Volume 13, Issue 5 (Winter 2006)
JSSU 2006, 13(5): 15-18 |
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Pishva N, Karimi M. A pilot study on the rate of hemoglobinopathies in hyperbilirubinemic term neonates at Nemazee Hospital Shiraz, Iran. JSSU 2006; 13 (5) :15-18
URL: http://jssu.ssu.ac.ir/article-1-558-en.html
URL: http://jssu.ssu.ac.ir/article-1-558-en.html
Abstract: (9640 Views)
Introduction: Neonatal hyperbilirubinemia is a common disorder and if untreated is potentially neurotoxic.
Methods: In order to investigate the correlation between hyperbilirubinemia and hemoglobinopathies, in a prospective study we studied a total 100 full term neonates at Nemazi Hospital with total bilirubin greater than 15 mg/dl and direct bilirubin less than 1.5mg/dl. Other known causes of hyperbilirubinemia such as G6PD deficiency and blood group incompatibility, septicemia and common metabolic disorders were excluded and then hemoglobin electrophoresis was done.
Results: In this study we found two infants with abnormal HbD (2%). None of them had alpha thalassemia or sickle cell anemia.
Conclusion: Hemoglobinopathies can be considered as one of the causes of neonatal hyperbilirubinemia. Further studies are recommended on a larger scale in the form of multi center study.
Keywords: Hyperbilirubinemia, Hemoglobinopathy
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