzo [c] thiophen-4 (5H) ones. Bioorg Med Chem Lett 2005; 15(4): 1023-5.[Persian]
37. 37- Herbrecht R, Denning DW, Patterson TF, Bennett JE, Greene RE, Oestmann JW, et al. Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. New England J Med 2002; 347(6): 408-15.
38. 38- Akbarzadeh T, Tabatabai SA, Khoshnoud MJ, Shafaghi B, Shafiee A. Design and synthesis of 4H-3-(2-phenoxy) phenyl-1, 2, 4-triazole derivatives as benzodiazepine receptor agonists. Bioorg Med Chem 2003; 11(5): 769-73. [Persian]
39. 39- Tozkoparan B, Küpeli E, Yeşilada E, Ertan M. Preparation of 5-aryl-3-alkylthio-l, 2, 4-triazoles and corresponding sulfones with antiinflammatory–analgesic activity. Bioorg Med Chem 2007; 15(4): 1808-14.
40. 40- Salgın-Gökşen U, Gökhan-Kelekçi N, Göktaş Ö, Köysal Y, Kılıç E, Işık Ş, et al. 1-Acylthiosemicarbazides, 1, 2, 4-triazole-5 (4H)-thiones, 1, 3, 4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: synthesis, analgesic-anti-inflammatory and antimicrobial activities. Bioorg Med Chem 2007; 15(17): 5738-51.
41. 41- Bhaskaruni SV, Maddila S, Gangu KK, Jonnalagadda SB. A Review on multi-component green synthesis of N-containing heterocycles using mixed oxides as heterogeneous catalysts. Arabian J Chem 2017.
42. 42- Amir M, Kumar H, Javed S. Condensed bridgehead nitrogen heterocyclic system: Synthesis and pharmacological activities of 1, 2, 4-triazolo-[3, 4-b]-1, 3, 4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid. Eur J Chem 2008; 43(10): 2056-66.
43. 43- Navidpour L, Shafaroodi H, Abdi K, Amini M, Ghahremani MH, Dehpour AR, et al. Design, synthesis, and biological evaluation of substituted 3-alkylthio-4, 5-diaryl-4H-1, 2, 4-triazoles as selective COX-2 inhibitors. Bioorg Med Chem 2006; 14(8): 2507-17. [Persian]
44. 44- Helal M, El-Awdan S, Salem M, Abd-Elaziz T, Moahamed Y, El-Sherif A, et al. Synthesis, biological evaluation and molecular modeling of novel series of pyridine derivatives as anticancer, anti-inflammatory and analgesic agents. Spectrochim Acta A Mol Biomol Spectrosc 2015; 135: 764-73.
45. 45- Hill MD. Recent strategies for the synthesis of pyridine derivatives. Chemistry–A Eur J 2010; 16(40): 12052-62.
46. 46- Bernardino AMR, de Azevedo AR, da Silva Pinheiro LC, Borges JC, Carvalho VL, Miranda MD, et al. Synthesis and antiviral activity of new 4-(phenylamino)/4-[(methylpyridin-2-yl) amino]-1-phenyl-1H-pyrazolo [3, 4-b] pyridine-4-carboxylic acids derivatives. Med Chem Res 2007; 16(7-9): 352-69.
47. 47- Gaonkar S, Rai KL, Prabhuswamy B. Synthesis of novel 3-[5-ethyl-2-(2-phenoxy-ethyl)-pyridin]-5-substituted isoxazoline libraries via 1, 3-dipolar cycloaddition and evaluation of antimicrobial activities. Med Chem Res 2007; 15(7-8): 407-17.
48. 48- Patel NB, Patel HR. Synthesis and pharmacological studies of 5-ethyl pyridin-2-ethanol analogs derivatives. ARKIVOC 2009; 12: 302-21.
49. 49- Xu M, Wang Y, Yang F, Wu C, Wang Z, Ye B, et al. Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs. Bioorg Med Chem Lett 2018; 28(4): 606-11.
50. 50- Loso MR, Benko Z, Buysse A, Johnson TC, Nugent BM, Rogers RB, et al. SAR studies directed toward the pyridine moiety of the sap-feeding insecticide sulfoxaflor (Isoclast™ active). Bioorg Med Chem 2016; 24(3): 378-82.
51. 51- Ng HP, Buckman BO, Eagen KA, Guilford WJ, Kochanny MJ, Mohan R, et al. Design, synthesis, and biological activity of novel factor Xa inhibitors: 4-aryloxy substituents of 2, 6-diphenoxypyridines. Bioorg Med Chem 2002; 10(3): 657-66.
52. 52- Chao H, Turdi H, Herpin TF, Roberge JY, Liu Y, Schnur DM, et al. Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists. J Med Chem 2013; 56(4): 1704-14.
53. 53- Markley LD, Tong YC, Dulworth JK, Steward DL, Goralski CT, Johnston H, et al. Antipicornavirus activity of substituted phenoxybenzenes and phenoxypyridines. J Med Chem 1986; 29(3): 427-33.
54. 54- Song X, Chen W, Lin L, Ruiz CH, Cameron MD, Duckett DR, et al. Synthesis and SAR of 2-phenoxypyridines as novel c-Jun N-terminal kinase inhibitors. Bioorg Med Chem lett 2011; 21(23): 7072-5.
55. 55- Pavia MR, Taylor CP, Hershenson FM, Lobbestael SJ, Butler DE. 3-Phenoxypyridine 1-oxides as anticonvulsant agents. J Med Chem 1988; 31(4): 841-7.
56. 56- Malterud KE, Rydland KM. Inhibitors of 15-lipoxygenase from orange peel. J Agric Food Chem 2000; 48(11): 5576-80.
57. 57- Trott O, Olson AJ. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading. J Computational Chem 2010; 31(2): 455-61.
58. 58- Sanner MF. Python: a programming language for software integration and development. J Mol Graph Model 1999; 17(1): 57-61.
59. 59- O'Boyle NM, Banck M, James CA, Morley C, Vandermeersch T, Hutchison GR. Open Babel: An open chemical toolbox. J Chem Inf 2011; 3: 33.
60. 60-Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE. UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem 2004; 25(13):1605-12.