Effect of the Aqueous Extract of (Boswelliaserrata )on Volume of Tissue Infract and Neurologic Deficits in Rat Stroke Model

Zolfkhani , Z; Rahnema , M

Volume 24, Issue 5 (Aug 2016) JSSU 2016, 24(5): 409-420 | Back to browse issues page

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Zolfkhani Z, Rahnema M. Effect of the Aqueous Extract of (Boswelliaserrata )on Volume of Tissue Infract and Neurologic Deficits in Rat Stroke Model. JSSU 2016; 24 (5) :409-420
URL: http://jssu.ssu.ac.ir/article-1-3586-en.html

Effect of the Aqueous Extract of (Boswelliaserrata )on Volume of Tissue Infract and Neurologic Deficits in Rat Stroke Model

Z Zolfkhani

, M Rahnema ^*

Abstract: (7531 Views)

Introduction: After cardiovascular disease and cancer, stroke is the third most common cause of death in the most industrialized countries. The aim of study was assessment of relationship between the effect of Boswelliaserrata aqueous extracts infarct volume in rat stroke model.

Methods: Five groups, each consisting of 7 male wistar rats, were studied. The groups consisting of control, sham and three treatment groups received aqueous extracts Boswelliaserrata for 30 days (50,100 and 150mg/kg day, respectively). The control group received distilled water, while in ischemia induction and sham group they did not receive distrill water. Two hours after the last gavaged dose, overly group with 7 pieces operated for measurement of amount of infarct volume and neurologic deficits. (Middle Cerebral Artery Occlusion Model). The data were analyzed via ANOVA test.

Results: In comparison to the ischemia group, pre- treatment aqueous extracts Boswelliaserrata with the doses of 100 and 150 mg/kg body weight indicated a meaningful difference. In addition, median score of neurological violation was significantly reduced through aqueous extracts Boswelliaserrata consumption in the doses of 100 and 150 mg/kg body weight, compared to the ischemia group.

Conclusion:According to this study, aqueous extracts of Boswelliaserrata can reduce the amount of tissue damage caused by stroke and neurological protection.

Keywords: Brain ischemia, Stroke volume, Aqueous extracts Boswellia serrate, Neurologic deficits

Full-Text [PDF 568 kb] (2756 Downloads)

Type of Study: Original article | Subject: Physiology
Received: 2016/01/25 | Accepted: 2016/05/14 | Published: 2016/10/5

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