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Introduction: Hypothermia is used as an adjunct in surgery of different organs including heart, liver, brain and thyroid .It can be produced by different techniques such as superficial cooling ,cooling of blood and pharmacological cooling . Hypothermia has several effects on function of different organs and tissues including heart, lung ,liver, brain ,thyroid and vascular system .In this study, the histological and biochemical effects of hypothermia on liver in rats have been investigated . Materials & Methods : This study was an intervention experimental study . Results: Superficial hypothermia was produced with the aid of hypothermia system by placing rats in it . Wistar rats were chosen as an animal model. Rats were anesthetized using 10% Hydrate chloral and placed in very deep hypothermia (20c1) for 4.5 hours. In the first group, blood sampling was carried out immediately after the hypothermia period. In the second, blood sampling and specimens were obtained 24h later. The histological studies of the liver showed that the nuclei of hepatocytes had become vesicular and the sinusoidal spaces were decreased. The serum levels of GPT were increased in the first group. But the serum levels of GOT were increased in both groups. Conclusion: The results indicate histological and biochemical effects of hypothermia on liver. It appears that the vascular changes induced by hypoxia are responsible for the effects of hypothermia.

Keywords: hypothermia, liver, GPT, GOT

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