Showing 11 results for Anemia
Mr Shahbani, K Barkhordari, Mh Ahmadieh,
Volume 12, Issue 1 (4-2004)
Abstract
Introduction: It is a fact that iron deficiency anemia in infants leads to unpleasant effects on Growth , Cognition and Psyche for life . During the late seventies,relation of iron deficiency anaemia(I.D.A) and permanent complications was suggested , and later on, several studies proved that handicaps occur when iron deficiency (I.D) is severe enough to develope I.D.A
Method & Materials : In our study, we evaluated the prevalence of I.D.A and I.D in children aged between 6&60 months in Yazd . In this cross - sectional study, 449 cases were selected by clustering 239 boys and 210 girls. Hemoglobin( Hb) and ferritin was measured .5 cases were omitted from the study. Data was analyzed using SPSS computer software program.
Results : In our study, prevalence of Iron deficiency anemia was 3.8% and that of Iron deficiency was 8.6%. Prevalence of other anemias in the population under study was 8.4% . 79.2% of children in this group were not anemic and considered as normal . Iron deficiency was twice that of Iron deficiency anemia. (p value< 0.05 ).
Conclusion : The total prevalance of anemia in this study was 20.8% with Iron deficency anemia 3-4% and Iron deficiency 8.6% . The prevalence of iron deficiency and other forms of anemia in this study was less than many other parts of the world, except USA . Anemia in children aged 6-17 months was more than other age groups. Also, anemia in girls was more prevalent than boys .
A Fakhre- Movahedi , F Ahadi ,
Volume 12, Issue 4 (1-2005)
Abstract
Introduction: The purpose of this cross sectional study was to determine the prevalence of iron deficiency anemia among high school girls in Semnan city, 2002. Materials and Methods: In this study, 402 students were selected from among 4900 students at fourteen high schools in Semnan city by simple random sampling method. Study was performed in two stages initially, blood test for determination of hemoglobin was performed for all of the 402 students and later, after primary analysis, those students that were anemic (Hb< 12 g/dL) were selected for the second stage of study wherein their serum iron, total iron bonding capacity and ferritin levels were measured. Iron deficiency anemia was defined as serum ferritin less than 15 ng/L, and or transferin saturation percent less than 16%. Results: The results showed that 38 students (9.5%) were anemic that 4.5% (18 students) had iron deficiency anemia. Also, there was no significant relationship between iron deficiency anemia and student's age, age of menarche and sports activities. Conclusion: As there was no significant relationship between iron deficiency anemia and student's age, age of menarche and sports activities, further investigations are needed for determining other etiologic factors of iron deficiency anemia among high school girls in Semnan city
M Rahimian, A Hasan Zadeh, R Sami,
Volume 13, Issue 1 (4-2005)
Abstract
Introdaction: The purpose of this study was to evaluate the therapeutic and side effects of erythropoietin in the management of anemia in chronic renal failure. In this study, 60 patients were given Erythropoietin subcutaneously three times/week for 2 months.
Methods: Mean hemoglobin of patients was recorded before beginning Erythropoietin and also one weeks, one month and two months after treatment.
Results: Mean hemoglobin value before treatment was 7.6 g/dl that increased to 9.08g/dl 2 months later. Hemoglobin levels were not dependent on the age and sex of the patient, but there was a meaningful difference between diabetics and nondiabetics.
Conclusion: The side effects of Erythropoietin in this study in order of frequency were as follows: Hypertension, A.V fistula thrombosis, allergy and seizure.
Mr Mortazavizadeh, F Binesh, A Bahrami- Ahmadi,
Volume 13, Issue 5 (1-2006)
Abstract
Thiamine responsive megaloblastic anemia (TRMA), also known as Roger syndrome is an autosomal recessive disorder resulting from the deficiency of thiamine (Vitamin B1) transporter protein. This is the report of a 3- year follow up of a female child who presented in 2000 at the age of 11 with severe anemia, congenital deafness and diabetes mellitus.
In our follow-up period we prescribed 100-mg thiamine tablet daily and after that there was a rise in her hemoglobin level to normal. Her hyperglycemia was controlled during the early phase of treatment. It recurred several months after start of treatment, but needed lower doses of insulin for control. Hearing loss did not respond to thiamine. Presently, the patient is apparently in good condition with normal hemoglobin level.
F Najafi, N Taheri,
Volume 14, Issue 3 (10-2006)
Abstract
Introduction: Chronic renal disease (C.R.D) is a pathophysiological process due to progressive and irreversible decrease in number and function of nephrons in the kidney. Anemia is one of the most important complications in CRD patients. Anemia is caused mainly due to diminished production of erythropoietin (EPO), which is treated by weekly injection of the EPO. L-carnitine added to EPO can increase the efficacy of EPO.
Methods: Present study, from March 2003 until September 2004 (18 months), evaluates the effects of L-carnitine added to EPO in 30 patients at Shaheed Rahnemon hemodialysis center of Yazd. Each patient was administered one oral table (250 mg) of L-carnitine, twice a day along with EPO for 90 days. EPO was in the form of injection 2000 iu/sc after dialysis.(three times per week). One questionnaire was completed for each patient, which included demographic characteristics, type of disease, duration of the hemodialysis, Hb and Hct levels, transferrin saturation and ferritin levels. Hb ,Hct and transferrin saturations were measured on days 1, 45 and 90. Results were analyzed by paired t test and analysis of variance.
Results: Results of this study showed that the mean Hb levels and Hct were significantly raised up to
1.1 mg/dl (P.value<0.001) and 2.7% (P.Value<0.001), respectively. In addition, significant decrease of 5.75% in transferrin (P.Value< 0.001) and 121ng/ml in ferritin levels (P.Value< 0.001) was observed. Efficacy of EPO plus L-carnitine was affected only by duration of hemodialysis and not by age, sex or causes of CRD.
Conclusion: L-carnitine added to EPO increases the efficacy of EPO after 3 months.
R Fallah, M Mortazavi Zadeh, F Binesh,
Volume 14, Issue 4 (1-2007)
Abstract
Mitochondrial myopathy, lactic acidosis, and siderobastic anemia (MLA SA) syndrome is one of the newly reported mitochondrial diseases, seven cases of which have been reported. We report a child with inflammatory myopathy, sideroblastic anemia and lactic acidosis .The patient is a 8.5 year old boy with normal cognitive function suffering from chronic progressive weakness in lower extremities, inability to walk since four months and pallor. In paraclinical evaluation, sideroblastic anemia, mild lactic acidosis and elevated muscle enzymes were seen. Inflammatory myopathy (myositis) in muscle biopsy was detected as well .The patient was administered oral prednisolone, folic acid, B6 and underwent regular physiotherapy. He ambulated after four months and resumed education and schooling.
M Albockordi, A Mahmoudian, R Eshaghi, Z Farajzadegan,
Volume 16, Issue 1 (4-2008)
Abstract
Introduction: Iron deficiency anemia (IDA) is the most common form of anemia and one of the most important health problems. Iron supplementation for high risk groups can prevent IDA and its complications in the community. We need to have a holistic approach to control IDA with minimum cost and complications. Considering the high prevalence rate of IDA in Iran, assessment of the effects of micronutrients in the treatment of IDA is essential. The current study was designed to study the complete iron therapy program in Iran and evaluate the effect of simultaneous administration of vitamin A and C on hemoglobin (Hb) levels.
Methods: A triple blind randomized clinical trial was conducted in secondary schools for girls in Shahinshahr city of Iran. 120 students were selected after initial screening for clinical presentation of anemia. They were assigned to three groups. All the cases were administered 50mg elemental iron, 0.5mg folic acid and 11mg elemental zinc. However, group A received placebo, group B received 250mg vitamin C and placebo of vitamin A and group C received 250mg vitamin C and 100000 IU vitamin A. The hemoglobin levels were measured on day one and eight weeks later. Data was analyzed using software SPSS version 11.5 and statistical test used was one way ANOVA test.
Results: There were statistical significant differences between the final Hemoglobin levels of the three groups (P<0.001). Hb increase in group C was significantly higher as compared to the control group (P<0.012). There was a difference between the Hb levels of group B and C, but this difference was not significant.
Conclusion: The findings showed that simultaneous supplementation of iron, folic acid and zinc with vitamin A and C is very effective for increasing hemoglobin levels. Further investigations are needed to confirm this hypothesis for treatment of IDA.
F Mohseni Moghadam, B Shidi-Zandi , A Khodadadi-Zadeh, Z Sharif Zadeh Yazdi ,
Volume 16, Issue 4 (1-2009)
Abstract
Introduction: Glycemia and blood glucose levels are under the effect of Hb A1c and therefore they could be considered as a valid index for the follow-up and control of diabetes .There are different and controversial reports on the effects of iron deficiency anemia on Hb A1c. Effects of IDA in non diabetic patients are also unknown. The aim of the study was the comparison of Hb A1C levels in healthy patients and non diabetic Iron deficiency anemia (IDA) patients before and after intervention in Rafsanjan.
Methods: This research was a semi– experimental intervention study. The population under study consisted of 30 non diabetic IDA patients and 30 healthy patients in Rafsanjan that were matched for age and sex and other characteristics. Ferritin, Hb, HCT, MCV, MCH, MCHC, FBS, BS 2HPP and Hb A1c, were measured to confirm IDA. These parameters were also measured in the healthy subjects (control group) to confirm their health and them being non diabetic and iron sufficient and all parameters were compared after the intervention. Then all patients with IDA were treated with iron 6mg/ kg for 3 months. The tests was repeated again and results compared with the results of both the groups before the intervention.
Results: The mean Hb A1c level before iron treatment was (7.64±2.08) in patients with IDA that was higher than the control group (5.97± 1.01)(p<0.05). Hb A1c decreased after iron therapy in patients with IDA.
Conclusion: It is recommended that before any diagnostic or therapeutic decisions are made with regards to Hb A1c, iron deficiency should be corrected.
A Hashemi, Ah Jafari, M Kheirandish, Kh Dehghani, F Nourani, F Motavaselian,
Volume 16, Issue 5 (1-2009)
Abstract
Thiamine Responsive megaloblastic anemia in DIDMOA (Wolfram) syndrome has an autosomal- recessive mode of inheritance . Megaloblastic anemia and sideroblastic anemia is accompanied by diabetes insipidus (DI), diabetes mellitus (DM) ,optic atrophy (OA) and deafness (D). Neutropenia and thrombocytopenia are also present.
We report a 7 month old girl with congenital macrocytic anemia a rare clinical feature of Wolfram,s syndrome with increased plasma levels of blood glucose, both of which dramatically responded to administration of thiamine in large doses .
The patient also had neurosensorial deafness, but no improvement was observed in the deafness. We presented the case because thiamine-responsive megaloblastic anemia is a rare clinical presentation of Wolfram syndrome and after institution of treatment with thiamine, the anemia and hyperglycemia returned to normal.
H Mozaffari-Khosravi, M Noori Shadkam, Y Naghiaee,
Volume 17, Issue 3 (7-2009)
Abstract
Introduction: It is generally assumed that 50% of the cases of anemia are due to iron deficiency. The most severe consequence of iron depletion is iron deficiency anemia (IDA), and it is still considered the most common nutrition deficiency worldwide. The main risk factors for IDA include: inadequate iron intake, impaired absorption or transport, physiologic losses associated with chronological or reproductive age, or acute or chronic blood loss, parasite infections such as hookworms, acute and chronic infections, including malaria, cancer, tuberculosis, HIV and other micronutrient deficiencies, including vitamins A and B12, folate, riboflavin, and copper deficiency.
Methods: This work as a cross-sectional study was done in 2007-2008 in Yazd. Two hundred girls who participated in the study were selected randomly from eight girl high schools. Five ml venous blood was collected for determination of serum ferritin and cell blood count (CBC). Serum ferritin was determined by using ECLIA method and CBC by cell counter SYSMEX KX21N. Iron deficiency was defined as having serum ferritin values below 12 μ/l. Anemia was defined as having Hemoglobin levels below12 g/dl. Iron-deficiency anemia was considered to be the combination of both.
Results: The3 mean age)years) and body mass index (kg/m2) were 15.19±0.7years and 21.5±4.2, respectively. Distribution in the 14, 15 and 16 years and more age groups were 13, 58.5 and 28.5 percent, respectively. Mean of Hemoglobin(g/dl), Hematocrit(%), MCV (fl), MCH (pg), MCHC (g/dl) and ferritin(μ/l) were 12.8±0.9, 38.9±3.0, 80.7±4.3, 26.6±1.8, 33.2±3.6 and 23±18.2, respectively. Of the total, 13.5% were anemic, 68% of which had Iron Deficiency Anemia (9.3% of the total). Iron deficiency was present in 34.7% of the population under study.
Conclusion: According to world health organization criteria, anemia is a mild public health problem in this region, but iron deficiency is a significant problem and suitable measures for control and prevention of it should be undertaken.
Fatemeh Mojallal Najar, Mohammad Reza Kazemi, Ali Raee Ezzabadi,
Volume 29, Issue 6 (9-2021)
Abstract
Introduction: Sickle cell anemia (SCA) is generally diagnosed in the early childhood and the disease is usually diagnosed in the first years of life by its clinical manifestations. The crises of this disease worsens during pregnancy. In this report, a 24-year-old pregnant woman with gestational age of 29 weeks and six days, G2P2A0L1, is presented. She complained of severe back and lower extremity pain. Considering the refractory pain, severe anemia, and absence of delivery process signs, further tests detected SCA for her. Preterm termination of pregnancy were performed by cesarean section regarding severe non-controlled pain, severe IUGR (intrauterine growth retardation), severe oligohydramnios, and previous caesarian section. A female baby was born with Apgar score of 8 and a birth weight of 1250 grams. Considering the high probability of vascular occlusion crisis and severe anemia associated with SCA during pregnancy, it is reasonable to seek sickle cells in all the pregnant patients with severe unexplained anemia or pain.
