Volume 32, Issue 2 (5-2024)
JSSU 2024, 32(2): 7505-7515 |
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Shiri M, Fadai Chafi M R, Gholamrezaei S. Investigating the Effect of Resistance-Aerobic Training on the Absorption and Resorption Biomarkers of Bone Tissue in Young, Adult and Elderly Male Rats. JSSU 2024; 32 (2) :7505-7515
URL: http://jssu.ssu.ac.ir/article-1-6141-en.html
URL: http://jssu.ssu.ac.ir/article-1-6141-en.html
Abstract: (140 Views)
Introduction: Exercise training is likely to be a non-pharmacological intervention to improve bone health in children and the elderly. The aim of this study was to investigate the effect of resistance-aerobic training on RUX2, CTX, RANKL and ALP biomarkers in rats of different ages.
Methods: In the present experimental study, 30 male Wistar rats were obtained from Instituto Pasteur of Iran and were divided into three groups according to their age: immature (2 weeks old), mature (6 weeks old) and elderly (96 weeks old). In each age group, the mice were randomly divided into two training (n=5) and control (n=5) groups. Six weeks of combined training included three sessions of aerobic training and three sessions of resistance training per week. Extracting genes by PCR method was used. One-way analysis of variance and Tukey's post hoc test and SPSS16 software were used. The significance level P≥0.05 was considered.
Results: One-way analysis of variance showed that resistance-aerobic training has had a significant effect on RUNX2, RANKL and ALP variables of rats in different age groups (P < 0.05). This significance was not observed in CTX variable (P > 0.05). On the other hand, the results of Tukey's RUNX2 test were significantly different between the adult training and elderly training groups (p = 0.019) as well as between the elderly control groups (p = 0.01) and adult training (p = 0.002). Regarding the RANKL variable, it showed that there was a significant difference only between the adult exercise group and the elderly control group (p = 0.01).
Conclusion: Resistance-endurance training probably increases absorption and reabsorption biomarkers such as RUX2, RANKL and ALP in immature, mature and elderly male rats.
Methods: In the present experimental study, 30 male Wistar rats were obtained from Instituto Pasteur of Iran and were divided into three groups according to their age: immature (2 weeks old), mature (6 weeks old) and elderly (96 weeks old). In each age group, the mice were randomly divided into two training (n=5) and control (n=5) groups. Six weeks of combined training included three sessions of aerobic training and three sessions of resistance training per week. Extracting genes by PCR method was used. One-way analysis of variance and Tukey's post hoc test and SPSS16 software were used. The significance level P≥0.05 was considered.
Results: One-way analysis of variance showed that resistance-aerobic training has had a significant effect on RUNX2, RANKL and ALP variables of rats in different age groups (P < 0.05). This significance was not observed in CTX variable (P > 0.05). On the other hand, the results of Tukey's RUNX2 test were significantly different between the adult training and elderly training groups (p = 0.019) as well as between the elderly control groups (p = 0.01) and adult training (p = 0.002). Regarding the RANKL variable, it showed that there was a significant difference only between the adult exercise group and the elderly control group (p = 0.01).
Conclusion: Resistance-endurance training probably increases absorption and reabsorption biomarkers such as RUX2, RANKL and ALP in immature, mature and elderly male rats.
Type of Study: Original article |
Subject:
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Received: 2023/12/14 | Accepted: 2024/01/14 | Published: 2024/05/4
Received: 2023/12/14 | Accepted: 2024/01/14 | Published: 2024/05/4
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