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Showing 3 results for Encapsulation
Design and Preparation of Encapsulated Nano-Liposome Controlled Release including Silibinin Anti-Cancer Herbal Drug (Nano Phytosome)
Mm Ochi Ardebili, Gh Amoabediny, Sm Rezayat, A Akbarzadeh, B Ebrahimi,
Volume 23, Issue 3 (6-2015)
Abstract
Introduction: Nano-liposomes are Nano particulate vesicles with lipoid membrane which are under extensive investigation as drug carriers for improving the delivery of therapeutic agents. This study intended to enhance efficacy of Silibinin herbal drug in Nano liposome system (Nano phytosome) via encapsulation for delivery to liver cancer cells. Silibinin is one of the anti-cancer drugs, which its antitumor efficacy is primarily attributed to decreasing N-nitrosodiethylamine in hepatocit carcinoma cells. Nano Liposome encapsulation of Silibinin can dramatically improve its biological activity and increase stability of Silibinin in blood. Methods: Small uni-lamellar (SUV) vesicles entrapping Silibinin were prepared using DiPalmitoyl PhosphatidylCholine (DPPC), cholesterol: DSPE-MPEG2000 at 7:4:0.36 molar ratio , the fluorescent label (DIL) incorporated in the lipid bilayer at 0.09 mol % as lipophilic phase and buffer of HEPES as hydrophilic phase. Moreover, Nano Liposome size, Zeta-potential, encapsulation efficiency and release of drug were determined after Nano Liposome production . Results: The study results demonstrated that mean nano-liposome diameter was 46.3 nm. The size and structure of Nano-liposomes were analyzed by SEM and TEM images. The zeta potential of the encapsulated Nano-liposomes was shown -23.25. The encapsulation efficiency for Silibinin was about 24.37%. Conclusion: In this study, silibinin drug encapsulated nano-liposome controlled release system to improve the solubility and bioavailability of silibinin for delivery to liver cancer cells.
Strategy of Improvements in the rapeutic index of medicinal herbs of Iranianin digenous: Synthesis and characterization of phospholipid lipid-based vesicles in corporated Trachyspermum copticum
F Haghiralsadat , M Azhdari , Sm Kalantar , S Naderinezhad , K Teymourizadeh , M Yazdani , M Hashemi , F Daneshmand ,
Volume 24, Issue 6 (9-2016)
Abstract

Introduction: Medicinal herbs are one of the most valuable Iranian National assets. Herbal essential oils have valuable therapeutic properties. Oxidation and volatile of essential oils caused some limitations in its usage. Nanoliposomes are nonometric lipid-based vesicles. Drug delivery carrier to improve delivery of therapeutic agent is one of the most well-known application of liposomal vesicles. In recent years, scientists paid much attention to encapsulate plant essential oil in nanocarriers. The goal of presented study was encapsulation of Trachyspermumcopticum in nanoliposomal carriers to improve the therapeutic functionality.

Methods: The essential oil of Trachyspermumcopticum was extracted by Clevenger instrument using hydrodistilation method and its components were determined with gas-mass chromatography. Small unilamellar lipid based vesicles containing Trachyspermumcopticum essential oil were prepared using thin film hydration method. Lipid phase were contained SPC 80, cholesterol and Trachyspermumcopticum essential oil. Nano-vesicles were evaluated by several analyses such as encapsulation efficiency, size, zeta potential, release kinetic profile and surface morphology.

Results: Results showed that the encapsulation efficiency of entrapped essential oil was 35.6±7.4% and mean nano-liposome diameter was 186.1 nm. The prepared nano-vesicle led to controlled release profile.

Conclusion: In the present study, encapsulation of Trachyspermumcopticum essential oil into nano liposome was performed in order increasing stability, water- solubility and improving therapeutic index. The prepared formulation was slow-release, well-coating to preserve the essential oil against oxidation and increasing stability.


Challenges of Probiotics Microencapsulation by Spray Drying Method
Neda Hajipour, Amir Mohammad Mortazavian, Aziz Homayouni Rad,
Volume 28, Issue 4 (6-2020)
Abstract
Introduction: In the recent years, attention to the use of probiotic drugs and probiotic food products, due to probiotic’s functional and health properties has been increased. The storage and the viability of the probiotics in the products and passing through the gastrointestinal tract was always a big challenge. Drying is one of the functional and important choices that can be used for stabilizing microbial species and makes the bacterial usage easy. Among different microencapsulation methods, spray drying is one of the important drying methods that can be used in industrial scale and size. Optimizing the effective parameters on the cultivation and separation of probiotic bacteria, the most important and challenging parameters of spray drying that have influence on probiotic products, and choose of the best wall materials for the cores, are the most important and challenging factors that are necessary for optimizing the microencapsulation in industrial scale. In this review article, the factors affecting the survival and resistance of bacteria in the stage before entering the spray dryer and the factors affecting the survival of probiotic bacteria during the drying stage are discussed. In addition, the important criteria for selecting microfiber wall materials and the tests that are often performed on probiotic microfiber resulting from spray drying have been examined.
 
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