Volume 32, Issue 11 (2-2025)
JSSU 2025, 32(11): 8414-8424 |
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Shamsi Z, Taheri Kalani A, Nikseresht M, Bakhtiari Dehbalaei1 S, Shamsi L. Comparison the Effect of Continuous and Interval Aerobic Training on IL-1 and TNF-α Expression in Cerebellum of Parkinson's Model Rats. JSSU 2025; 32 (11) :8414-8424
URL: http://jssu.ssu.ac.ir/article-1-6282-en.html
URL: http://jssu.ssu.ac.ir/article-1-6282-en.html
Zahra Shamsi 
, Abdolhossein Taheri Kalani * , Mahmoud Nikseresht , Somayeh Bakhtiari Dehbalaei1 , Leyla Shamsi
, Abdolhossein Taheri Kalani * , Mahmoud Nikseresht , Somayeh Bakhtiari Dehbalaei1 , Leyla Shamsi
Abstract: (19 Views)
Introduction: In Parkinson's disease, the balance between Pro-inflammatory and anti-inflammatory cytokines is disturbed, causing chronic neuroinflammation. The aim of present study was to compare the effects of continuous and interval aerobic training on the expression of interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α) in cerebellum of Parkinson's model rats.
Methods: In this experimental study, 28 adult male Wistar rats (weighting 180-250 gr) were randomly divided into four groups (n=7 each): control, Parkinson, Parkinson+ continuous training, and Parkinson+ interval training. Rotenone was utilized to induce Parkinson's in rats. The continuous training lasted between 15 to 40 minutes, while the interval training consisted of two to six sets of running on the treadmill at a speed of 10- 20 meters per minute for six weeks and five sessions per week. At the end of the intervention, the levels of IL-1 and TNF-α in the cerebellum tissue were assessed by Bradford method. The data were analyzed using one-way analysis of variance (ANOVA), followed by post hoc LSD test, utilizing SPSS version 16 software, with a significant level set at P<0.05.
Results: The levels of IL-1 and TNF-α in the cerebellar tissue of the control group were significantly lower (P=0.0001) compared to the other groups, and in the Parkinson's group, they were significantly higher than the Parkinson's+ continuous training and Parkinson's+ interval training groups (both; P=0.0001). There was no significant difference in IL-1 levels between the two training groups (P=0.062); nontheless, interval training significantly reduced the level of TNF-α compared to continuous training (P=0.007).
Conclusion: Based on these findings, interval aerobic training is a more efficient method in modulating pro-inflammatory cytokines in the cerebellum of Parkinson's model rats compared to continuous training, which can slow down the progression of the disease.
Methods: In this experimental study, 28 adult male Wistar rats (weighting 180-250 gr) were randomly divided into four groups (n=7 each): control, Parkinson, Parkinson+ continuous training, and Parkinson+ interval training. Rotenone was utilized to induce Parkinson's in rats. The continuous training lasted between 15 to 40 minutes, while the interval training consisted of two to six sets of running on the treadmill at a speed of 10- 20 meters per minute for six weeks and five sessions per week. At the end of the intervention, the levels of IL-1 and TNF-α in the cerebellum tissue were assessed by Bradford method. The data were analyzed using one-way analysis of variance (ANOVA), followed by post hoc LSD test, utilizing SPSS version 16 software, with a significant level set at P<0.05.
Results: The levels of IL-1 and TNF-α in the cerebellar tissue of the control group were significantly lower (P=0.0001) compared to the other groups, and in the Parkinson's group, they were significantly higher than the Parkinson's+ continuous training and Parkinson's+ interval training groups (both; P=0.0001). There was no significant difference in IL-1 levels between the two training groups (P=0.062); nontheless, interval training significantly reduced the level of TNF-α compared to continuous training (P=0.007).
Conclusion: Based on these findings, interval aerobic training is a more efficient method in modulating pro-inflammatory cytokines in the cerebellum of Parkinson's model rats compared to continuous training, which can slow down the progression of the disease.
Type of Study: Original article |
Subject:
Exercise Physiology
Received: 2024/09/18 | Accepted: 2024/11/24 | Published: 2025/02/3
Received: 2024/09/18 | Accepted: 2024/11/24 | Published: 2025/02/3
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