Volume 24, Issue 3 (Jun 2016)                   JSSU 2016, 24(3): 286-293 | Back to browse issues page

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Mohammadiyan M, Bahaoddini َ, Mohammadi J, Ebrahimiyan H. The effect of hydroalcoholic extract of olea europea L. Leaf on Blood pressure and its interaction with adrenergic system of male rats. JSSU 2016; 24 (3) :286-293
URL: http://jssu.ssu.ac.ir/article-1-3592-en.html
Abstract:   (8944 Views)

Introduction: Hypertension is one of the most common and important disease factors imposed by the modern lifestyle, in particular by reduced physical activity and an unbalanced lipid-rich diet. One of the best methods for treatment of hypertension is the use of medical herbs that have moderate effects on blood pressure such as Olive (Olea europea L.). Therefore, the purpose of this study was to evaluate the effect of hydroalcoholic extract of olea europea L. Leaf on blood pressure and its interaction with adrenergic system of male rats

Methods: In this experimental study, 10 adult male wistar rats weighing between180-250g were used. They were divided into two groups (each group contained 5 rats) randomly: olive leaf extract group and olive leaf extract and adrenaline group. Then, each rat was anesthetized by IP injection of 1.2 g/kg urethane. After tracheostomy, the femoral vine and artery were cannulated for drug injection and blood pressure recording respectively. Arterial cannula for recording arterial blood pressure connected to a pressure transducer linked to Power lab. Blood pressure parameters (systolic, diastolic and mean arterial pressure) were recorded before and after IV administration of hydroalcoholic extract of olea europea L. leaf, solvent, adrenaline and olive leaf extract with adrenaline.The data were analyzed using SPSS software.

Results: The results showed a significant decrease of systolic, diastolic and mean arterial pressures in comparison with the control and sham groups (P<0.05). Also, a significant decrease of blood pressure showed in presence of olive leaf extract and adrenaline with compare to the sham group (P<0.05).

Conclusion: It can be concluded that olea europea L. leaf may suggested as a hypotensive agent. It seems that this effect is due to the inhibition of the adrenergic system

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Type of Study: Original article | Subject: Physiology
Received: 2016/01/26 | Accepted: 2016/07/9 | Published: 2016/09/11

References
1. Perrinjaquet-Moccetti T, Busjahn A, Schmidlin C, Schmidt A, Bradl B, Aydogan C. Food Supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytother Res 2008; 22: 1239-42
2. Abdali A, Hosseini-Mazinani M, Ataei S, Hosseini S, M Naghavi MR. Studies on intra-cultivar variation of four iranian olive cultivars using morphological characteristics and RAPD markers. Iranian J Bio 2012; 24(6): 868-79. [Persian]
3. Jaymand K, Rezaei MB, Abravesh Z, Golipour M, Sharifi M. [Extraction and determination of oleuropein in nine varities of olea europaea l. Cultivated in fadak research station (dezful)]. Iranian J Med Aromatic Plants 2006; 22 (1). [Persian]
4. Sada mtz A. Olive leaf. Altern Med Rev 2009; 14(1): 62-6.
5. Al- Azzawie HF, Alhamdani M. Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits. Life Sci 2007; 78: 1371-77.
6. Erbay Z, Icier F. The importance and potential use of olive leaves. Food Rev Int 2010; 26: 319-34.
7. Malik N, M Bradford. Recovery and stability of oleuropein and other phenolic compounds during extraction and processing of olive (Ole europaea L.) leaves. J Food Agr Environ 2008; 6(2): 8-13.
8. Gilani AH, Khan AU. Medicinal value of novel combination of cholinergic and calcium antagonist constituents in olive. In: Olives and Olive Oil in Health and Disease Prevention. Amsterdam, the Netherlands: Academic Press Elsevier 2009 .p. 835-43.
9. Nekooeian AA, Khalili A, Khosravi MB. Effects of oleuropein in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms. J Asian Nat Prod Res 2014; 23: 1-10.
10. Silambarasan T, Raja B, Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats. Eur J Pharmacol 2012; 679: 81-9.
11. Zeggwagh NA, Moufid A, Michel JP, Eddouks M. Hypotensive effect of chamaemelum nobile aqueous extract in spontaneously hypertensive rats. Clin exp hypertens 2009; 31(5): 440-50.
12. Zeggwagh NA, Michel JP, Eddouks M. Vascular effects of aqueous extract of chamaemelum nobile: in vitro pharmacological studies in rats. Clin exp hypertens 2013; 35(3): 200-06.
13. Al-Snafi AE. Medical importance of anthemis nobilis (chamaemelum nobile). AJPST 2016; 6(2): 89-95.
14. Ko F, Huang T, Teng C. Vasodilatory action mechanisms of apigenin isolated from Apium gratueolens in rat thoracic aorta. Biochim Biophys Acta 1991; 1115: 69-74.
15. Duarte J1, Pérez Vizcaíno F, Utrilla P, Jiménez J, Tamargo J, Zarzuelo A. Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships. Gen Pharmacol 1993; 24(4): 857-62.
16. Visiolil F, Bellosta S, Galli C. Oleuropein, the bitter principle of of olives, enhances nitric oxide production by mouse macrophages. Life Sci 1998; 62(6): 541-46.
17. Mansoori Bahrani AH, Zaheri H, Soltani N, Kharazmi F, Kheshavarz M, Kamalinajad M. Effect of the administration of Psidium guava leaves on blood glucose, lipid profiles and sensitivity of the vascular mesenteric bed to Phenylephrine in streptozotocin-induced diabetic rats. Int J Diabetes Mellit 2012; 2(1): 138-45.
18. Gilani AH, Khan A, Shah A, Connor J, Jabeen Q. Blood pressure lowering effect of olive is mediated through calcium channel blockade. Int J Food Sci Nutr 2005; 56(8): 613-20.
19. Zhang Y, Park Y, Kim T, Fang L, Ahn H, Hong J, et al. Endothelium-dependent vasorelaxant and antiproliferative effects of apigenin. Gen Pharmacol 2002; 35: 341-47.
20. Ajay M, Gilani AU, Mustafa MR. Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sci 2003; 74(5): 603-12.

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