Strategy of Improvements in the rapeutic index of medicinal herbs of Iranianin digenous: Synthesis and characterization of phospholipid lipid-based vesicles in corporated Trachyspermum copticum

Haghiralsadat , F; Azhdari , M; Kalantar , SM; Naderinezhad , S; Teymourizadeh , K; Yazdani , M; Hashemi , M; Daneshmand , F

Volume 24, Issue 6 (sep 2016) JSSU 2016, 24(6): 468-478 | Back to browse issues page

Mendeley

Zotero

RefWorks

Haghiralsadat F, Azhdari M, Kalantar S, Naderinezhad S, Teymourizadeh K, Yazdani M, et al . Strategy of Improvements in the rapeutic index of medicinal herbs of Iranianin digenous: Synthesis and characterization of phospholipid lipid-based vesicles in corporated Trachyspermum copticum. JSSU 2016; 24 (6) :468-478
URL: http://jssu.ssu.ac.ir/article-1-3395-en.html

Strategy of Improvements in the rapeutic index of medicinal herbs of Iranianin digenous: Synthesis and characterization of phospholipid lipid-based vesicles in corporated Trachyspermum copticum

F Haghiralsadat ^*

, M Azhdari

, SM Kalantar

, S Naderinezhad

, K Teymourizadeh

, M Yazdani

, M Hashemi

, F Daneshmand

Abstract: (8196 Views)

Introduction: Medicinal herbs are one of the most valuable Iranian National assets. Herbal essential oils have valuable therapeutic properties. Oxidation and volatile of essential oils caused some limitations in its usage. Nanoliposomes are nonometric lipid-based vesicles. Drug delivery carrier to improve delivery of therapeutic agent is one of the most well-known application of liposomal vesicles. In recent years, scientists paid much attention to encapsulate plant essential oil in nanocarriers. The goal of presented study was encapsulation of Trachyspermumcopticum in nanoliposomal carriers to improve the therapeutic functionality.

Methods: The essential oil of Trachyspermumcopticum was extracted by Clevenger instrument using hydrodistilation method and its components were determined with gas-mass chromatography. Small unilamellar lipid based vesicles containing Trachyspermumcopticum essential oil were prepared using thin film hydration method. Lipid phase were contained SPC 80, cholesterol and Trachyspermumcopticum essential oil. Nano-vesicles were evaluated by several analyses such as encapsulation efficiency, size, zeta potential, release kinetic profile and surface morphology.

Results: Results showed that the encapsulation efficiency of entrapped essential oil was 35.6±7.4% and mean nano-liposome diameter was 186.1 nm. The prepared nano-vesicle led to controlled release profile.

Conclusion: In the present study, encapsulation of Trachyspermumcopticum essential oil into nano liposome was performed in order increasing stability, water- solubility and improving therapeutic index. The prepared formulation was slow-release, well-coating to preserve the essential oil against oxidation and increasing stability.

Keywords: Phospholipid Based Vesicle, Trachyspermum Copticum Essential Oil, Encapsulation, Essential Oil Extraction, AndThymol

Full-Text [PDF 846 kb] (2502 Downloads)

Type of Study: Original article | Subject: Pharmacology
Received: 2015/09/7 | Accepted: 2016/06/5 | Published: 2016/10/4

References

1. 1- Pour-seyedi S. Assessment of germination and cytology of three Iranian caraway genus: Bunium, Carum and Cuminum. University of Tehran: Tehran, 1994: 89.

2. 2- Ghassemi H, Harrison G, Mohammad K. An accelerated nutrition transition in Iran. Pub Health Nutri 2002; 5(1a): 149-55.

3. 3- HI JM, Flora Iranica, 1987.

4. 4- G Amin. Iranian traditional medicinal plants. Research Deputy of Health Ministry, Tehran; 1991: p.130.

5. 5- MS. Evaluation and comparison of Macroscopic, microscopic and phytochemical properties of anise, Foeniculum vulgare and Trachyspermum Copticum fruits. Isfahan University of Medical Science, 1992.

6. 6- C Engineer, J Parikh, A Raval. Review on hydrolytic degradation behavior of biodegradable polymers from controlled drug delivery system. Trends Biomater Artif Organs 2011; 25: 79-85.

7. 7- KMK Selim, JH Lee, SJ Kim, Z Xing, IK Kang ,Y Chang, et al. Surface modification of magnetites using maltotrionic acid and folic acid for molecular imaging. Macromol Res 2006;14(6): 646-53.

8. 8- SR Mittal, A Mathur, R Gokhroo, GGP Santosh Kaushik. Letter to the editor: Effects of the ayurvedic drug cholesteronil on cardiovascular risk factors, Cardiovasc. Drugs Ther 2000; 14(1): 95-6.

9. 9- HF. The chemical assessment of seed essence and the Comparison of antioxidant effect among three native medicinal plants of the Yazd province (Bunium persicum Boiss, Cuminum cyminum L, Trachyspermum copticum L). Shahid Beheshti University; 2010.

10. 10- F Haghirossadat, F Bernard, M Kalantar, MH Sheikhha, F Hokmollahi, M Azimzadeh, et al. Bunium persicum (Black Caraway) of Yazd province: chemical assessment and Evaluation of its antioxidant effects. SSU J 2010; 18(3): 284-91.

11. 11- K Begum, A Sarker, IJ Shimu, MMI Chowdhury, R ul Jalil. Characterization of Nanoemulsion Prepared from Self-emulsifying Rifampicin and its Antibacterial Effect on Staphylococcus aureus and Stap. epidermidis Isolated from Acne: Dhaka Uni J Pharm Sci 2016; 14(2): 171-7.

12. 12- F Haghiralsadat, G Amoabediny, MH Sheikhha, B Zandieh-doulabi, S Naderinezhad, M Helder. New liposomal doxorubicin nanoformulation for osteosarcoma? Drug release kinetic study based on thermo and pH sensitivity, RSC Adv. (n.d.).

13. 13- S Nagulakshmi, NB Shankaracharya, JP Naik, LJM Rao. Studies on chemical and technological aspects of ajowan aspects (Trachyspermum ammi). J Food Sci Techol Mysore. 39 (2000) 277–281.

14. 14- K.V.M. lagevio M.B, Trachyspermum ammian essential crop for north persian. J Med Aromat Plant Sci 1999; 4: 996.

15. 15- T.L. Steveson F, Jonn sron M, Peckie J. Cattle manure as a Corps in zero and conventional tillage systems. Can J Plant Sci 1998; 48(6): 1267-72.

16. 16- T SAZ Akbarinia A, SF, Ghalavand A. Chemical composition of seed essence of Trachyspermum copticum produced in Qazvin Province. Sci J Med Univ Qazvin 2005; 36: 22-6.

17. 17- N Chorianopoulos, E Kalpoutzakis, N Aligiannis, S Mitaku, GJ Nychas, SA Haroutounian. Essential oils of Satureja, Origanum, and Thymus species: chemical composition and antibacterial activities against foodborne pathogens. J. Agric Food Chem 2004; 52: 8261-7.

18. 18- E Pinto, C Pina Vaz, L Salgueiro, MJ, Gonçalves S. Costa-de-Oliveira, C Cavaleiro, et al. Antifungal activity of the essential oil of Thymus pulegioides on Candida, Aspergillus and dermatophyte species. J Med Microbiol 2006; 55(10): 1367-73.

19. 19- F Sharififar, MH Moshafi, SH Mansouri, M Khodashenas, M Khoshnoodi. In vitro evaluation of antibacterial and antioxidant activities of the essential oil and methanol extract of endemic Zataria multiflora Boiss. Food Control 2007; 18(7): 800-5.

20. 20- M Srivastava, P Baby, A Saxena. GC-MS investigation and antimicrobial activity of the essential oil of Carum copticum Benth & Hook. Acta Aliment 1999; 28(3): 291-5.

21. 21- SF Hosseini, M Zandi, M Rezaei, F Farahmandghavi. Two-step method for encapsulation of oregano essential oil in chitosan nanoparticles: preparation, characterization and in vitro release study. Carbohydr Polym 2013; 95(1): 50-6.

22. 22- C Celia, E Trapasso, M Locatelli, M Navarra, CA Ventura, J Wolfram, et al. Anticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cells, Colloids Surfaces B Biointerfaces. 2013; 112: 548-53.

23. 23- F Tao, LE Hill, Y Peng, CL Gomes. Synthesis and characterization of β-cyclodextrin inclusion complexes of thymol and thyme oil for antimicrobial delivery applications. LWT-Food Sci Technol 2014; 59(1): 247-55.

24. 24- KT Trifković, NZ Milašinović, .B Djordjević, MTK Krušić, ZD Knežević-Jugović, VA Nedović, et al. Chitosan microbeads for encapsulation of thyme (Thymus serpyllum L.) polyphenols, Carbohydr. Polym 2014; 111: 901-7.