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Showing 14 results for Fatemi

K Ghazisaidi, Sh Vatani , F Fateminasab, N Dehghanzadeh, M Mohamadi,
Volume 15, Issue 2 (Summer 2007)
Abstract

Introduction: Ureaplasma uriealyticum is one of the most important causes of Nongonococcal and Nonspecific urethritis (NGU & NSU) in men. Mycoplasma hominis too has a causal role in NGU & NSU. This study aimed to investigate whether it is possible to detect Mycoplasma hominis and Ureaplasma uriealyticum in first voided urine samples in men suffering from NGU & NSU without complaints of urethral secretions and in women with clinical symptoms despite negative vaginal secretion culture test results. Methods: First voided urine samples were taken from 150 patients (21 women & 129 men) suffering from NGU & NSU who referred to the Division of Bacteriology, School of Public Health, Tehran University of Medical Sciences in 2004-2005. Samples were examined by culture method. Results: Cultures were positive for Mycoplasma and Ureoplasma in 49 (32.6 %) of the 150 samples. Of the 21 samples taken from women, 5 samples were positive for Mycoplasma & Ureoplasma (2 samples Mycoplasma, 3 samples Ureaplasma). Samples from 44 men were positive for Ureoplasma & Mycoplasma(17 samples Mycoplasma, 4 samples Ureaplasma and 23 samples were positive for both). Ureoplasma urealyticum was detected in 30 samples (20%) and Mycoplasma hominis, was detected in 42 samples (28%). Conclusion: The results of this study provides evidence that culture tests can be done using voided urine in order to detect Mycoplasma hominis and ureaplasma urealyticum in patients suffering from Nongonococcal urethris men who do not have urethral secretions and women with clinical symptoms despite negative vaginal secretion culture test results.
M Golestan, Ah Fatemi, A Bahrami-Ahmadi,
Volume 15, Issue 4 (Winter 2008)
Abstract

Introduction: Hyperbilirubinemia is a common benign problem in neonates. Nonetheless, if untreated, severe hyperbilirubinemia is potentially neurotoxic. The standard method for diagnosis of hyperbilirubinemia is determination of serum bilirubin levels in the laboratory that requires a blood sample which is both painful and stressful for neonates and entails cost and time. The objective of this study was to study the correlation between transcutaneous bilirubin levels (JH 20-1 bilirobinometer) and serum bilirubin levels. Method: This prospective study was done on 100 jaundiced newborn term infants from March to October, 2006. Initial clinical assessment of jaundice was carried out by a physician (researcher) and simultaneously, blood sample was collected and a JH20-1 bilirubinometer was applied at two sites forehead and sternum. Results: The study group consisted of 57 boys and 43 girls diagnosed as jaundiced neonates. The mean serum bilirubin and mean transcutaneous bilirubin levels at forehead and sternum were 13.35, 12.95 and 12.46 mg/dl, respectively. The correlation coefficient of bilirubin levels estimated by the bilirubinometer at the forehead and sternum and serum levels were 0.773 and 0.731, respectively. At bilirubin levels higher than 12 mg/dl (cut off point), the bilirubinometer had a decreased sensitivity, but an increased specificity. Conclusion: Transcutaneous bilirubin measurements using JH20-1 bilirubinimeter correlate well with total serum bilirubin levels, but when bilirubin levels are higher than 12mg/dl, sensitivity of the device is reduced and therefore not reliable.
M Fatemi, A Noori,
Volume 23, Issue 5 (Jul-Aug 2015)
Abstract

Background: Silver nanoparticles lie within the most commercialized nanoparticles due to their strong antimicrobial properties. Animal studies have recently indicated that silver nanoparticles can be transfered from mothers to their pups via the maternal milk. However, there seems to be scant information in regard with the toxicity of these nanoparticles on various organs within sensitive developmental stages. Hence, this study aimed to investigate the effect of silver nanoparticles on the developing liver of rat pups after maternal exposure(during lactation) to these nanoparticles. Methods: The lactating mothers(30 rats) were divided into two groups. The treatment and control groups orally recieved nano particles(25 mg/kg BW) and deionized water(from 1st to 12th days of lactation), respectively. The pups were killed and their livers were collected, some of which were sliced and stained with Hematoxylin and Eosin. The concentration of Malondialdehyde, Glutathione, Glutathione peroxidase activity and silver level of the pups' livers were determined utilizing spectrophotometric assay and inductively coupled plasma mass spectrometry analysis, respectively. Results: The study results demonstrated a significant increase in malondialdehyde and silver levels(p<0.001)as well as a significant decrease in Glutathione peroxidase activity(p<0.01) and Glutathione concentration(p<0.05) of the pups' livers in the treatment group compared with those of the control group. Moreover, histopathological examination indicated sinusoidal dilatation and congestion as well as fatty degeneration in the pups' livers of the treated group. Conclusion: The study findings proposed that exposure to silver nanoparticles during lactation may induce toxicity in the liver of the pups, though further experiments are required in this field.
M Porsesh, Ah Habibi, S Ahmadi Barati , Sr Fatemi,
Volume 24, Issue 9 (Dec 2016)
Abstract

Introduction: Extreme sports are associated with immunological changes as well as changes in the indices of inflammation and muscle damage. So, the purpose of this study was to compare the effect of 6 weeks resistance training with and without vascular occlusion, on serum levels of CRP and LDH in active girls.

Methods: This study was a quasi-experimental one. 36 female  students of  physical education with an average aged 20.51 ±1.39 years and BMI 23.32 ± 2.79 kg/m2 were divided into three groups: resistance training without occlusion (exercise at 75% of one repetition maximum), resistance training with vascular occlusion (exercise at 30% of one repetition maximum with closing of tourniquet around the proximal arm) and the control group. Both training exercise groups performed a six-week training program consisting three sessions per week. During this period, the control group performed their daily activities. Blood samples were taken before the start of training and 24 hours after the last training session. Spectrophotometric and  ELISA method was used for evaluating lactate dehydrogenise and CRP. Data were analyzed using paired sample t test,  and one-way ANOVA. To compromise the results between three groups bonferroni test was used.

Results: After 6 weeks of resistance training with and without vascular occlusion, index of muscle damage (LDH) revealed a significant increase in response to resistance training (p<.05). and simultaneously (CRP) index showed no significant difference between the three groups (p>.05).

Conclusion: According to the results of the research, both types of resistance training have a positive effect on variables of  inflammatory marker of muscle damage. But it seems that in vascular- occlusion group changes are more obvious.


F Delrobaei, M Bahmani, F Ayoobi, A Shamsizadeh, I Fatemi, M Allahtavakoli,
Volume 25, Issue 3 (Jun 2017)
Abstract

Introduction: Estrogen regulates many processes in the brain such as synaptic formation, learning, and memory. Empirical evidence shows that there is a correlation among menopause, memory impairment, and anxiety due to Estrogen deficiency. In this study, we tested the effect of Metformin (Met) with antioxidant effect, which can improve the impairment of tactile learning and anxiety-like behavior in ovarectomized mice.
Methods: Thirty-two female mice weighting 20±5 g were randomly divided into four groups of eight, including sham group, ovariectomy, ovariectomy with doses 7 and 15 mg/kg of Met. At first, mice were ovariectomized and then they were treated with the doses of the Met or water for 21 days. Then, tactile learning (by Novel Object Recognition Test) and anxiety like-behavior (by Elevated Plus-maze) were determined.
Results: Met at the doses of 7 or 15 mg/kg significantly improved tactile learning compared to the ovariectomy group. Met at the doses of 7 or 15 mg/kg significantly increased Open Arm Time (%OAT) and Open Arm Entries (%OAE) compared to the ovariectomy group.
Conclusion: Met especially at the dose of 7 mg/kg showed a significant role in improving the anxiety and tactile learning in the ovariectomized mice.
Seyedeh Fatemeh Fatemi, Zia Fallah Mohammadi, Vahid Talebi, Sayed Mojtaba Hosseini,
Volume 26, Issue 8 (Nov 2019)
Abstract

Introdution: The aim of this study was to investigate the effect of vitamin D supplementation on Klotho levels of the brain tissue.
Methods: In this laboratory experimental study, 25 female Lewis rats, after 2 weeks adaptation to lab environmental, were randomly divided into 5 groups: 1-control; 2- control+ EAE; 3-sham; 4vitamin D; 5-vitaminD + EAE.
Results: The data were analyzed  using one way ANOVA, and to examine the weight changes Mann-Whitney test was used to the research groups. In order to induce EAE, 0.4 ml of solution, a combination of guinea Hindi pig spinal cord and adjuvant ratio was injected to each animal. Klotho levels were measured by ELISA.
Finding: There was significantly different in Klotho levels of brain tissue of control+ EAE compared to control group (P=0/001). There was significant difference in Klotho levels of the brain tissue in EAE +vitamin D group compared to control group (P=0/001). In addition, the weight of vitamin D+EAE group was more than control+EAE group (P=0/006).
Conclusion: Pre-treatment with vitamin D  supplementation increases the Klotho levels of brain tissue and may have protective role against EAE.
Maryam Zakeri, Iman Fatemi, Mohammad Ali Zakeri, Mohammad Alahtavakoli,
Volume 26, Issue 10 (Jan 2019)
Abstract

Introduction: Aging process is inevitable, which increases the risk of illness and death in people. Menopause occurs as a part of the aging process. The aim of this study was to evaluate the effect of metformin (Met) on muscle strength, anxiety and memory in ovariectomized mice
Methods: Thiswas an experimental study.  96 female mice (Age 6 months) (20-25 g) were randomly divided into sex groups, including: (1) sham, (2) ovariectomized, (3 and 4) ovariectomized + Met (1 and 10 mg/kg) (5) Met 10 mg/kg, and (6) healthy. At first, the mice were ovariectomized and then received Met for six months. Muscle strength, memory, and anxiety in the exprimental groups was examined. Statistical analysis was performed via SPSS16 and the differences between groups were analyzed by one way ANOVA.
Results: The results of the study showed Met with doses of 1 mg / kg and 10 mg significantly reduced the  anxiety of mice (p = 0.0295 and p = 0.0024, respectively), increased memory (p = 0.0004 and p = 0.0044, respectively) and at dose of 10 mg / kg it improved muscle strength (p = 0.0148) compared to the ovariectomy group.
Conclusion: Metformin  has beneficial effects on behavioural manifestations of aging and ovarectomy

Mohammad Pak-Hashemi, Mahsa Hassanipour, Ayat Kaeidi, Pooya Saeed-Askari, Iman Fatemi, Mohammad Reza Rahmani, Elham Hakimizadeh, Jalal Hassanshahi, Vahid Ehsani, Zahra Taghipour, Marzieh Khademi, Mohammad Allahtavakoli,
Volume 28, Issue 3 (6-2020)
Abstract

Introduction: Aging is a complex process and is considered as a risk factor for many diseases such as hypertension, Alzheimer, cancer, depression and anxiety. Recently, it has been shown that metformin, an anti-diabetic drug, has important neurological effects such as preventing memory loss, stroke, anxiety, inflammation and seizures. Therefore, the aim of this study was investigating the effects of metformin on some cognitive factors in elderly male rats.
Methods: 24 rats (22 months) were randomly divided into 3 groups (n=8). The first group was the control group that received water orally, the second group received metformin 1 mg/kg orally and the third group received metformin 10 mg/kg orally. After treatment for 40 days (once daily), behavioral tests, including Y-maze, elevated plus maze and depression test were performed on animals. Results were analyzed using GraphPad Prism version 6 and One-way ANOVA followed by Tukey-post hoc test.
Results: The results of this study showed that metformin at a dose of 10 mg/kg significantly reduced anxiety (P<0.001) and depression (P<0.001) in older animals. Metformin at a dose of 1 mg/kg failed to improve aging-related disorders in this model.
Conclusion: Metformin at a dose of 10 mg/kg can reduce the quality of life by reducing anxiety and depression.
Mahsa Porsesh , Abdolhamid Habibi, Saeed Ahmadi Barati , Seyed Reza Fatemi ,
Volume 28, Issue 11 (1-2021)
Abstract

 
Corrigendum notice: Comparing the effect of 6 weeks of resistance training with and without vascular occlusion, on
C-reactive protein and lactate dehydrogenase levels in active girls
 
 
           Mahsa Porsesh *1, Abdolhamid Habibi2, Saeed Ahmadi Barati3, Seyed Reza Fatemi4             
 
1-3Department of Sport Physiology, Faculty of Physical Education and Sports Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
4Department of Veterinary Medical, Shahid Chamran University of Ahvaz, Ahvaz, Iran.


Corrigendum notice: In the above article, which was published in the Volume 24, Issue of 9, December 2016, affiliations of all of the authors have been corrected
Sajjad Sattai Mokhtari, Elham Hakimizadeh, Mojdeh Haj Mohammadi, Ayat Kaeidi, Iman Fatemi, Mahsa Hassanipour, Jalal Hassanshahi, Mohammad Allahtavakoli,
Volume 28, Issue 11 (1-2021)
Abstract

Introduction: During menopause, which is a part of the aging process in women, the level of sex hormones decreases, which causes problems such as memory impairment and cognitive functions. One of the treatment options for these disorders is hormone therapy, which has several side effects. The present study investigated the effect of remote ischemic conditioning (RIC) technique on memory improvement, muscle strength, motor and balance function in ovariectomized rats.
Methods: In the present experimental study, 24 Wistar female rats with an approximate weight of (170-220 g) were divided into three groups (n = 8) including, 1: control group, 2: ovariectomy group and 3: ovariectomy+ treatment group. Initially, the animals in the second and third groups underwent ovariectomy surgery. The RIC techniques were performed on treatment group of rats for two months. After that, memory, muscle strength, and motor and balance function were assessed in all groups. SPSS software (V21) and one-way analysis of variance were used for statistical analysis.
Results: The result of this study showed that RIC technique significantly improved memory in the ovariectomy+treatment group in comparison with the ovariectomy group (P<0.04). The results of forced swim test showed that RIC technique significant increase muscle strength in the ovariectomy+treatment group compared to the ovariectomy group (P<0.0281).The result of motor and balance performance did not show any significant improvement.
Conclusion: RIC technique can have beneficial effects on menopausal-related disorders and ovariectomy.

Zahra Eshaghi, Abdolhamid Habibi, Seyed Reza Fatemi Tabatabaei, Gholamreza Goudarzi,
Volume 28, Issue 12 (2-2021)
Abstract

Introduction: Scientific evidence suggests the role of environmental pollutants, especially particulate mater in oxidative stress. However, the regular aerobic training has an important role in enhancing antioxidant defense and resistance to oxidative stress. Therefore, the purpose of this study was to investigate the effect of 6 weeks of aerobic training on the oxidative stress condition of male Wistar rats exposed to particulate matter.
Methods: In this experimental study, 32 male rats (245 ± 8.5 g) aged 10 weeks, were divided into 4 groups of 8 rats each. The rats received the infusion of the particulate matter for 6 weeks through the nose. The exercise program included 6 weeks of aerobic training with 50% of maximum exercise; at the end of 6 weeks of the program, 24 hours after the last exercise session, blood samples were taken. Descriptive one-way analysis of variance (ANOVA) was used in different groups. If analysis were significant, differences between groups were estimated using LSD test. Significance was defined as P≤0.05. Statistical analysis was performed using SPSS software version 16.
Results: After 6 weeks of aerobic training, levels of Malondialdehyde in both groups: healthy exercise and particulate matter+exercise decreased significantly and in the infected group (P≤0.05), but did not show significant difference compared to the control group (P≥0.05). The level of Superoxide dismutase in the infected group showed a significant increase. There was no significant difference between the two Glutathione peroxidas and catalase enzymes in each group (P≥0.05).
Conclusion: Based on the results, it can be concluded that aerobic training may be effective in reducing lipid peroxidation and enhancing antioxidant defense.

Seyedeh Fatemeh Fatemi, Seyed Abdollah Hashemvarzi, Amin Farzaneh Hesari,
Volume 29, Issue 8 (11-2021)
Abstract

Introduction: Diabetes is a common metabolic disease, which leads to diabetic peripheral neuropathy. Peripheral neuron damage result in Nav1.3 elevations. Exercise training has beneficial role in diabetes management and peripheral neuropathy. Alpha lipoic acid (ALA) is a powerful biological antioxidant. However, the role of exercise training and ALA on Nav1.3 are not well understood. The aim of the present study was to investigate the effect of training with different intensity and Alpha lipoic acid supplement on soleus muscle Nav1.3 protein in rats with type 2 diabetes. Thirty-five male Wistar rats were randomly divided into seven groups: healthy control, diabetic, complementary diabetic, intensive exercise diabetic, moderate exercise diabetic, intensive exercise + supplemental diabetic, moderate exercise + complementary diabetic.
Methods: In this experimental study, 35 male Wistar rats were randomly divided into seven groups: healthy control, diabetic (D), complementary (alpha lipoic acid) diabetic (ALA), diabetic high intensity training (HIT), diabetic moderate intensity training (MIT), diabetes HIT+ALA (ALA + HIT), diabetic MIT + ALA (ALA + MIT). Rats were diabetic by intra-peritoneal injection of STZ. The HIT and MIT protocols were performed five days a week for six weeks. HIIT included 10 bouts of four minutes (running at 85–90% of maximum speed) and MIT 13 bouts of four minutes (running at 65–70% of maximum speed). ALA was administered orally 20 mg/kg once a day by gavage. Nav1.3 protein levels were measured by immunohistochemistry method. Statistical operations were performed with SPSS version 16 software. One-way analysis of variance and Tukey were used to analyze the data.
Results: The level of Nav1.3 increased significantly in diabetic group compared to the control (p≤0.0001). Moreover, HIT (p=0.0015), MIT p=0.0056), ALA+HIT (p≤0.0001) and ALA+MIT (p≤0.0001) decreased significantly Nav1.3 compared to the diabetic group.
Conclusion: HIT and MIT can reduce the expression of NaV1.3 in soleus muscle in diabetic rats. ALA combined with exercise training can be more effective to reduce diabetic neuropathy.

Seyedeh Fatemeh Fatemi, Seyed Abdollah Hashemvarzi, Amin Farzaneh Hesari,
Volume 29, Issue 9 (12-2021)
Abstract

Corrigendum notice: Protective Effect of Interval Exercise Training with Different Intensity and Alpha-Lipoic Acid Supplement on Nav1.3 Protein in Soleus Muscle of Diabetic Rats
 
Seyedeh Fatemeh Fatemi1, Seyed Abdollah Hashemvarzi1, Amin Farzaneh Hesari1
 
1Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran.
*Corresponding author: Tel: 09111160278, email: hashemvarzi_tkd@yahoo.com

Corrigendum notice: In the above article, which was published in the Volume 29, Issue of 8, November 2021, affiliations of all of the authors have been corrected.
Seyed Abdollah Fatemi, Amin Frzaneh Hesari, Minoo Dadban Shahamat,
Volume 30, Issue 2 (5-2022)
Abstract

Introduction: Activation of NLRP-3 Inflammasome is considered an indicator of chronic inflammation in type 2 diabetes. Regular exercise training along with antioxidants supplements can control inflammation. The aim of the present study was to investigate the effect of training with different intensity and alpha lipoic acid supplement on pancreatic NLRP-3 expression in diabetic rats.
Methods: In this experimental study, 35 Wistar rats were randomly divided into seven groups: control, diabetic, diabetic+ supplement (S), diabetic+ high intensity training (HIT), diabetic+ moderate intensity training (MIT), diabetic+ high intensity training + supplementation (HIT+S), diabetic+ moderate intensity training + supplementation (MIT+S). The HIT and MIT protocols were performed five days a week for six weeks. HIIT included 10 bouts of four minutes running (at 85–90% of VO2max) and MIT, 13 bouts of four minutes running (at 65–70% of VO2max). Alpha lipoic acid was administered orally at a dose of 20 mg/kg was given to rats once a day by gavage. Blood and tissue sample was taken 24 h after last exercise session. Real-time PCR method for the relative expression of NLRP-3 gene expression was used. Results: Expression of LRP-3 gene in pancreatic tissue was increased significantly in the diabetic group compared to control group (p=0.0001). In addition, S (P = 0.021), MIT (P = 0.009), HIT (P = 0.001), MIT+S (P = 0.003) and HIT+S (P = 0.0001), significantly reduced the NLRP-3 levels in pancreatic tissue compared to the diabetic group.
Conclusion: Type 2 diabetes is associated with increased mRNA NLRP-3 in pancreatic tissue. MIT and HIT plus alpha lipoic acid can be considered as an effective intervention in decreasing pancreatic mRNA NLRP-3 in diabetic rats.


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