Volume 21, Issue 5 (NOv-Dec 2013)                   JSSU 2013, 21(5): 575-586 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Entezar-e-Ghaem M, Rahgozar S, Moafi A, Moshtaghian J, Esmaeli A, Abedi M et al . Evaluation of mRNA Expression Profile of ABCG2/BCRP in Childhood Acute Lymphoblastic Leukemia. JSSU 2013; 21 (5) :575-586
URL: http://jssu.ssu.ac.ir/article-1-2191-en.html
Abstract:   (13240 Views)
Introduction: Multidrug resistance (MDR) is the main obstacle against treatment of acute lymphoblastic leukemia (ALL). ATP-binding cassette transporters function is mentioned as one of the most effective factors on MDR development. Though, there are many evidences on interference of ABCG2/BCRP, one of the outstanding members of this superfamly, in MDR occurrence, the expression effect of this gene on blasts of ALL patients is unknown yet. Methods: In this study, we used Real-Time PCR technique in order to investigate the relative expression of ABCG2/BCRP mRNA in 1-17 year old children with ALL. Peripheral or bone marrow blood samples from 28 new case leukemic and 15 control children were investigated with cooperation of Seyyedo-Shohada hospital in Isfahan,. Minimal Residual Disease (MRD) was evaluated as quality of patient response to chemotherapy. Results: Profile of ABCG2/BCRP mRNA expression did not have any significant difference in new case ALL patients in comparison with control children. On the other hand, comparison of two groups of MRD+ and MRD- patients showed no difference in ABCG2/BCRP expression level. The level of ABCG2 expression was not associated with immunophenotype of ALL or known prognosis factors for this type of leukemia. Conclusion: Results of this study showed no effect of ABCG2/BCRP expression level on MDR development in ALL. Accordingly, clinical value of ABCG2/BCRP expression profile determination was rejected as the prognosis value for childhood ALL in our geographical area.
Full-Text [PDF 291 kb]   (2107 Downloads)    
Type of Study: clinical trial | Subject: Genetics
Received: 2012/12/4 | Accepted: 2013/12/7 | Published: 2013/12/7

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | SSU_Journals

Designed & Developed by : Yektaweb