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Showing 2 results for Inflammatory Cytokine

Moosa Javdani, Abolfazl Barzegar-Bafrouei,
Volume 28, Issue 5 (7-2020)
Abstract

Introduction: Various lesions trigger an inflammatory response in the host body. These injuries include surgical stress Surgery exerts stress on the body. Systemic inflammatory syndrome is a reflection of the degree of surgical stress and as a system of assessing the severity of postoperative stress. Regular complexes of inflammatory polypeptide molecules contribute to the development of this inflammatory response known as cytokines. Lack of local control over the release of these cytokines can cause systemic inflammation, and potentially devastating complications.
In writing this review articles, articles indexed in the following databases were used: Science Direct, Scopus, Springer Science, PubMed and Google Scholar Ninety two related research papers, including quantitative and qualitative researches in English, related to the last 40 years (1979- 2019) were included in this study. The current review article has been written based on 92 articles and the keywords of “Surgical Stress, Systemic Inflammatory Response Syndrome, Pro-Inflammatory Cytokines, and Anti-Inflammatory Cytokines”.
Studies in humans and animal models suggest that both types of pro-inflammatory and anti-inflammatory cytokines following diverse primary stimuli, including endotoxin release, complement system activation, ischemia-perfusion injury, and other ways.
Conclusion: Inflammatory and anti-inflammatory cytokines are the result of a complex unpredictable interaction of immune system effects on the body and even multiple effects on body organs. New therapeutic strategies for the absorption of cytokines are a powerful way to enhance and improve proper output, following systemic inflammatory response syndrome.

Zahra Shamsi, Abdolhossein Taheri Kalani, Mahmoud Nikseresht, Somayeh Bakhtiari Dehbalaei, Leyla Shamsi,
Volume 32, Issue 11 (2-2025)
Abstract

Introduction: In Parkinson's disease, the balance between Pro-inflammatory and anti-inflammatory cytokines is disturbed, causing chronic neuroinflammation. The aim of present study was to compare the effects of continuous and interval aerobic training on the expression of interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α) in cerebellum of Parkinson's model rats.
Methods: In this experimental study, 28 adult male Wistar rats (weighting 180-250 gr) were randomly divided into four groups (n=7 each): control, Parkinson, Parkinson+ continuous training, and Parkinson+ interval training. Rotenone was utilized to induce Parkinson's in rats. The continuous training lasted between 15 to 40 minutes, while the interval training consisted of two to six sets of running on the treadmill at a speed of 10- 20 meters per minute for six weeks and five sessions per week. At the end of the intervention, the levels of IL-1 and TNF-α in the cerebellum tissue were assessed by Bradford method. The data were analyzed using one-way analysis of variance (ANOVA), followed by post hoc LSD test, utilizing SPSS version 16 software, with a significant level set at P<0.05.
Results: The levels of IL-1 and TNF-α in the cerebellar tissue of the control group were significantly lower (P=0.0001) compared to the other groups, and in the Parkinson's group, they were significantly higher than the Parkinson's+ continuous training and Parkinson's+ interval training groups (both; P=0.0001). There was no significant difference in IL-1 levels between the two training groups (P=0.062); nontheless, interval training significantly reduced the level of TNF-α compared to continuous training (P=0.007).
Conclusion: Based on these findings, interval aerobic training is a more efficient method in modulating pro-inflammatory cytokines in the cerebellum of Parkinson's model rats compared to continuous training, which can slow down the progression of the disease.
 


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