Studying Association 48 bp Polymorphism of DRD4 Gene with Attention Deficit Hyperactivity Disorder in Children from North West of Iran

Hosseinpourefeizi , Mohammadali; mehdizadeh fanid, Leila; Noorazar , Gholamreza; Adampourezare , Mina; Golipour Falahi , Mohammadrezare

Volume 25, Issue 5 (Jul-Aug 2017) JSSU 2017, 25(5): 396-403 | Back to browse issues page

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Hosseinpourefeizi M, mehdizadeh fanid L, Noorazar G, Adampourezare M, Golipour Falahi M. Studying Association 48 bp Polymorphism of DRD4 Gene with Attention Deficit Hyperactivity Disorder in Children from North West of Iran . JSSU 2017; 25 (5) :396-403
URL: http://jssu.ssu.ac.ir/article-1-4177-en.html

Studying Association 48 bp Polymorphism of DRD4 Gene with Attention Deficit Hyperactivity Disorder in Children from North West of Iran

Mohammadali Hosseinpourefeizi

, Leila Mehdizadeh fanid ^*

, Gholamreza Noorazar

, Mina Adampourezare

, Mohammadrezare Golipour Falahi

Abstract: (4881 Views)

Introduction: Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder that has defined by hyperactivity, impulsivity and attention deficits. Various neurotransmitters such as dopamine can play a role in its pathophysiology. The aim of this study was to examine the association of two common single nucleotid polymorphisms in DRD₄ gene, a 48 bp VNTR polymorphism, with attention deficit hyperactivity disorder risk among Iranian-Azeri population.
Materials and methods: case–control study was performed on 50 children with attention deficit hyperactivity disorder and 50 healthy ones. Peripheral blood samples were used for Genomic DNA extraction by proteinase K method. The collected data were analyzed through chi-square test (x²), with a significance level of 0.05.
Results: considering the obtained results, there was a significant increase in 4/8 genotype frequency between two groups (p<0.05). Although, there was no significant difference in the allele and genotype frequencies in other genotypes between cases and controls (p>0.05).
Conclusion: Our data confirmed the relationship between polymorphism of DRD4 and ADHD. Further studies with larger population of other groups will be required to explain the relationship between DRD4 polymorphism and the risk of ADHD

Keywords: Key words: ADHD, DRD4 gene, polymorphism, molecular marker

Full-Text [PDF 742 kb] (1369 Downloads)

Type of Study: Original article | Subject: Genetics
Received: 2017/04/24 | Accepted: 2017/07/29 | Published: 2017/10/3

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