Volume 33, Issue 9 (12-2025)
JSSU 2025, 33(9): 9409-9418 |
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Naderi A, Saremi A, Afarinesh Khaki M R. 12 Weeks of Endurance and Resistance Exercise on Acetylcholine Levels and Pain Threshold of Male Alzheimer Rat. JSSU 2025; 33 (9) :9409-9418
URL: http://jssu.ssu.ac.ir/article-1-6488-en.html
URL: http://jssu.ssu.ac.ir/article-1-6488-en.html
Abstract: (31 Views)
Introduction: Alzheimer's is among the most prevalent neurodegenerative diseases associated with cognitive disorders, and behavioral changes. Exercise can be an important approach to enhance Alzheimer's complications, although its physiological mechanisms remain largely unclear. The aim of this study was to compare twelve weeks of endurance and resistance exercise on acetylcholine levels and pain thresholds in male Alzheimer’s mice.
Methods: In this experimental study, 40 male Wistar Rat heads were randomly divided into 4 groups for Alzheimer's induction, with 8 mg of trimethyltin chloride administered via injection into the peritoneum for each kilogram of weight of the mouse. Endurance training involved swimming in water. Resistance training was performed by having the mice climb while weights attached to their tails from the ladder. Following 12 weeks of training, acetylcholine levels and pain thresholds were assessed. The one-way ANOVA test and the Tukey’s tracking test were employed to analyze the data at the meaningful level P≤0/05 using the SPSS16 software.
Results: Findings indicated that following the intervention period, acetylcholine levels in the endurance training group were significantly higher than in the resistance training group (P=0/02) , the Alzheimer's control group (P=0/02) and the healthy control group (P=0/05). The pain threshold was significant in the endurance training group compared to the Alzheimer's control group (P=0/05) and the healthy control group (P=0/05), as well as the resistance training group (P=0/06).
Conclusion: It was observed that in both endurance and resistance training, acetylcholine levels and pain thresholds increase in male Alzheimer's rats, although improvement and effectiveness are more evident in the endurance training program.
Methods: In this experimental study, 40 male Wistar Rat heads were randomly divided into 4 groups for Alzheimer's induction, with 8 mg of trimethyltin chloride administered via injection into the peritoneum for each kilogram of weight of the mouse. Endurance training involved swimming in water. Resistance training was performed by having the mice climb while weights attached to their tails from the ladder. Following 12 weeks of training, acetylcholine levels and pain thresholds were assessed. The one-way ANOVA test and the Tukey’s tracking test were employed to analyze the data at the meaningful level P≤0/05 using the SPSS16 software.
Results: Findings indicated that following the intervention period, acetylcholine levels in the endurance training group were significantly higher than in the resistance training group (P=0/02) , the Alzheimer's control group (P=0/02) and the healthy control group (P=0/05). The pain threshold was significant in the endurance training group compared to the Alzheimer's control group (P=0/05) and the healthy control group (P=0/05), as well as the resistance training group (P=0/06).
Conclusion: It was observed that in both endurance and resistance training, acetylcholine levels and pain thresholds increase in male Alzheimer's rats, although improvement and effectiveness are more evident in the endurance training program.
Type of Study: Original article |
Subject:
Exercise Physiology
Received: 2025/08/3 | Accepted: 2025/09/15 | Published: 2025/12/6
Received: 2025/08/3 | Accepted: 2025/09/15 | Published: 2025/12/6
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