Volume 33, Issue 3 (6-2025)
JSSU 2025, 33(3): 8860-8870 |
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Ethics code: IR.IAU.PIAU.R.1400.010
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Salehi S S, Eizadi M, Sedaghaty S, Kazemzadeh Y, Mirzayan Shanjani S. Improvement of Fasting Glucose in Response to Resistance Training with Emphasis on the Expression of Hepatic PGC1α and HNF4α Genes in Type 2 Diabetic Rats. JSSU 2025; 33 (3) :8860-8870
URL: http://jssu.ssu.ac.ir/article-1-6354-en.html
URL: http://jssu.ssu.ac.ir/article-1-6354-en.html
Sayed Sadegh Salehi 
, Mojtaba Eizadi * , Saeid Sedaghaty , Yaser Kazemzadeh , Sanaz Mirzayan Shanjani
, Mojtaba Eizadi * , Saeid Sedaghaty , Yaser Kazemzadeh , Sanaz Mirzayan Shanjani
Abstract: (54 Views)
Introduction: Genetic studies have supported the importance of hepatic glucose release in hyperglycemia among individuals with type 2 diabetes. This study investigated the effect of 6 weeks of resistance training on hepatocytes genes PGC1α and HNF4α expression as well as fasting glucose levels in rats with type 2 diabetes (T2D).
Methods: This experimental study involved 21 male Wistar rats made obese by a 6-week high-fat diet. Subsequently, T2D was induced in 14 rats through STZ administration via intraperitoneal injection. Finally, the observed rats were divided into 3 groups (n=7): 1) non-diabetes, 2) diabetic control, 3) resistant to diabetic. The rats in the resistance group were completed resistance training for six weeks (5 times a week) by climbing a ladder while applying resistance. The control obese and control T2D groups did not participate in the resistance training. Forty-eight hours following the prolonged exercise session, hepatocytes genes PGC1α and HNF4α expression, along with serum insulin, glucose, and insulin resistance, was analyzed using One-Way ANOVA and Tukey post hoc test across different groups.
Results: T2D induction led to significant decrease in insulin levels and an increase in fasting glucose, alongside increased insulin resistance and hepatocytes genes PGC1α and HNF4α expression when compared to non-diabetes rats. Resistance training resulted in a significant increase in serum insulin (p = 0.043) and a decrease in fasting glucose (p = 0.001), insulin resistance (p = 0.001) and hepatocytes HNF4α expression (p = 0.001), compared to the control diabetic group.
Conclusion: Six weeks of resistance training resulted in a reduction in fasting glucose, and this improvement may be linked to a decrease in HNF4α expression and insulin resistance resulting from the resistance training.
Methods: This experimental study involved 21 male Wistar rats made obese by a 6-week high-fat diet. Subsequently, T2D was induced in 14 rats through STZ administration via intraperitoneal injection. Finally, the observed rats were divided into 3 groups (n=7): 1) non-diabetes, 2) diabetic control, 3) resistant to diabetic. The rats in the resistance group were completed resistance training for six weeks (5 times a week) by climbing a ladder while applying resistance. The control obese and control T2D groups did not participate in the resistance training. Forty-eight hours following the prolonged exercise session, hepatocytes genes PGC1α and HNF4α expression, along with serum insulin, glucose, and insulin resistance, was analyzed using One-Way ANOVA and Tukey post hoc test across different groups.
Results: T2D induction led to significant decrease in insulin levels and an increase in fasting glucose, alongside increased insulin resistance and hepatocytes genes PGC1α and HNF4α expression when compared to non-diabetes rats. Resistance training resulted in a significant increase in serum insulin (p = 0.043) and a decrease in fasting glucose (p = 0.001), insulin resistance (p = 0.001) and hepatocytes HNF4α expression (p = 0.001), compared to the control diabetic group.
Conclusion: Six weeks of resistance training resulted in a reduction in fasting glucose, and this improvement may be linked to a decrease in HNF4α expression and insulin resistance resulting from the resistance training.
Keywords: Type 2 Diabetes, Resistance Exercise, Gluconeogenic Gene Expression, Hepatic Glucose Release.
Type of Study: Original article |
Subject:
Exercise Physiology
Received: 2024/12/17 | Accepted: 2024/12/22 | Published: 2025/06/5
Received: 2024/12/17 | Accepted: 2024/12/22 | Published: 2025/06/5
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