Showing 4 results for Osteocalcin
Khorshidi, Matinhomaee, Azarbayjani , Hossein-Nezhad ,
Volume 19, Issue 5 (12-2011)
Abstract
Introduction: The purpose of this study was to investigate the effects of a ten week period of aerobic exercise training on serum alkaline phosphates and osteocalsin in type 2 diabetic patients.
Methods: In a quasi-experimental trial study twenty one male patients with type 2 diabetes(40-50 years) were randomly divided into exercise(n=11) and control(n=10) groups. The exercise group underwent a 10-week aerobic exercise program(three sessions per week, 45-60 minutes each session, at 50-65% of heart rate reserve). VO2max, BMI, fasting blood glucose and serum insulin, alkaline phosphatase and osteocalcin were measured at baseline and after exercise program.
Results: Exercise program resulted in a significant increase in VO2max and a significant decrease in BMI, fasting blood glucose and HbA1c in exercise group however, no significant changes were found in the insulin concentration, alkaline phosphatase and osteocalcin. The bone formation markers and other measured variables did not show significant change in control group.
Conclusion: These results suggest that aerobic exercise leads to glycemic improvement in type 2 diabetic patients, but does not affect serum levels of alkaline phosphatase and osteocalcin.
Mh Eftekhari, Z Hassanzadeh Rostami, Mj Emami, Hr Tabatabaee,
Volume 21, Issue 5 (12-2013)
Abstract
Introduction: Magnesium is an essential mineral in bone formation. This nutrient incorporates in bone metabolism and enhances bone mineralization. This study was designed to assess the effect of magnesium supplementation on alkaline phosphatase , osteocalcin, and also callus formation in women with long bone fracture.
Methods: In this double-blind randomized placebo controlled trial, 32 women with long bone fracture, aged 20-45 years old, were randomly divided into the Mg group and control, receiving 250 mg magnesium oxide daily and placebo respectively for 8 weeks. Serum alkaline phosphatase and osteocalcin were measured at the beginning and the end point, and also callus formation was checked at the end of study. P value < 0.05 was considered as the significant level.
Results: There was no significant difference between two groups in alkaline phosphatase and osteocalcin levels at the beginning and the end of study. Serum alkaline phosphatase and osteocalcin levels were increased in both groups, but they were not statistically significant. Furthermore, the callus formation, which revealed the fracture healing, was not different between 2 groups.
Conclusion: This study concluded that Magnesium supplementation did not change the serum markers of bone formation and fracture healing however, further studies need to approve this finding.
Mehdi Rostamizadeh, Alireza Elmieh, Farhad Rahmaninia,
Volume 27, Issue 5 (10-2019)
Abstract
Introdution: The cells rolled in the formation of bone, regulated glucose metabolism, and increased insulin secretion from pancreatic beta cells and modulated the insulin resistance. Therefore, the present study aimed to study the effects of aerobic and resistance exercises on relation between blood biochemical parameters and body composition with bone turnover markers in overweight men.
Method: In this quasi-experimental study, a total of 36 overweight, young healthy men (age range28-35 years) were randomly assigned to the control (n=14), aerobic exercise (n=11) and resistance exercise (n=11) groups. In the aerobic exercise group, excercisetraining was performedfor 8weeks, three sessions per week (at 55-85% of HRR), and in the resistance exercise group,exercise training was perfprmed in 8weeks for three sessions per week(at 55-75% of 1RM). Body composition and blood samples were assessed from fasting blood samples before and after the 8-week exercise programme. Data wereanalyzed by t-test and ANOVA by SPSS ver.25 Software.
Results: Paired t-test and one-way ANOVA showed that aerobic and resistance training cause the reduction of body composition (P <0.05), increasing the osteocalcin (P = 0.001 and P <0.001) as well as a significant decrease in blood biochemical parameters (P <0.05). Also, Pearson correlation showed that there was no correlation between osteocalcin and blood biochemical parameters and body composition (P <0.05).
Conclusion: The results of this study showed that 8 -week exercise trainings increase osteocalcin levels, which is associated with a decrease in body weight and body fat percentage, particularly lipid profiles. However, despite the differences in mean, there was no statistically significant difference between aerobic and resistance training.
Ramin Eimari Eskandari, Hassan Matin Homaee, Lida Moradi,
Volume 29, Issue 7 (10-2021)
Abstract
Introduction: Free radicals increase with age and disease, so the aim of this study was to investigate the effect of exercise and vitamin D on the expression of alkaline phosphatase and osteocalcin genes in bone tissue of rats poisoned with hydrogen peroxide.
Methods: In this experimental trial, 36 adult male Wistar rats were randomized into six groups of six rats, 1) control; 2) hydrogen peroxide; 3) hydrogen peroxide + vitamin D; 4) hydrogen peroxide + exercise; 5) hydrogen peroxide + exercise and vitamin D and 6) Sham. For eight weeks, groups 2, 3, 4, and 5 were given daily dose of 1 mmol/kg hydrogen peroxide on even days, groups 3 and 5 received 0.5 mg / kg of Vitamin-D daily, and sham group received only vitamin D solvent intraperitoneally. Groups 4 and 5 performed aerobic exercise 3 day/week. Osteocalcin and alkaline phosphatase gene expression were measured by PCR and were analyzed using independent t-test, two-way analysis of variance and Boferroni’s post hoc test with SPSS 16 (p≤0.05).
Results: The interactive effect of exercise and vitamin D on increasing alkaline phosphatase and osteocalcin was significant. (p≤0.05); exercise increased alkaline phosphatase and osteocalcin (p ≤ 0.05); vitamin D was also associated with increased alkaline phosphatase and osteocalcin (p=0.0001). The greatest effect on increasing osteocalcin and alkaline phosphatase showed in groups 5 and 3, respectively (p=0.001).
Conclusion: Exercise and vitamin D had a positive effect on bone tissue, so that even the systemic effect of hydrogen peroxide could not change the results of this constructive effect.
