Volume 18, Issue 1 (March-April 2010)                   JSSU 2010, 18(1): 17-23 | Back to browse issues page

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Roghani M, Baluchnejad Mojarrad T, Andalibi N, Ansari F, Sharayeli M. Effect of Consumption of Tribulus Terrestris on Serum Glucose and Lipid Levels in Diabetic Rats. JSSU. 2010; 18 (1) :17-23
URL: http://jssu.ssu.ac.ir/article-1-1005-en.html
Abstract:   (8822 Views)
Introduction: The effect of Tribulus terrestris (TT) on serum glucose and lipid levels was investigated in an experimental model of diabetes mellitus in rats. Methods: Female Wistar rats were divided into control, TT-treated control, diabetic, glibenclamide-treated, and TT-treated diabetic groups. For induction of diabetes, streptozotcin (STZ) was administered (60 mg/Kg). Meanwhile, TT-treated groups received TT mixed with standard pelleted food at a weight ratio of 6.25% for 6 weeks. Serum glucose and lipid levels were determined before the study and at the 3rd and 4th week after the study. Results: Serum glucose was significantly lower in TT-treated diabetic rats at 3rd and 6th weeks as compared to untreated diabetics (p<0.01 and p<0.005, respectively). In addition, serum total cholesterol, triglyceride, and LDL-cholesterol showed a significant reduction in TT-treated diabetic rats as compared to untreated diabetics (p<0.05). On the other hand, HDL-cholesterol level did not change significantly in TT-treated diabetic group as compared to untreated diabetic group. Conclusions: Oral administration of TT has a significant hypoglycemic effect and in long term leads to appropriate changes in serum LDL-cholesterol, total cholesterol, and triglyceride levels, but does not affect HDL-cholesterol levels in diabetic rats.
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Type of Study: Original article | Subject: General
Received: 2010/03/15 | Published: 2010/04/15

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