Volume 33, Issue 10 (2-2026)
JSSU 2026, 33(10): 9495-9508 |
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Sharifi Z, Kaki A. Investigation of the Changes in CXCL-14 and EPDR1 Gene Expression in Response to Aerobic Exercise in an Induced Obesity Animal Model. JSSU 2026; 33 (10) :9495-9508
URL: http://jssu.ssu.ac.ir/article-1-6490-en.html
URL: http://jssu.ssu.ac.ir/article-1-6490-en.html
Abstract: (7 Views)
Introduction: The diminished functionality of brown adipose tissue (BAT), a critical component for energy homeostasis, thermogenesis, and metabolic equilibrium, is intrinsically linked to obesity. Within BAT, the batokines CXCL-14 and EPDR1 are instrumental in orchestrating immune and metabolic processes. Accordingly, this study endeavor sought to investigate the changes in of CXCL-14 and EPDR1 gene expression patterns induced by aerobic exercise in a rodent model of diet-induced obesity.
Methods: This experimental study involved thirty-two male Wistar rats, which were subsequently divided into two groups: standard diet and high-fat diet containing fructose. Following a 24-week period designed to induce obesity, the animals were allocated into three subgroups: a control, high-fat diet, and high-fat diet group that also underwent aerobic exercise. Aerobic training was performed on a treadmill for 8 weeks. At the end of the intervention, the expression of CXCL-14 and EPDR1 genes was measured using Real-Time PCR. One-way ANOVA followed by Tukey’s post hoc test was applied for statistical analysis.
Results: The findings showed that a high-fat diet with fructose significantly reduced the expression of CXCL-14 and EPDR1 compared to the control group (P<0.001). Conversely, the implementation of aerobic exercise demonstrated a statistically significant increase in the expression of these genes compared to the high-fat diet group (P<0.05). Moreover, significant improvements in anthropometric indices and lipid profile were observed in the exercise group.
Conclusion: Aerobic physical exercise, by upregulating CXCL-14 and EPDR1, improves the metabolic and anti-inflammatory functions of adipose tissue in obesity. This mechanism is accompanied by the remodeling and functional enhancement of adipose tissue, particularly BAT; therefore, aerobic exercise can be considered an effective approach for preventing and alleviating obesity-related complications.
Methods: This experimental study involved thirty-two male Wistar rats, which were subsequently divided into two groups: standard diet and high-fat diet containing fructose. Following a 24-week period designed to induce obesity, the animals were allocated into three subgroups: a control, high-fat diet, and high-fat diet group that also underwent aerobic exercise. Aerobic training was performed on a treadmill for 8 weeks. At the end of the intervention, the expression of CXCL-14 and EPDR1 genes was measured using Real-Time PCR. One-way ANOVA followed by Tukey’s post hoc test was applied for statistical analysis.
Results: The findings showed that a high-fat diet with fructose significantly reduced the expression of CXCL-14 and EPDR1 compared to the control group (P<0.001). Conversely, the implementation of aerobic exercise demonstrated a statistically significant increase in the expression of these genes compared to the high-fat diet group (P<0.05). Moreover, significant improvements in anthropometric indices and lipid profile were observed in the exercise group.
Conclusion: Aerobic physical exercise, by upregulating CXCL-14 and EPDR1, improves the metabolic and anti-inflammatory functions of adipose tissue in obesity. This mechanism is accompanied by the remodeling and functional enhancement of adipose tissue, particularly BAT; therefore, aerobic exercise can be considered an effective approach for preventing and alleviating obesity-related complications.
Type of Study: Original article |
Subject:
Exercise Physiology
Received: 2025/08/4 | Accepted: 2026/02/4 | Published: 2026/02/4
Received: 2025/08/4 | Accepted: 2026/02/4 | Published: 2026/02/4
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