Volume 34, Issue 5 (8-2026)
JSSU 2026, 34(5): 10223-10234 |
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Ethics code: IR.IAU.MSHD.REC.1402.077
Clinical trials code: ندارم
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bababashi M, Baharara2 J, صالحی م, salehi M. Determining the Molecular Mechanisms Regulated by RAD51 and MRE11 Genes in Oocyte Maturation Using Bioinformatics Studies. JSSU 2026; 34 (5) :10223-10234
URL: http://jssu.ssu.ac.ir/article-1-6644-en.html
URL: http://jssu.ssu.ac.ir/article-1-6644-en.html
Abstract: (18 Views)
Introduction: Female infertility is a major challenge in reproductive health, influenced by multiple genetic and molecular factors. This study aimed to investigate the role of RAD51 and MRE11 genes in oocyte maturation and their involvement in molecular networks.
Methods: The protein–protein interaction network was retrieved from the STRING database and analyzed using Cytoscape. The MCODE algorithm was applied to identify functional clusters, and pathway enrichment tools were used to determine relevant biological pathways. Regulatory miRNAs targeting these genes were examined using the miRTarBase database.
Results: Network analysis revealed that BRCA1 and BARD1 act as central hub genes, while ATM and ATRX were identified in key functional clusters by MCODE. Enriched pathways indicated the involvement of these genes in homologous recombination, DNA damage response, cellular senescence, and the cell cycle. Furthermore, miRTarBase analysis showed that several miRNAs, including miR-155 and miR-34a, are capable of targeting RAD51 and potentially regulating its expression.
Conclusion: These findings highlight the critical role of DNA repair–related gene networks in maintaining oocyte quality and suggest that RAD51, MRE11, and their associated pathways could serve as potential therapeutic targets for female infertility.
Methods: The protein–protein interaction network was retrieved from the STRING database and analyzed using Cytoscape. The MCODE algorithm was applied to identify functional clusters, and pathway enrichment tools were used to determine relevant biological pathways. Regulatory miRNAs targeting these genes were examined using the miRTarBase database.
Results: Network analysis revealed that BRCA1 and BARD1 act as central hub genes, while ATM and ATRX were identified in key functional clusters by MCODE. Enriched pathways indicated the involvement of these genes in homologous recombination, DNA damage response, cellular senescence, and the cell cycle. Furthermore, miRTarBase analysis showed that several miRNAs, including miR-155 and miR-34a, are capable of targeting RAD51 and potentially regulating its expression.
Conclusion: These findings highlight the critical role of DNA repair–related gene networks in maintaining oocyte quality and suggest that RAD51, MRE11, and their associated pathways could serve as potential therapeutic targets for female infertility.
Type of Study: Original article |
Subject:
Biology
Received: 2026/02/16 | Accepted: 2026/05/6 | Published: 2026/08/6
Received: 2026/02/16 | Accepted: 2026/05/6 | Published: 2026/08/6
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