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Showing 4 results for Hiit

Abbas Foroughi Pordanjani , Mohsen Salesi, Rasoul Rezaei, Javad Nemati,
Volume 30, Issue 10 (1-2023)
Abstract

Introduction: Inflammation in the brain is known as neuroinflammation and increases TNF-α (Tumor necrosis factor alpha) secretion and activates the TLR4 (Toll-like receptor 4) pathway. The aim of this study was to evaluate the effect of 4 weeks preconditioning with high intensity intermittent training (HIIT) and moderate intensity training (MICT) on TNF-α and TLR4 levels in male Wistar rats.
Methods: The current research was an experimental study.18 male Wistar rats were divided into three groups: high intensity intermittent training (6 heads), continuous moderate intensity training (6 heads) and the control group (6 heads). HIIT program included 6 stages of 2-minute activity with intensity of 85-90% VO2max and 5 stages of active rest for 2 minutes and MICT program with intensity of 65% VO2max with the same duration as HIIT for 4 weeks and 5 days per week was implemented. 48 hours after the last training session, rats were dissected and cortical tissues and layers of mice were extracted for TNF-α and TLR-4 using western blotting. Data analysis was performed using ANOVA test at a significance level of 0.05 With the help of SPSS version 16 software.
Results: The results of the present study showed that TNF-α and TLR4 in the cortex and stratum cerebral areas after 4 weeks of high-intensity and moderate-intensity intermittent aerobic exercise did not change significantly compared to the control group (p≥0.05).
Conclusion: According to these findings, it can be stated that exercise with high or moderate intensity cannot be an effective factor in increasing inflammatory markers in the brain.
 

Mohammad Ranaei, Ali Yaghoubi, Sadegh Cheragh-Birjandi,
Volume 31, Issue 3 (6-2023)
Abstract

Introduction: The aim of this study was to investigate the effect of eight weeks of high-intensity interval training (HIIT) and Portulaca Oleracea extract on FGF-21 levels and insulin resistance in rats with NAFLD.
Methods: Twenty male Wistar rats at six weeks old and 160 to 185 g weight were randomly divided into four groups: fatty liver control, HIIT, Portulaca Oleracea extract, and HIIT+Portulaca Oleracea extract. According to the weight of the mice, Portulaca Oleracea supplement with a dose of 400 mg/kg was given to the two respective groups. The HIIT training protocol was performed for 8 weeks, 5 sessions per week, and each session was performed at 80-90% of maximum speed. Hepatic FGF21 level and insulin resistance were measured after 8 weeks of HIIT training and consumption of purslane extract. One-way analysis of variance and Tukey's post hoc test were used to compare groups at a significance level of p<0.05.
Results: Insulin resistance in HIIT (P=0.005), Portulaca Oleracea extract (P=0.011), and HIIT+Portulaca Oleracea extract (P=0.002) groups were significantly lower than fatty liver control group. The level of liver FGF-21 in the HIIT (p=0.023), Portulaca Oleracea extract (p=0.005) and HIIT+ Portulaca Oleracea extract (p=0.001) groups was significantly higher than the fatty liver control group.
Conclusion: It seems that HIIT and Portulaca Oleracea extract could improve insulin resistance in NAFLD by increasing FGF-21 levels and can play an important role in controlling the progress of this disease.
 

Mina Bahrami, Amir Hossein Haghighi, Majid Asadi-Shekaari, Hadi Shahrabadi, Ahad Shafiei,
Volume 31, Issue 10 (1-2024)
Abstract

Introduction: The use of methamphetamine (METH) can cause neurotoxicity. The purpose of this research was to investigate the effect of high intensity interval training on tissue changes and gene expression of neurodegeneration indicators in the hippocampal tissue of methamphetamine-dependent rats.
Methods: In this experimental research, 32 male rats were divided into four equal groups of saline, primary methamphetamine (METH-1), methamphetamine+training (METH+HIT) and secondary methamphetamine (METH-2). METH was injected at the dose of 5 mg/kg body weight for 21 days. The exercise program (5 sessions per week) included interval training (4 sets of 2 minutes with high intensity and 2 to 4 minutes of active rest between sets) on a treadmill. At the end of the injection and training period, the hippocampus tissue of the rats was extracted to evaluate the pathological changes and gene expression of related indicators. Data were analyzed using one-way ANOVA test at the significance level of (P≥0.05) by GraphPad software.
Results: The results of gene expression in the hippocampal tissue showed that along with METH injection, the expression of α-syn, GSK-3β, CDK5, APP, Tau and p-Tau indicators increased significantly;  nevertheless the exercises (HIT) decreased the expression of the genes of the current research. Pathological studies showed that METH injection caused a significant increase in the destruction of neurons in the CA1 region of the hippocampus, and performing intense intermittent exercise had significantly reduced the destruction of neurons.
Conclusion: Methamphetamine has caused intoxication and neurodegeneration, and HIT training has been able to improve these conditions to some extent. More research is needed in this field to reach general conclusions.
 

Sam Rahmani Chegani, Mehdi Roozbahani, Seyed Ali Hosseini, Ahmad Hemat Far, Masoud Moeini,
Volume 32, Issue 12 (3-2025)
Abstract

Introduction: The present study investigated the effectiveness of high-intensity interval training (HIIT) and pollen (PO) on tyrosine kinase receptor B (TRKb) in mice exposed to cadmium. Studies have shown that cadmium causes a decrease in BDNF and inactivation of TRKb.
Methods: 25 male Sprague-Dawley mice were selected at the age of 8 weeks, and were randomly replaced in five groups of five, which included the healthy control group (HC), the cadmium control group CD), cadmium + pollen group (PO), cadmium group + intense intermittent exercise (HIIT), cadmium + pollen group + intense intermittent exercise (HIIT-PO) group. Cadmium was administered as cadmium chloride 400 mg/kg.l dissolved in water to all groups except the healthy control. Daily, 200 mg of flower pollen in 2.4 cc of normal saline was given by gavage to groups (PO/HIIT-PO). To determine the maximum intensity of exercise, the standard Bedford incremental test was used for the HIIT-PO and HIIT groups. 48 hours after the final training session and supplementation, the mice were anesthetized using ketamine (50 mg/kg) and xylosine (20 mg/kg) after a 12-hour fasting period. The hippocampus of the brain was extracted and the data were analyzed using independent T-test and two-way ANOVA with SPSS 16 software.
Results: Cadmium significantly decreased TRKb (P≤0.05), HIIT training and pollen supplementation significantly increased TRKb, and the interaction effect of HIIT training and pollen supplementation was also significant (P≤0.05).
Conclusion: It is possible that the antioxidant effects of pollen can increase TRKb levels, HIIT training increases the concentration of hydrogen peroxide (H2O2) and tumor necrosis factor alpha (TNF-α) in the brain, which can facilitate the synthesis of BDNF and therefore increase TRKb levels.
 


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