Volume 27, Issue 3 (7-2019)
JSSU 2019, 27(3): 1302-1312 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Moradi S, Habibi A, Tabandeh M R, SHakerian S. Comparing the effect of 6 weeks of continuous and interval aerobic training on vascular endothelial growth factor and superoxide dismutase enzyme in hippocampus of male rats of Parkinson's model. JSSU 2019; 27 (3) :1302-1312
URL: http://jssu.ssu.ac.ir/article-1-4814-en.html
URL: http://jssu.ssu.ac.ir/article-1-4814-en.html
Abstract: (3400 Views)
Introdution: Based on researches, increased levels of vascular endothelial growth factor and antioxidant parameters in areas of the brain that are more affected by Parkinson's disease have a potential therapeutic effect. Therefore, the purpose of this study was to compare the effect of 6 weeks continuous and interval aerobic exercises on vascular endothelial growth factor and superoxide dismutase enzyme; Parkinson's rats.
Methods: In this experimental study, 24 male Wistar male rats (12 weeks) with an average weight of 250 to 350 grams were used. Subjects were treated with reserpine to Parkinson's, then divided into 6 groups. Aerobic exercises were performed for 6 weeks. After 48 hours of the last training session, the rats were killed, then the tissue of the hippocampus was separated from other parts of the brain, and vascular endothelial growth factor and superoxide dismutase enzyme were measured using specific kits. The results were analyzed using one way analysis of variance analysis and Bonferroni post hoc test.
Results: The results of this study showed that 6 weeks of continuous and interval aerobic exercise increased vascular endothelial growth factor levels in Parkinson's rats (p = 0.01). There was no significant difference between the two groups of interval exercises compared to the continuous training group (p = 0.87). Also, these exercises did not significantly affect the superoxide dismutase enzymes (p = 0.47).
Conclusion: Based on the findings of this study, it has been shown that 6 weeks of continuous and periodic aerobic exercise increases the vascular endothelial growth factor, but these exercises have not significantly changed the superoxide dismutase enzyme.
Methods: In this experimental study, 24 male Wistar male rats (12 weeks) with an average weight of 250 to 350 grams were used. Subjects were treated with reserpine to Parkinson's, then divided into 6 groups. Aerobic exercises were performed for 6 weeks. After 48 hours of the last training session, the rats were killed, then the tissue of the hippocampus was separated from other parts of the brain, and vascular endothelial growth factor and superoxide dismutase enzyme were measured using specific kits. The results were analyzed using one way analysis of variance analysis and Bonferroni post hoc test.
Results: The results of this study showed that 6 weeks of continuous and interval aerobic exercise increased vascular endothelial growth factor levels in Parkinson's rats (p = 0.01). There was no significant difference between the two groups of interval exercises compared to the continuous training group (p = 0.87). Also, these exercises did not significantly affect the superoxide dismutase enzymes (p = 0.47).
Conclusion: Based on the findings of this study, it has been shown that 6 weeks of continuous and periodic aerobic exercise increases the vascular endothelial growth factor, but these exercises have not significantly changed the superoxide dismutase enzyme.
Type of Study: Original article |
Subject:
Exercise Physiology
Received: 2019/02/2 | Accepted: 2019/04/13 | Published: 2019/07/15
Received: 2019/02/2 | Accepted: 2019/04/13 | Published: 2019/07/15
References
1. 1- Lewis S J, Barker R A. Understanding The Dopaminergic Deficits In Parkinson’s Disease: Insights Into Disease Heterogeneity. J Clin Neurosci 2009; 16(5): 620-5.
2. 2- Huang Z, Fuente-Fernández R, Stoessl A. Etiology Of Parkinson's Disease. Can J Neurol Sci 2003; 30(2): 1018.
3. 3- Zigmond M J, Smeyne R J. Exercise: Is It A Neuroprotective And If So, How Does It Work? Parkinsonism Relat Disord 2014 Suppl 1; 20: S123-S7.
4. 4- Yasuhara T, Hara K, Maki M, Matsukawa N, Fujino H, Date I, et al. Lack Of Exercise, Via Hindlimb Suspension, Impedes E Neuro. Neuroscience 2007; 149(1): 182–91.
5. 5- Martinez-Campos C, Lara-Padilla E, Bobadilla-Lugo RA, Kross RD, Villanueva C. Effects Of Exercise On Oxidative Stress In Rats Induced By Ozone. Scientific World J 2012; 2012: 1-5.
6. 6- Cadet J, Last R, Kostic V, Prezedborski S, Jackson-Lewis V. Long Term Behavioral And Biochemical Effect Of 6-OHDA Injection In Rat Caudate Putamen. Brain Res Ball 1991; 26(5): 707-13.
7. 7- Al-Jarrah M. Exercise Training And Rehabilitation Of Brain In Parkinson’s Disease. Clinical Medicine Research 2013; 2(2): 11-7.
8. 8- Scandalis TA, Bosak A, Berliner JC, Helman LL, Wells MR. Resistance Training And Gait Function In Patients With Parkinson's Disease. Am J Phys Med Rehabil 2001; 80(1): 38-43.
9. 9- Urso ML, Clarkson PM. Oxidative Stress, Exercise, And Antioxidant Supplementation. Toxicology 2003; 189(1-2): 41-54.
10. 10- Sutoo D, Akiyama K. Regulation Of Brain Function By Exercise. Neurobiol Dis 2003; 13(1): 1-14.
11. 11- Taub E, Uswatte G, Elbert T. New Treatments in Neurorehabilitation Founded On Basic Research. Nat Rev Neurosci 2002; 3(3): 228-36.
12. 12- firouzehe, keywan (1392), Sports Science, Sports Exercise . [persian]
13. 13- Singh A, Naidu PS, Kulkarni SK. FK506 As Effective Adjunct To L-Dopa In Reserpine-Induced Catalepsy In Rats. Indian J Exp Biology 2003; 41(11): 1264-8.
14. 14- Hubrecht R, Kirkwood J. UFAW Handbook on the care and management of laboratory and other research animals:8th Ed. Wiley-Blackwell publishing Ltd; 2010.
15. 15- Razavinasab M, Shamsizadeh A, Shabani M, Nazeri M, Allahtavakoli M, Asadi-Shekaari M, et al. Pharmacologicalblockade Of TRPV1 Receptors Modulates The Effects Of 6-OHDA On Motor And Cognitive Functions In A Rat Model Of Parkinson's Disease. Fundam Clin Pharmacol 2013; 27(6): 632-40.
16. 16- Brooks GA, White TP. Determination Of Metabolic And Heart Rate Responses Of Rats In Treadmill Exercise. J Appl Physiol Respir Environ Exerc Physiol 1978; 45(6): 1009–15.
17. 17- Lloyd PG, Prior BM, Yang HT, Terjung RL. Angiogenic Growth Factor Expression In Rat Skeletal Muscle In Response To Exercise Training. Am J Physiol Heart Circ Physiol 2003; 284(5): H1668-H78.
18. 18- Ding YH, Luan XD, Li J, Rafols JA, Guthinkonda M, Diaz FG, et al. Exercise-Induced Overexpression Of Angiogenic Factors And Reduction Of Ischemia/Reperfusion Injury In Stroke. Curr Neurovasc Res 2004; 1(5): 411-20.
19. 19- Gustafsson T, Knutsson A, Puntschart A, Kaijser L, Nordqvist SA-C, Sundberg C, et al. Increased expression of vascular endothelial 2012. 444(6):752-9.
20. 20- hashem varzi, A, Heidarianpor A, Study Type: Research | Subject: Preliminary Preparation of Aerobic Exercise Using Vitamin D3 on VEFG Levels of Parkinsonized Mice Using Six-Hydroxy Dopamine Infusion Pysiology No30, Summer. Pages 129-39.
21. 21- Czarkowska-Paczek B, Zendzian- Piotrowska M, Bartlomiejczyk I, Przybylski J, Gorski J. The Influence Of Physical Exercise On The Generation Of TGF-Β1, PDGF-AA, And VEGF-A In Adipose Tissue. Eur j J Appl Physiol 2011; 111(5): 875-81.
22. 22- kordi M R, Nekoie,A ,Shafiee A, The Effect of Continuous and Periodic Aerobic Exercise Exercise on the Expression of Gene of Vascular Endothelial Growth in Neural Muscle in Arami University of Mcl Sciences. 2016 18 (Issue 8), November.
23. 23- churchill JD, Galvez R, Colcombe S, Swain RA, Kramer AF, Greenough WT. Exercise, experience and the aging brain. Neurobiol Aging 2002; 23(5): 941-55.
24. 24- Arida RM, Scorza CA, Da Silva AV, Scorza FA , Cavalheiro EA. Differential Effects Of Spontaneous Versus Forced Exercise In Rats On The Staining Of Parvalbumin-Positive Neurons In The Hippocampal Formation. Neurosci Lett 2004; 364(3): 135-8.
25. 25- JensenH P. Effect of acute exercise an exercise training on VEGF splice variants in human skeletal muscle 2004. molecular human reporoduction, 335- 398.
26. 26- Breen EC, Johson EC, Wagner H, Tseng HM, Sung LA ,Wagner PD. Angiogenic Growth Factor Mrna Responses In Muscle To 2 Single Bout Of Exercise. J Appl physiol 2014; 81 (1): 355-61
27. 27- Coşkun S, Gönül B, Güzel NA, Balabanlí B. The Effects Of Vitamin C Supplementation On Oxidative Stress And Antioxidant Content In The Brains Of Chronically Exercised Rats. Mol Cell Biochem 2005; 280(1-2): 135-8.
28. 28- Huanlou F, Hedayati M, Ebrahimi M, AbedNazari H. The Effect Of Aerobic Exercise In Different Periods On The Changes In The Antioxidant Enzymes Of Rat. J Research in Medical Sci 2011; 35(1):14-9. [Persian]
29. 29- Chang CK, Huang HY, Tseng HF, Hsuuw YD, Tso TK. Interaction Of Vitamine And Exercise Training On Oxidative Stress And Antioxidant Enzyme Activities In Rat Skeletal Muscles. J Nutr Biochem 2007; 18(1): 39-45.
30. 30- Radak Z, Chung HY, Goto S. Systemic Adaptation To Oxidative Challenge Induced By Regular Exercise. Free Radic Biol Med 2008; 44(2): 153-9.
31. 31- Ramsden M, Berchtold NC, Patrick Kesslak J, Cotman CW, Pike CJ.Exercise Increases The Vulnerability Of Rat Hippocampal Neurons To Kainate Lesion. Brain Res 2003; 971(2): 239-44.
32. 32- Aguiar Jr AS, Pinho RA. Effects Of Physical Exercise Over The Redox Brain State. Rev Bras Med Esporte 2007; 13(5).
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
