Volume 25, Issue 4 (July 2017)
JSSU 2017, 25(4): 311-321 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
kaboli H, Haghighat S.
Evaluation of Borrago topical effects on wound healing of cutting wounds in mice
. JSSU 2017; 25 (4) :311-321
URL: http://jssu.ssu.ac.ir/article-1-2861-en.html
URL: http://jssu.ssu.ac.ir/article-1-2861-en.html
Abstract: (5885 Views)
Introduction: Borrago Officinalis has wide effects on rheumatoid arthritis, cardiovascular disorder, gastrointestinal diseases, pulmonary disorders and skin allergies. This plant can be useful in wound healing process due to specific compounds. The aim of this study was comparative evaluation of the effects of Borrago Officinalis with iodine and phenytoin on wound healing.
Methods: This is an experimental research study performed on 20 mature mice, in four therapeutic groups, including the Borrago Officinalis extract, iodine, phenytoin and control groups. Cutting wounds in dorsal part of mice body were evaluated through healing rate and histopathology at days 3, 7, 10 and 14. Data were analyzed using SPSS software using ANOVA and TUKEY tests.
Results: The findings about the mean area and the increase in the rate of wound healing in the use of Borrago Officinalis were compared at the 3rd, 7th, 10th and 14th days; the results indicated that the Borrago Officinalis had a positive effect on healing wounds (P˂ 0.05). However, this effect is more rather than both the iodine and control groups, but is less than the phenytoin group. . From the viewpoint of histopathology, the findings indicated a significant decrease in terms of inflammatory factors in Borrago Officinalis group (P= 0.007). The phenytoin group in relative to granulation tissue and epithelial cell growth had a higher level than the other of the groups.
Conclusion: The results show the positive effect of Borrago Officinalis extract on wound healing. In comparison, this effect is less than the phenytoin and more than iodine. More studies are needed on different doses of this plant and its comparative effect with other common treatments for wound healing.
Methods: This is an experimental research study performed on 20 mature mice, in four therapeutic groups, including the Borrago Officinalis extract, iodine, phenytoin and control groups. Cutting wounds in dorsal part of mice body were evaluated through healing rate and histopathology at days 3, 7, 10 and 14. Data were analyzed using SPSS software using ANOVA and TUKEY tests.
Results: The findings about the mean area and the increase in the rate of wound healing in the use of Borrago Officinalis were compared at the 3rd, 7th, 10th and 14th days; the results indicated that the Borrago Officinalis had a positive effect on healing wounds (P˂ 0.05). However, this effect is more rather than both the iodine and control groups, but is less than the phenytoin group. . From the viewpoint of histopathology, the findings indicated a significant decrease in terms of inflammatory factors in Borrago Officinalis group (P= 0.007). The phenytoin group in relative to granulation tissue and epithelial cell growth had a higher level than the other of the groups.
Conclusion: The results show the positive effect of Borrago Officinalis extract on wound healing. In comparison, this effect is less than the phenytoin and more than iodine. More studies are needed on different doses of this plant and its comparative effect with other common treatments for wound healing.
Type of Study: Original article |
Subject:
Pharmacology
Received: 2014/07/11 | Accepted: 2017/09/24 | Published: 2017/09/25
Received: 2014/07/11 | Accepted: 2017/09/24 | Published: 2017/09/25
References
1. Potter PA, Perry AG, Stockert P, Hall A. Fundamentals of nursing. Elsevier Health Sciences; 2016.
2. Hemmati AA, Rashidi I, Jafari M. PROMOTION OF WOUND HEALING BY HYPERICUM PERFORATUM EXTRACT IN RABBIT. JJNPP 2007; 2(2): 78-86
3. Harbige LS, Layward L, Morris-Downes MM. The protective effects of omega-6 fatty acids in experimental autoimmune encephalomyelitis (EAE) in relation to transforming growth factor-beta 1 (TGF-β1) up-regulation and increased prostaglandin E2 (PG E2) production. Clinical. Experience. Immunology. 2000, 122: 445-452.
4. Edefia A, Tete-Benissan A, Awaga K and Akpagana K. Review of twelve West Africa medical plant: Active phytochemical combinations in direct biochemically wound healing process. Journal of Medicinal Plants Research. 2015. 9(34): 908-915.
5. Evans, Richard P. "Surgical site infection prevention and control: an emerging paradigm." The Journal of Bone & Joint Surgery 91.Supplement_6. 2009. 2-9.
6. Durani P and Leaper. Povidone-iodine: use in hand disinfection, skin preparation and antiseptic irrigation. 2008. Int Wound J.;5(3):376-87.
7. Selvaggi G. "The role of iodine in antisepsis and wound management: a reappraisal." Acta Chirurgica Belgica 3. 2003. 241-247.
8. Odimegwu DC, Ibezim EC, Esimone CO, Nworu CS, Okoye FB. Wound healing and antibacterial activities of the extract of Dissotis theifolia (Melastomataceae) stem formulated in a simple ointment base. 2008. J. Med. Plant. Res. 2(1):11-16.
9. Darooyab web site, Phenytoin, Available at: www.darooyab.ir. Accessed Feb 17 2012.
10. Tabiei SH. Effect of sodium Phenytoin on burn wounds healing. Teb and Tazkiyeh. 2000; 31:9-15.
11. Riyahy S, Imany H and Khoshbaten A. Effect of topical application of phenytoin and honey in closure of open wounds in male rats. JAUMS. 2009; 7(2): 73-9.
12. Sehhati Shaffaie F, Rashidi Fakari F, Javadzadeh Y, Ghojazadeh M. Effect of the Phenytoin Cream on Episiotomy Healing in Primipara Women. Journal of Shahid Sadoughi University of Medical Sciences. Vol. 20, No. 2, 2012: 152-58.
13. Gur CS, Erdogan DK, Onbasılar I, Atilla P, Cakar N, Gurhan ID.In vitro and in vivo investigations of the wound healing effect of crude Spirulina extract and C-phycocyanin. J. Med. Plant. Res. 2013; 7(8):425-433.
14. World Health Organization (WHO) (2002). Traditional medicine growing needs and potential. WHO Policy Perspect. Med. 2:1-6.
15. Farhapour M R and Mavaddati A H. Effects of borage extract in rat skin wound healing model, histopathological study. 2012. Journal of Medicinal Plants Research Vol. 6(5), pp. 651-656.
16. Abolhassani M. Antibacterial effect of borage (Echium amoenum) on staphylococcus aureus. Braz Journal of Infectious Diseases. 2004. 8(5): 382-5.
17. Rezaei K, Shahrokhi S S, davoodzade M and Tarrahi M J. The effect of brew of Echium amoenum on urine and blood biochemistry of non-dialysis with chronic renal failure. Quarterly of Lorestan Medical Science University. 2004;20:11-5.
18. Rezaei K, Jebreeili R, Delfan B, Meshkuh M H and Tarrahi MJ. Comparison the effect of Echium amoenum and Steroid on healing and recurrence of Atopic Dermatitis. Quarterly of Lorestan Medical Science University. 2004;21:19-24.
19. Mhamdi B, Wannes WA, Bourgou S and Marzouk B. Bochemical characterization of Borage (Borago Officinalis) seeds. Journal of Food Biochemistry.2009; 33:331–41.
20. Heersaiy A and Farhadpour MR. Borago Officinalis Hydroethanolic Extract improved full thickness wound healing process in experimental animals. International Journal of Biology, Pharmacy and Allied Sciences. 2015; 4(2): 573-82.
21. Hoseini-Tahmasbi M, Hoseini-Tahmasbi S, Karami-dehkordi A, Delaram M, MalekAnzabi J, Fatahi F. Effect of Arnebia euchroma root extract on burn wound healing in Balb/c mice. J Shahrekord Univ Med Sci. 2013 Oct, Nov; 15(4): 54-61.
22. Albina J, Gladden P, Walsh W. Detrimental effects of an omega-3 fatty acid-enriched diet on wound healing. J. Parenter. Enteral. Nutr. 1993 17(6):519-21.
23. Simopoulos AP (1991). Omega-3 fatty acids in health and disease and in growth and development. Am. J. Clin. Nutr. 54(3):438-63.
24. Chung S, Kong S, Seong K, Cho Y. Gamma-Linolenic acid in borage oil reverses epidermal hyperproliferation in guinea pigs. J. Nutr. 2002; 132:3090-7.
25. Cheng MT, Chang MC, Wang ST, Yu WK, Liu CL, Chen TH. Efficacy of dilute Betadine solution irrigation in the prevention of postoperative infection of spinal surgery. Spine. 2005;30:1689-93.
26. Iaghmai M, Heidari S, Shahvan H. Comparison of betadin and normal salines effect in dental silent washing and its result in decrease post dental operation Complications. Dentist college magazine of Shahid beheshti medical university. 2005; 23(4). 683-8.
27. Zahrani Sh, Akbari S, Valaii N. Comparison of betadine and waters effect in episiotomy healing process. Feiz. 2001; 20:80-5.
28. Beldon P .Basic Science of wound healing. Surgery (Oxford) 2010; 28:409-12.
29. Peraza-Snchez SR, Chai HB, Shin YG, Santisuk T, Reutrakul V, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD. Constituents of the leaves and twigs of Ficus hispida. Planta Med 2002; 68(2): 186-188.
30. El-Nahas M, Gawish H, Tarshoby M, State. The impact of topical phenytoin on recalcitrant neuropathic diabetic foot ulceration. Journal of wound care.2009; 18(1):33-7.
31. Shams aldini S, Yavarzade M, Shams aldini A. Comparison of healing effect of phenytoin, Estrogen and Topical Silver sulphadiazine in male rates cutaneous wounds. Journal of cutaneous diseases. 2005; 8(6): 482-8.
32. Shahsavani D, Farhudi M, Movaseghy A and Kiekha F. Clinical and Pathological Study of Effects of Phenytoin Sodium in Gill, Liver and Kidney of Gold Fish. AGIRS. 2007;74:150-5.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
