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Showing 3 results for Amniotic Fluid
Comparative Study of Pregnancy Outcome in Premature Rupture of Membranes With Amniotic Fluid Indices of less and more than 5
F Tavassoli, M Ghasemi, A Mohammad Zadeh , J Sharifian , S Tavasooli,
Volume 17, Issue 5 (3-2010)
Abstract
Introduction: Preterm premature rupture of the membranes (PPROM) is one of the most important causes of perinatal morbidity and mortality. The aim of this study was to evaluate pregnancy outcome in preterm premature rupture of the membranes with amniotic fluid index less than 5 and more than 5. Methods: This prospective study was performed on 137 pregnant women with gestational age of 28-34 weeks with PPROM from Oct 2006 to Oct 2008. The patients were divided in two groups according to amniotic fluid index: AFI<5 (77 cases), AFI≥5 (60 cases). Chi-square test was used for qualitative variables, while T-student test was used for quantitative test. Results: Both groups were similar with respect to number of pregnancies, gestational age at rupture of the membranes and birth weight. In the group with AFI<5, applied latency was significantly shorter (PV=0.049), rate of cesarean section was higher due to fetal distress (PV=0.008), neonatal Apgar score in first minute was lower during the first week (PV=0.0127) and the rate of neonatal death was higher (PV=0.045) during the first week. Conclusion: An AFI<5 cm after PPROM is associated with earlier delivery, higher rate of cesarean due to fetal distress, higher rate of neonatal death, and lower neonatal Apgar score in first minute during the first week
Effect of Orally Administered Morphine on the Development of Amniotic and Chorionic Cavities in Pregnant Wistar Rats
M Kazemi, H Sahraei, M Azarnia, H Bahadoran,
Volume 18, Issue 5 (12-2010)
Abstract
Introduction: Previous studies indicate that morphine consumption during pregnancy can inhibit embryonic development. The present study evaluated the effects of orally administered morphine on the development of embryonic cavities in nine day pregnant rats. Methods: Female Wistar rats weighing between 170-200 grams were used in the present study. Experimental group received morphine (0.05 mg/ml of tap water) after one night coupling with male rats for mating. On the 9th day of pregnancy, the pregnant animals were anesthetized with chloroform and the embryos were removed surgically and fixed in 10% formalin for a week. The fixed embryos were processed and stained by H & E method and evaluated. The surface areas of amniotic and chorionic cavities and the whole body surface area of embryos were calculated using MOTIC software. Results: Findings indicated that both chorionic cavity and whole body surface areas of embryos were increased in the experimental group. In addition, surface area of amniotic cavity was reduced in experimental group. Conclusion: This study showed that oral morphine consumption caused a significant decrease in the embryonic amniotic cavity and furthermore, delay in natural embryonic amniotic cavity development can result in abnormal function and growth defect of the kidneys of infants of mothers addicted to morphine.
Human Amniotic Fluid Stem Cells: General Characteristics and Potential Therapeutic Applications
Seyed Mehdi Hoseini, Maryam Moghaddam-Matin, Ahmad Reza Bahrami, Fateme Montazeri, Seyed Mehdi Kalantar,
Volume 28, Issue 12 (2-2021)
Abstract
Introduction: Amniotic fluid contains a mixture of different cell types sloughed from the fetal skin, respiratory, alimentary and urogenital tracts, as well as the amnion membrane. As amniotic fluid develops prior to the process of gastrulation, many cells found in its heterogeneous population do not undergo lineage specialization. Therefore, amniotic fluid-derived mesenchymal stem cells (AF-MSCs) may correspond to a new class of stem cells with properties of intermediate plasticity between pluripotent and adult stem cell types. Compared to mesenchymal stem cells (MSCs) from other sources, such as bone marrow, AF-MSCs have better properties for clinical applications, such as differentiation into the cells of three germ layers, high clonal capacity, ability to form embryoid bodies, expression of pluripotent markers, high self-renewal capacity (over 250 population doublings) with normal karyotype at late passages, long telomere length due to continued telomerase activity, specially non-tumorigenicity, low immunogenicity, anti-inflammatory and immunomodulatory properties.
Conclusion: Such features have nominated AF-MSC for a range of clinical applications, including in regenerative medicine. In several studies, these cells have been used to regenerate nerve, lung, and heart tissues. Overall, AF-MSCs are expected to be an ideal source of stem cells for future regenerative medicine and tissue engineering.

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