Volume 24, Issue 10 (Jan 2017)                   JSSU 2017, 24(10): 852-860 | Back to browse issues page

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Jafari M, Mansouri R. A Review on Immunological Diagnosis Methods of Tuberculosis Infection. JSSU 2017; 24 (10) :852-860
URL: http://jssu.ssu.ac.ir/article-1-3801-en.html
Abstract:   (6115 Views)

Tuberculosis (TB) is a leading cause of mortality and morbidity in the world and this infection is a major public health challenge. TB control is largely dependent on the early diagnosis and managements of suspected cases. Today, for laboratory diagnosis of TB infection, several bacteriological and immunological methods such as sputum smear microscopy, sputum culture and tuberculin skin test are used.  Although they have not been very successful in decreasing TB cases as expected. In recent decades, tuberculin skin test or Mantoux test has been used as a screening and diagnosing method; low specificity and sensitivity are main shortcoming of this method. In the recent years, in order to modifying mentioned defects, interferon gamma release assays (IGRAs) have emerged as an immunodiagnostic tool to detect latent tuberculosis. In this review, we discuss the advantages of new immunologic tests in diagnosis of TB.

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Type of Study: Review article | Subject: Immunology
Received: 2016/07/3 | Accepted: 2016/09/10 | Published: 2017/02/19

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