Showing 21 results for Multiple Sclerosis
Gh Mosayebi, A Ghazavi, Ma Payani ,
Volume 15, Issue 1 (4-2007)
Abstract
Introduction: Multiple sclerosis (MS) is a chronic autoimmune disease with unknown etiology affecting the central nervous system. The prevalence of MS is highest where environmental supplies of vitamin D are lowest. Some studies have shown a strong protective effect of vitamin D3 in experimental autoimmune encephalomyelitis (EAE) a model of MS. However, it is not known whether vitamin D3 has a protective effect in EAE. Vitamin D3 may be inhibit EAE by having an effect on TH1 and TH2 immune responses. To address this question, the effect of vitamin D3 on cellular immune responses in C57BL/6 mice with experimental autoimmune encephalomyelitis was investigated.
Methods: Male C57BL/6 mice matched in age and weight were placed in two therapeutic groups (n=10 per group) as follows: Vitamin D3-treated EAE mice (5μg/kg/every two days of vitamin D3 given i.p from day -3 until day +19 after disease induction). Non-treated EAE mice (EAE control) received vehicle alone with same schedule. 20 days after immunization, the mononuclear cells (MNCs) of the spleen were isolated from mice and cultured in the presence and absence of MOG35-55 for 96 hours. The supernatant of cultured cells was collected and produced cytokines (IL-10 and IFN-γ) were assayed by ELISA.
Results: The results showed that vitamin D3-treated mice had less severe clinical signs and synptoms of EAE (3.2±0.8) than non-treated EAE induced mice (5.3±0.44), (p=0.001). Also, there was a significant difference regarding the day of onset of disease in the vitamin D3-treated and non treated EAE-induced mice (day 15±1 and day 11±1, respectively).
There was no significant difference in IFN-γ production between treated and non-treated mice, but the amount of IL-10 production in the D3-treated mice was higher than the non-treated group (p=0.001).
Conclusion: Considering the role of TH1 in the pathogenesis of EAE and MS, it is suggested that vitamin D3 can reduce or delay the onset of EAE by shifting immune responses to TH2 and IL-10 production. Thus, vitamin D3 as an immune modulatory agent is potentially important for treatment of MS
S Hamidizadeh, R Masoodi, Fa Ahmadi, E Mohammadi,
Volume 17, Issue 2 (7-2009)
Abstract
Introduction: Multiple sclerosis is a chronic, progressive and degenerative myelin sheath disease of the central nervous system. It frequently occurs in young people in the productive stage of life who are solicitous about their role and family responsibilities. One of the treatment and vigilance intervention index in improvement of chronic illness is quality of life. The objective of the implementation of this study was to assess the effect of Orem self- care program on physical quality of life in multiple sclerosis patients.
Methods: This study was a quasi-experimental research on 70 multiple sclerosis patients’ who were randomly allocated to experimental or control group (35 patients in each group). The experimental group was treated with self-care program based on Orem self-care frame work and compared with the control group. Data was analyzed using presumption statistics.
Results: T test showed that there was no significant difference in the physical quality of life score before intervention in the two groups (P=0.33, T=-0.69), while after intervention, the same test indicated a significant difference between the two groups (P=0.001, T=14.42). Pair t test showed significant difference in experimental group before and after self care program (P=0.001, T=-14.20), whereas the same test showed no significant difference in the control group (P= 0.95, T= -0.06).
Conclusion: According to the study result, self care program based on the Orem frame work can have an effect on the physical quality of life in multiple sclerosis patients. Therefore, if a program is designed on the basis of educational needs and the “Orem self- care model” approach, it can be effective for enhancing the multiple sclerosis patients physical quality of life, and it can be recommended as a nursing interventional program. This intervention is safe, inexpensive and complementary that can be used to support multiple sclerosis patients in treatment centers.
F Rashvand, Z Moshtagh Eshgh, M Farvid, M Abtahi, Z Amiri, H Madani,
Volume 19, Issue 3 (8-2011)
Abstract
Introduction: Multiple Sclerosis Disease is the most common neurological demyelinization disorder in young adults that leads to their disability. Because of the side effects of treatment drugs, it seems that another method should be used. Correct nutrition is one of these methods. The aim of this research was to determine the effects of nutrition on activity of daily living in MS patients referring to the Iranian MS society in 2010.
Methods: In this quasi- experimental study (before and after investigation), 40 MS patients were selected on basis of purposive and accessible sampling method. The data was collected via questionnaires. The intervention comprised of correct nutrition algorithm education for 12 weeks. All questionnaires were filled before and after the intervention by subjects and then pre/post intervention data was analyzed with SPSS 16 software. Statistical tests included Student paired and T tests.
Results: The statistical analysis showed that there was a significant difference between mean score of ability of activity of daily living of MS patients before and after intervention(P<0.001), thus confirming the hypothesis of the study.
Conclusion: According to results, it is recommended that nutrition pattern (simple, cheap without side effects and noninvasive procedure) should be used to improve the levels of activity of daily living in MS patients.
N Hasan Neghad, F Hadavand Khani, P Ahmadi, Z Khanjani,
Volume 21, Issue 4 (10-2013)
Abstract
Introduction: Psychological hardiness is a personal factor and social support is regarded as an environmental factor that can facilitate adjustment to disease. This study aimed to investigate the relationship between adaptation with psychological hardiness and social support in individuals with Multiple sclerosis (MS).
Methods: Seventy two females with MS and 25 males with MSwere selected through randomized sampling from two MS centers. Main variables of the study including adaptation, psychological hardiness, and social supportwere assessed respectively by Adaptation Inventory, Personal Attitudes Survey, and Social Support Questionnaire.
Results: Spearman correlation coefficients revealed that there are significant relationships between adaptation and psychological hardiness (p<0.0001), as well as between adaptation and social support (p<0.0001). In addition, Multiple linear Regression showed that psychological hardiness (β= -0.483) and social support (β= -0.240) can explain 35/1% of adaptation variance in individuals with MS. Psychological hardinessproved to have a more important role in adaptation of individuals with MS.
Conclusion: The study data demonstrated that personal factors like psychological hardiness and environmental factors such as social support can predict adjustment in individuals with MS. In order to clarify mechanisms of these factors on adaptation in individuals with MS, morelongitudinal and experimental studiesare required. These results are alsoapplicable in designing therapeutic programs for individuals with MS.
A Atefi, Mh Shahhosseiny, K Bidoki, R Mansouri, F Binesh, A Atefi, M Vassei,
Volume 21, Issue 6 (2-2014)
Abstract
Introduction: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS). It is an Auto immune disease whose cause is still unknown though some factors can be named as its cause such as genetics, geographic element and viral agents. HSV is among the infection agents that may be involved in pathogenesis of MS. The aim of this study was to use a new technique called loop-mediated isothermal amplification to detect presence of Herpes Simplex Virus in patients harboring Multiple Sclerosis as well as in healthy individuals in the control group.
Methods: This study is a cross-sectional analytical study in which 50 multiple sclerosis patients and 50 healthy controls were included. The infection with herpes simplex virus types 1 and 2 was investigated by the new technique of LAMP.
Results: The sensitivity of this technique was 5 particle viruses and its specificity for HSV was 100%. Within the 50 patients with multiple sclerosis, 11 samples revealed positive results for HSV (22%), while in the control group no infection with herpes simplex virus was found (0%).
Conclusion: This study indicates that the LAMP technique owns high sensitivity and specificity for detection of herpes simplex virus types 1 and 2 in serum of patients with multiple sclerosis as well as the control group.
B Tirgary, M Tofighi, M Azizzadeh Foroozy, S Iranmanesh, H Tehrani,
Volume 22, Issue 1 (4-2014)
Abstract
Introduction: Multiple Sclerosis is the most common non - traumatic illness of central nervous system. Due to debilitating nature of the disorder, and its unpredictable progress, there is a great deal of uncertainty about the future health and well-being of MS sufferers. Therefore, this study aimed to assess the perceived uncertainty in patients with MS.
Methods: This is a cross-sectional descriptive study. The study population consisted of 200 non- hospitalized patients With Multiple Sclerosis. Convenience sampling was applied in this study and data was collected via a questionnaire including background information and MUIS-Community questionnaire consisting of 23 items about uncertainty. Data analysis was performed by T-test and ANOVA test.
Results: Results showed that the most active patients (5/79%) were females and 5/67% were married. Overall mean score of uncertainty scale was 67.20 (12/35). The results related to uncertainty dimensions revealed that mean score of ambiguity was 32.24, mean score of complexity was 11.80, mean score of inconsistency was 4.79 and unpredictability was 2.78. The results related to relationship between perceived uncertainty and demographic factors show significant difference between the education level and residence with perceived uncertainty and ambiguity.
Conclusions: Considering that MS patients experience the high levels of uncertainty that it will lead to depression and stress, therefore, with the emphasis on rigorous assessment of patient health and holding educational classes of uncertainty management especially for people with lower education level can be an effective step to reduce stress and depression in patients with Multiple Sclerosis.
R Rahnama, R Mansouri, H Valizadeh, A Rahimdel, G Eslami,
Volume 22, Issue 6 (2-2015)
Abstract
Introduction: Multiple sclerosis (MS) is a demyelinating disease of central nervous system. Lack of regulation in inflammatory responses is considered to be a key element in the auto reactive immune response in MS. The FOXP3 transcription factor is predominantly expressed by the Treg cell lineage and appears to act as a master regulator of effector T cell activation. Therefore, this study aimed to investigate the possible association between single nucleotide polymorphisms (SNP) in the FOXP3 gene and predisposition to MS.
Methods: This case-control study consisted of 115 MS patients and 115 healthy controls, which were genotyped for the SNP rs 3761549. RFLP analysis was performed using AluI restriction enzyme.
Results: The frequency of A allele was 15.6% in patients and 98.3% in normal controls (p=0.33). Moreover, allele G was identified as 98.1% in MS cases and 11.3 in controls. The rs 3761549(GG) was found in 84.3% of MS patients and in 88.7% of controls (p=0.33), rs 3761549 (AA) was found in 0.9% of MS cases and in 1.7% of controls (p=0.5), rs 3761549 (AG) was observed in 84.4% of MS cases and in 88.7% of controls (p=0.27). No significant difference was observed between patients and controls in regard with alleles and genotypes.
Conclusion: The results of the present study suggest that the mentioned functional polymorphism is not likely to cause susceptibility to MS.( OR= 0.678 95% CI= 1.477-0.0319)
A Jazaeri, A Karimi Moghadam , S Vallian Borujeni ,
Volume 23, Issue 10 (1-2016)
Abstract
Introduction: Multiple sclerosis (MS) is an acute disease of the central nervous system (CNS) associated with the degradation of myelin sheet around the nerve cells. It is assumed to be a multifactorial disorder that is to say numerous environmental and genetic factors are involved in the disease. Therefore, this study aimed to investigate the association between rs1800624 single nucleotide polymorphism (SNP), located in the promoter region of RAGE gene, and MS in Isfahan population.
Methods: In this case-control study, tetra-primer ARMS PCR and newly designed primers were utilized in genotyping and determining allele frequency of rs1800624 SNP marker. A total of 300 individuals including 150 healthy and 150 MS patients participated in the study. In order to evaluate the association between genotypes and MS as well as the existence of Hardy-Weinberg equilibrium, SPSS and GENPOP softwares were used, respectively.
Results: The study results showed that the frequency of TT, TA and AA genotypes were reported 42.7, 46.6 and 10.7 in the control group and 44, 42 and 14 in the case group. The studied population was in equilibrium in regard with rs1800624 marker. Moreover, no association was detected between rs1800624 marker and MS disease in the Isfahan population (p>0.5).
Conclusion: The study findings indicated no association between SNP marker of rs1800624 and MS disease in the Isfahan population (p>0.5).
P Ahmadi-Shooli , Ar Feily, Islamic Azad University S Behzadipour,
Volume 23, Issue 10 (1-2016)
Abstract
Introduction: Multiple sclersis (MS) can involve approximately all aspects of life, which leads to different problems for a person such as psychological problems. Therefore, the present study
aimed to evaluate effectiveness of mindfulness-based therapy on the mental health of female patients suffering from MS.
Methods: In this quasi-experimental study, the study sample consisted of 24 patients suffering from MS, who were selected via convenience sampling method. Once the participants were homogenized in regard withg their age, occupation, and education, they were devided into an experimental group (n=12) and a control group (n=12). The study instrument consisted of the general health questionnaire (GHQ-28). The experimental group attended 8 sessions—each lasting 2 hours—of training on mindfulness-based cognitive therapy, whereas the control group did not receive any interventions. In order to analyze the study data, SPSS software( ver, 22) was used via Multivariate analysis of co-variance (MANCOVA).
Results: As the study results demonstrated, the difference between experimental and control groups was proved to be significant in terms of mean scores of mental health and its dimensions (p=0.0001).
Conclusion: The study results supported the effectiveness of mindfulness – based cognitive therapy on mental health of female patients . It can be concluded that this method has ameliorated mental health of MS patients.
Fereshteh Eftekhary, Mostafa Payandeh, Mahdi Savadi,
Volume 25, Issue 10 (1-2018)
Abstract
Introduction: Patients with multiple sclerosis (MS) suffer from inabilities such as weakness and muscle fatigue. This is due to the demyelination, disorder of the central nervous system, axons and oligodendrocytes. Free moment assess is known as important descriptor to investigate disorders with balance when walking. The purpose of this study was to evaluate the free moment in during walking that represents balance disorders in patients with multiple sclerosis.
Methods: This study was a cross sectional study, that was performed on 30 people; they were divided into two groups, the patients with multiple sclerosis (n = 15) and healthy groups (n = 15). The free moment component was measured in all the participants while they were walking throughout the four moments of initial heel contact, loading response, mid stance, and terminal stance of the stance phase with a frequency of 1000 Hz, by means of force plates. The data of the study were analyzed by an independent t-test (p < 0.05).
Results: The results showed that the individuals with multiple sclerosis at the time of initial heel contact have been greater free moment than to healthy control. That the free moment difference between the two groups was statistically significant (p = 0.02). In addition, the results this study showed that the three other free moments in the stance phase there was no significant difference (p >0.05).
Conclusion: The results of this study can be concluded that most differences in postural sway when walking between subjects with multiple sclerosis and healthy occurs at the start of the stance phase of gait, exactly at the time of initial heel contact.
Javad Khalatbari, Farzaneh Noroozi, Mr Vahid Hemmati Sabet, Mohammad Ebrahim Maddahi,
Volume 26, Issue 5 (8-2018)
Abstract
Introdution: The aim of this study was to investigate the mediating role of cognitive emotion regulation strategies on the relationship between attachment styles and quality of life in the patients with multiple sclerosis in Tehran.
Methods: The research method was descriptive-correlational. The statistical population of the study was all the patients with multiple sclerosis referred to Sina Hospital in Tehran in 1396. By using the sample size calculations in structural equations and available sampling method, 354 participants were selected as a sample size. In order to measure the variables, the cognitive emotion regulation strategies Questionnaire (Garnefski et al., 2001) (), Hazan and Shaver Attachment Styles (1990) and World Health Organization Quality of Life (1997) were used. The proposed model was evaluated by structural equation modeling using SPSS21 and Smart-Pls 2 and Amos-22 softwares. The technical characteristics of the questionnaire, including reliability, convergent validity and divergent validity were investigated. Moreover, path coefficients and software significance coefficients were used to examine the research hypotheses.
Results: The results of the present studyshowed that cognitive emotion regulation strategies have a mediating role in attachment styles and quality of life.
Conclusion: Therefore, the results of the study can lead to a better understanding to promote mental health after the onset of multiple sclerosis
Maryam Vatandoust, Pezhman Motamedi, Hamid Rajabi, Ata Allah Ghadiri,
Volume 26, Issue 7 (10-2018)
Abstract
Introdution: According to importance of complimentary therapies. This study was conducted to investigate the effect of a four-week aerobic physical activities in water on the extent of clinical improvement and amount of Tumor Necrosis Factor alpha, TNF-α, Interleukin 10, IL-10 on serum levels and brain-derived neurotrophic factor in the brain tissue of the animal model of of multiple sclerosis (MS) via inducing experimental autoimmune encephalomyelitis (EAE).
Methods: In this experimental study, a total number of 80 female Syrian mice from the race of C57BL/6,, aging 10 to 12 weeks and weighing 20 ± 2 gram were divided into eight groups of 10, namely, control, swimming, MS, MS + swimming, MS + interferon beta (INF-β), MS + interferon beta + swimming, MS + solvent, and MS + solvent + swimming environment. For induction of EAE, 300 μg (35-55) myelin oligodendrocyte glycoprotein (MOG) was first mixed in 100 μl phosphate buffered saline (PBS) with complete Freund's adjuvant (CFA) and injected subcutaneously (SC). At the time of injection and after 48 hours, 300 ng pertussis toxin was diluted in PBS and injected intraperitoneally (IP). During a week after the treatment, mice receiving were the drug in form intraperitoneal received 150 IU/g of the drug per day. Clinical symptoms and the mice's weights were recorded every day. Physical activity group did the aerobic activities for four weeks, five sessions a week, 30 minutes each session. Finally Brains were extracted and blood samples were taken from the heart and enzyme-linked immunosorbent assay (ELISA) was applied to measure markers. Data analysis was done using one-way ANOVA.
Results: Based on the findings of this study, physical activity compared to interferon beta-1 treatment significantly increased the BDNF factor in mice, increased IL-10, and decreased TNF-α in serum .
Conclusion: Aerobic swimming exercises could most probably help remyelination by regulation of inflammatory factors and lowering the speed of myelin destruction, hence, helping the clinical improvement in patients with multiple sclerosis.
Fariba Banitalebi, Somayeh Reiisi,
Volume 26, Issue 9 (12-2018)
Abstract
Introdution: Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system. Nevertheless, the causal etiology of MS is not fully revealed and there are some neurological disorders that might have similar phenotypic manifestations with MS. Therefore, reliable and available diagnostic method is very necessary for differential diagnosis. The use of new biomarkers for faster diagnosis and selection of more efficient therapies is one of the main concerns in this area. Few studies have been conducted on the effects of miR-140-5p in T cell development. Therefore, to determine the role of this miRNA in MS, this study was directed to investigate the expression level in MS samples and its relationship with clinical factors.
Methods: In this study, expression level of miR-140-5p was evaluated in 40 MS patient and 40 health individual by using qPCR. Followed total RNA extraction, expression was investigated by miRNA specific primers by stem-loop method and then statistical analysis was accomplished to define the significance. In the next step, the correlation between clinical factors and miRNA expression was considered.
Results: The results of the present study showed that relative expression of miR-140-5pwas significantly decreased in MS patient compared with the control group (P<0.001).
Conclusion: As a result, miR-140-5p may contribute to MS disease, so that decrease in its expression is associated with increased disability. Further investigation can help to suggest this miRNA as diagnostic biomarkers or therapeutic targets in MS.
Ms Somayeh Abdi, Homeira Hatami Nemati, Roghayeh Khakpay, Gholamreza Dehghan,
Volume 26, Issue 11 (3-2019)
Abstract
Introduction: The aim of this study was to investigate the effect of short-term microinjection of Ferula szowitsiana extract on the process of spatial memory and lipid peroxidation in the hippocampus in an experimental model of Multiple Sclerosis (MS).
Methods: In this experimental study, 35 male Wistar rats were randomly divided into five groups. Each group has 7 rats. These groups were included control, sham, model of MS and MS groups with plant extract treatments. In the experimental model of MS groups, induction of MS was carried out by single injection of ethidium bromide (EB) into the hippocampus. One week after MS induction by EB (0.01 %), the MS groups were treated by Ferula szowitsiana extract (5 and 10 μg/rat) for 3 consecutive days. Finally following the treatment period, for measuring spatial memory, Morris Water Maze test was carried out and the hippocampus of both sides were dissected and used for measurement of Malondialdehyde (MDA).
Results: The results showed that in the experimental model of MS group travelled distance (1022.44±53.29) and escape latency (41.30±3.29) increased compared to travelled distance (885.94±29.56) and escape latency (36.26±0.65) in the control group (p<0.001). Short-term treatment by Ferula szowitsiana extract in this models decreased the travelled distance (838.39±24.16) and escape latency (39.87±1.24) (P<0.001). MDA increased in the experimental model of MS group (3.8±0.51) compared to the control group (0.68±0.13) (p<0.001) and in the Ferula treated group (0.34±0.04) decreased compared to the MS animals (P<0.001).
Conclusion: Treatment with Ferula szowitsiana extract is able to prevent memory and learning reduction, through inhibition of lipid peroxidation in an experimental model of MS.
Mr Sajjad Saadat, Mehrdad Kalantari, Mohammad Bagher Kajbaf, Mozaffar Hosseininezhad,
Volume 27, Issue 4 (8-2019)
Abstract
Introdution: Multiple sclerosis is a chronic disease in the nervous system; It has many problems due to its chronic and promising nature. The treatment of this disease includes medical care and empowerment interventions for symptom management. The purpose of this study was to review the empowerment interventions in these patients.
Methods: This study was conducted in a Systematic Reviewperiod from January 2000 to June 2018. On indexing sites “Magiran, PubMed, Google Scholar and Science Direct” searched the key words of Multiple Sclerosis, Chronic Disease, Quality of Life, Self-care, Self-management, Rehabilitation, Empowerment, Psychotherapy, Psychological interventions, Clinical Trials, and Randomized Clinical Trial. Out of 1855 articles found, 33 articles were selected for review.
Results: The results of this study showed that empowerment interventions in people with MS can be divided into four categories of self-care, self-management, rehabilitation and psychotherapy interventions. Lack of attention to empowerment interventions in people with MS, especially in the Iran, low attention to male patients in implementing interventions, failure to consider the theoretical framework in the formulation of interventions, lack of follow-up test and non-use of virtual intervention methods (Such as using DVDs, consulting and telephone training, etc.) in Iranian studies, is one of the most respected points in previous studies.
Conclusion: Empowerment studies have provided significant results in reducing symptoms and improving the quality of life of patients, which can help improve these interventions by considering some of the points.
Fatemeh Zarei Mahmoud Abadi, Shayesteh Salehi, Mahsa Sadat Mousavi,
Volume 27, Issue 8 (12-2019)
Abstract
Introduction: The prevalence of sexual disorders is high among women with multiple sclerosis in the world. Sexual dysfunction is considered as one of the effective psychological factors on self-concept sexual function. The present study was conducted to evaluate the relation between sexual self-concept and sexual distress in women with multiple sclerosis.
Methods: The present descriptive correlational study was conducted on 115 married women with multiple sclerosis who were selected using convenient sampling method. Study population for the present study contained all the married women with multiple sclerosis who referred to ShahidSadoughi Hospital of Yazd in 2017. Data gathering tools were multi-dimensional sexual self-concept questionnaire and revised female sexual distress scale by DeRogatis. Achieved data were analyzed using independent t-test, Mann-Whitney, Kruskal-Wallis and Pearson and Spearman correlation coefficients.
Results: Results showed that the mean scores of positive, negative, situational sexual self-concept were respectively 94.62 ± 30.30, 29.57 ± 10.89, and 36.91 ± 12.58 and the mean score of sexual distress was 13.82 ± 13.18. Furthermore, a reverse significant relation existed between the positive sexual self-concept of the married women and their sexual distress (p < 0.05) and a direct significant relation existed between the negative sexual self-concept and sexual distress (p < 0.05); but no significant relation was found between situational sexual self-concept and sexual distress (p > 0.05).
Conclusion: Results of the present study showed that married women with multiple sclerosis who had a positive sexual self-concept would experience less sexual distress. Therefore, sexual self-concept could be a predictor of sexual distress in women.
Mojtaba Dehestani Ardakani,
Volume 28, Issue 8 (10-2020)
Abstract
Introduction: The purpose of this study was to determine the effect of aerobic exercise program on quality of life in multiple sclerosis men as a complementary therapeutic approach to multiple sclerosis.
Methods: This was a semi-experimental study. The statistical sample consisted of 60 people was selected by the available sampling method from Kahrizak Nursing Home where was also a member of the Iranian MS society. They were randomly divided into control and test groups. After an introductory session of the patients with the aims and intervention method in the experimental group, 27 sessions of 60 minutes of aerobic exercise program were performed in 9 weeks. Data collection tools consisted of a demographic questionnaire, a short quality of life (SF-8) questionnaire, and self-report checklist with a significant level of p≤0.05. Descriptive statistical tests, independent t-test and repeated measures analysis of variance were used for analysis using SPSS version 16 statistical software with a significance level of p≤0.05.
Results: The results showed that there was no significant different between the two groups in terms of the total score (df = 48 = T 21.1, p = 0.23) and dimensions of quality of life (Physical: df = 48, T = 1.31, p = 0.19; mental: df = 48, t = 0.96, p = 0.31) There was no significant difference between the control and experimental groups. The results of repeated measures analysis of variance showed that there was a significant difference between the experimental and control groups in terms of quality of life dimensions.
Conclusion: In general, aerobic exercise, which was chosen as an exercise program in this study, improves the quality of life of multiple sclerosis patients. Therefore, this complementary therapeutic approach is recommended as an effective and cost-effective method in cost and time, as well as the ability to learn and easy to administer to multiple sclerosis patients.
Yasaman Honarmandnasab, Mohammad Reza Kordi, Abbas Ali Gaeini,
Volume 28, Issue 12 (2-2021)
Abstract
Introduction: The aim of the present study was to investigate the effect of voluntary training period after the induction of experimental autoimmune encephalomyelitis (EAE) on some myelin-producing proteins in C57BL/6 female mice.
Methods: In this experimental study first 28 mice, which were 6-8 weeks old, were purchased and were randomly divided into three groups. Exercise activity (n=12), healthy control (n=8) and experimental autoimmune encephalomyelitis (EAE) control (n=8). Voluntary exercise group did exercises, 1 hour, 5 days a week for 4 weeks after induction of EAE and having the clinical score one for two days in a row. 48 hours after final exercise section, the mice were killed and immunohistochemistry was used to evaluate the expression of MBP and CNPase proteins. Using SPSS version 16 software, multiple analysis of variance and LSD post hoc test were used to examine the groups' data differences.
Results: The results showed that the expression of both proteins as a result of voluntary exercise had a significant increase in the exercise group compared to the EAE control group ( p<0.05).( in White Matter: MBP, Wheel Running and Control EAE, P= .017; Wheel Running and Healthy Control, P= .001; CNPase, Wheel Running and Control EAE, P= .015; Wheel Running and Healthy Control, P= .000; in Gray Matter: MBP, Wheel Running and Control EAE, P= .000; Wheel Running and Healthy Control, P= .000; CNPase, Wheel Running and Control EAE, P= .005; Wheel Running and Healthy Control, P= .001.
Conclusion: Voluntary exercise may have a positive effect on increasing myelination in treatment and control of MS.
Mozaffar Hosseininezhad, Sajjad Saadat, Houra Bakhshipour, Paria Nasiri,
Volume 29, Issue 1 (3-2021)
Abstract
Introduction: The aim of this study was to investigate the prevalence and incidence of multiple sclerosis (MS) in Guilan Province) and to compare the standardized prevalence by the factor of age in this province.
Methods: The study was a cross-sectional design that was conducted in 2018 at the Guilan MS Society (GMSS) on people with multiple sclerosis and examined the 654 people with multiple sclerosis case. In this study, the trend of MS disease was examined from 2009 to 2019 and in order to investigate the rate of cumulative incidence of the disease, new cases were defined based on the date of diagnosis of the disease from the beginning of 2018. Data collection was performed using a checklist that was collected during the GMSS registration by a registrar in the form of a structured interview. Prevalence rate was compared between different subgroups using Chi-Square and Fisher's exact tests. Field characteristics were described by using absolute and relative frequency indices or mean and standard deviation using Stata 13 and SPSS 19 statistical software.
Results: The results showed that 71.4% of all patients were female. The mean age of the patients was 36.5 years and the highest frequency of MS was observed in the age group of 30-40. The MS patients lived in the urban were 81%. The highest initial manifestations of people with multiple sclerosis were reported in numbness or tingling, vision problems, weakness, other symptoms, and walking (Gait) difficulties, respectively. The highest prevalence of MS was in Lahijan and then Rasht and Astaneh-ye Ashrafiyeh citie.
Conclusion: From the results of this study, it is concluded that there is no significant difference between the prevalence rate in Guilan Province and the standardized rate with the age adjustment based on the WHO standard population, although no analytical comparison has been performed in this study.
Sajjad Saadat, Mozaffar Hosseininezhad,
Volume 29, Issue 7 (10-2021)
Abstract
Introduction: The aim of this study was to compare eating behaviors in the patients with multiple sclerosis (MS) with recurrence of the disease in the past year and the control group.
Methods: This analytical cross-sectional study was a comparison that was performed in the statistical population of two groups of people with MS in Guilan Province in the second half of 2018. The first group consisted of people with MS with a recurrence of the disease in the past year and the second group of people with MS without a history of recurrence of the disease in the past year that were selected by matching the variables of age, sex and duration of the disease. In each of these groups, 104 people were employed as a sample in a targeted method from medical centers in Rasht. In order to collect data demographic information form and Dutch Eating Behaviour Questionnaire were used. Research data were analyzed by independent t-test using SPSS software version 16.
Results: The results showed that among patients with MS with a history of recurrence and the control group there was a significant difference (P <0.05) in the variables of emotional eating (t = 3.03, P = 0.01), external stimuli (t=4.49, P=0.01) and inhibition in eating (t =3.81, P=0.01).
Conclusion: Inappropriate eating behaviors are one of the factors associated with recurrence and disease attacks in people with MS. Therefore, it is suggested that psychologists and nutritionists consider the role of eating behaviors in these individuals to reduce disease attacks.
