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Introduction: Diabetes is one of the most prevalent metabolic diseases in the world. It affects 6.6% of world population and about 3 million individuals in Iran. Cumin (Cuminum Cyminum L) is a plant used in traditional Iranian medicine to cure obesity, and some recent studies have suggested that Cumin could have a role in diabetes treatment and reduction of lipid levels. In this study, we investigated the Cumin oil effects on serum glucose and lipid levels of rats. Methods: We divided 24 male rats of Wistar race into 6 hexadic groups the control group with normal regimen(group a), the Cumin oil group with normal regimen(group b), the control group with high fat regimen(group c), the Cumin oil group with high fat regimen(group d). The consumed dosages of Cumin oil were 400 µg/kg and 3mg/kg, respectively which was administered by Gavages (tube feeding). Samples from the hungry rats were taken during three various periods including the first day of the study, 20th day (the beginning of the medicine usage) and 55 th day (the end of the medicine usage) in order to measure their serum glucose and lipid levels. Results: The results of this study showed a significant decrease in glucose(p=0.007), cholesterol(p=0.001), triglyceride(p=0.002), LDL (p=0.004) levels and a significant increase in serum HDL levels(p=0.05). Conclusion: Cumin oil administered via Gavages can significantly affect the serum glucose and lipid levels.

Keywords: Cuminum; Glucose; Lipids; Cholesterol, HDL; Cholesterol, LDL

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