Showing 3 results for Dexamethasone
A Mirvakili, Mb Owlia, S Atighechi, S Allaf-Akbari,
Volume 16, Issue 4 (1-2009)
Abstract
Introduction: There are controversies regarding treatment of peritonsillar abscess as a common infection of head and neck, especially for prescription of corticosteroids. According to review of articles, use of corticosteroids in management of this abscess is increasing, but more controlled and comparative studies are needed. In this clinical trial study, we evaluated corticosteroid as an adjutant therapy for peritonsillar abscess.
Methods: This clinical trial study was done on 50 hospitalized patients divided into 2 groups steroid and placebo. Antibiotic therapy and method of abscess drainage was the same in both groups. A special questionnaire included characteristics, symptoms, clinical course and complications of patients. Data was filled and analyzed by SPSS software using chi square, repeated measurement and t tests.
Results: Normalization of body temperature within 12 hours after treatment and mean time of painless swallowing was 100% and 9 hours in the steroid group as compared to 84% and 15 hours in placebo group (p value=0.04). Trismus recovery was faster in steroid group. Hospitalization period was 3 and 4 days in steroid and placebo groups, respectively (P value>0.05). Fewer complications were reported in steroid receiving patients. There was one case of relapse in the steroid group and 5 cases in the placebo group (P value=0.09).
Conclusion: According to our findings, it seems that corticosteroid adjuvant therapy of peritonsillar abscess is effective and doesn’t lead to any important complication
L Hajivandi, S Montazeri, M Irvani, A Oliyai, Mh Haghighi Zade,
Volume 21, Issue 5 (12-2013)
Abstract
Introduction: One of the problems in midwifery is labor induction in the cases which the termination of pregnancy is necessary. Thus, the methods for cervical ripening and labor induction have always been taken into consideration. The aim of this study was to determine the effect of intramuscular dexamethasone on onset of labor in postdate pregnancy.
Methods: This single-blind, randomized clinical trial study was performed on 100 nulliparous women who referred to Amir Al Momenin hospital in Ahvaz. The patients were randomly divided into two groups. Single dose of intramuscular dexamethasone (8 mg) was administered to the study group 12 h before induction. The controls were given 2 cc of normal saline at the same interval.
Results: There was no significant difference between the two groups in terms of age, demographic characteristics, initial Bishop score, first and fifth minute Apgar score, and meconium. After the injection, Bishop score in the study group was 7/23 ± 1/32 and in the control group, it was 2/98 ± 0/89. Thus, the difference was significant (P<0.0001). The mean interval between induction with the onset of the active phase was 3/1±0.68 hours in the study group, whereas in the control group 4/2±1/3 hours was observed (P=0.001).
Conclusion: The results of this study showed that intramuscular dexamethasone by improving Bishop score causes the onset of labor pains resulting in decrease of labor duration in postdate pregnancies.
Malek Soleimani Mehranjani, Seyyedeh Masomeh Mohammadi,
Volume 27, Issue 1 (5-2019)
Abstract
Introdution: Dexamethasone is used in inflammatory disease, leukemia and nausea, which increases the oxygen free radicals in the testis as a consequence. The aim of this study was to study the protective effect of Quercetin as a plant flavonoid and strong antioxidant on testis histological changes and Spermatogenesis indexes in adult mice following treatment with Dexamethasone.
Methods: 24 adult male mice (NMRI) were divided into 4 groups (n=6): control, Dexamethasone (7mg/kg/day), Quercetin (50mg/kg/day) and Dexamethasone + Quercetin. 7 days after intra peritoneal treatment, the right testis were removed, fixed, sectioned, processed and stained with Heidenhain’s Azan method, testis histological changes and spermatogenesis indexes were studied by stereological techniques. Data were analyzed using one-way ANOVA and the means were considered significantly different (P<0.05).
Results: A significant decrease was considered in the mean volume and diameter of the seminiferous tubules, germinal epithelium height, spermatogenesis indexes, the number of spermatocytes, long spermatids, round spermatid and Leydig cells, and also a significant increase in the volume of interstitial tissue were found in the Dexamethasone group compared to the control (P<0.001). The mentioned parameters in the Dexamethasone + Quercetin group were compensated to the control level (P>0.05).
Conclusion: Our results indicated that Quercetin as a strong antioxidant can reduce the destructive effects of dexamethasone on the histology of testis tissue and Spermatogenesis indexes in mice. Therefore, Quercetin is suggested as a therapeutic supplement in regimens containing Dexamethasone
