Volume 33, Issue 12 (3-2026)
JSSU 2026, 33(12): 9671-9383 |
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Mesripour A, Satari S, Meamar R, Akbari V, karimi R. Evaluating the Impact of Vitamins C and E Treatment on Paraquat-Induced Acute Toxicity in Animal: A Systematic Review and Meta-Analysis. JSSU 2026; 33 (12) :9671-9383
URL: http://jssu.ssu.ac.ir/article-1-6470-en.html
URL: http://jssu.ssu.ac.ir/article-1-6470-en.html
Abstract: (14 Views)
Introduction: Paraquat is a widely used but extremely toxic herbicide that can cause severe health complications or even death if ingested or absorbed. Managing paraquat poisoning remains a great challenge since, despite the availability of treatment such as gastric lavage and antioxidantherapy, the mortality rate remains high. This meta-analysis study aimed to investigate the effect of vitamin C and E treatment on paraquat poisoning in animal studies.t
Methods: A comprehensive systematic search was conducted among electronic databases, including the Cochrane Library, PubMed, Scopus, ISI web of science, and Google Scholar, to identify relevant studies published from inception to December 2024 for animal studies. The meta-analysis was performed using a random-effects model based on data extracted from these animal studies.
Results: Finally, nine animal studies were included in the meta-analysis. The most frequently examined parameters included blood factors, liver enzyme levels, and creatinine levels, which therefore became the focus of the analysis. The meta-analysis showed a significant relationship between vitamin E administration, creatinine parameters (P < 0.001) and ALP levels (P = 0.026) after paraquat poisoning.
Conclusion: Although some parameters changed due to the small number of samples, a meta-analysis of all parameters was impossible. Creatinine and the ALP enzyme significantly changed in rat receiving vitamins. However, the two indices, SGPT and SGOT, did not change significantly. Further research with a larger number of samples is needed to draw a definitive conclusion.
Methods: A comprehensive systematic search was conducted among electronic databases, including the Cochrane Library, PubMed, Scopus, ISI web of science, and Google Scholar, to identify relevant studies published from inception to December 2024 for animal studies. The meta-analysis was performed using a random-effects model based on data extracted from these animal studies.
Results: Finally, nine animal studies were included in the meta-analysis. The most frequently examined parameters included blood factors, liver enzyme levels, and creatinine levels, which therefore became the focus of the analysis. The meta-analysis showed a significant relationship between vitamin E administration, creatinine parameters (P < 0.001) and ALP levels (P = 0.026) after paraquat poisoning.
Conclusion: Although some parameters changed due to the small number of samples, a meta-analysis of all parameters was impossible. Creatinine and the ALP enzyme significantly changed in rat receiving vitamins. However, the two indices, SGPT and SGOT, did not change significantly. Further research with a larger number of samples is needed to draw a definitive conclusion.
Type of Study: Review article |
Subject:
other
Received: 2025/07/1 | Accepted: 2025/08/11 | Published: 2026/05/5
Received: 2025/07/1 | Accepted: 2025/08/11 | Published: 2026/05/5
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