Study of the Role of Garlic Consumption in Helicobacter Pylori Eradication

Ghobeh, M; Shaker Hosseini, R; Navai, L; Mir Sattari, D; Rashid Khani, B; Fahmideh Norouzi, M

Volume 18, Issue 4 (Sep-Oct 2010) JSSU 2010, 18(4): 337-347 | Back to browse issues page

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Ghobeh M, Shaker Hosseini R, Navai L, Mir Sattari D, Rashid Khani B, Fahmideh Norouzi M. Study of the Role of Garlic Consumption in Helicobacter Pylori Eradication. JSSU 2010; 18 (4) :337-347
URL: http://jssu.ssu.ac.ir/article-1-1144-en.html

Study of the Role of Garlic Consumption in Helicobacter Pylori Eradication

M Ghobeh

, L Navai ^*

Abstract: (83114 Views)

Introduction: There are various ways to treat H.pylori infection, such as triple-therapy and quadruple therapy for two weeks. However, these treatments have some side effects and Helicobacter pylori easily become resistant to these antibiotics. Some studies have confirmed a relationship between consumption of garlic and reduction in Helicobacter pylori infection, whereas some others have rejected this relationship. Therefore, this present study was performed to determine the effects of garlic on Helicobacter pylori infection. Methods: This trial was performed in a randomized, case-controlled design on outpatients diagnosed with Helicobacter pylori infection. The patients in the case group took four grams of garlic powder daily (two tablets each containing two grams of garlic powder) whereas the patients in the control group took two placebo tablets (each containing two grams of white flour). In order to confirm the presence of Helicobacter pylori infection, urea breath test was taken, and in order to examine the presence of inflammation and/or ulcer in stomach, esophagus and duodenum, upper endoscopy was performed at the beginning and the end of the study. Results: At the beginning of this study, all the patients had positive urea breath test. At the end of this study, the results of urea breat*- test showed that Helicobacter pylori infection was negative in 87% of the case group and 73% of control group showing eradication of Helicobacter pylori infection. However, this difference was not significant statistically when compared to the control group (P= 0.36). Conclusion: These findings suggest that taking garlic powder along with prescribed antibiotics can help in reducing Helicobacter pylori infection.

Keywords: Helicobacter Pylori; Garlic; Anti- Bacterial Agents

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Type of Study: Original article | Subject: General
Received: 2010/09/8 | Published: 2010/09/15