Journal of

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Introduction :Acute myocardial infarction (AMI) is the most common cause of death in many countries, and also one of the common causes of death in Iran. As the death rate due to AMI is not clear and the survival rate of these patients had not yet been studied in the city of Yazd, this study was undertaken. Methods and materials : This was a survival study performed in Yazd between the years 2000 and 2002. 210 patients with definite AMI (according to clinical findings, ECG and enzyme criteria) were enrolled in this study (case series). They were admitted to Shahid Rahnemoon Hospital of Yazd (A general hospital). Results : The population under study included 161 males with mean age of 5914 years and 59 females with mean age of 6610 years. Frequency of hypertension, diabetes mellitus, hypercholestrolemia, hypertriglyceridemia and smoking was 27%, 22%, 20%, 22% and 32%, respectively. All risk factors except smoking were more common in females than men. 83.3% of infarctions were Q-wave infarctions, 16.7% non- Q-wave infarctions. 53% inferior wall and 40% were anterior wall infarctions. Infusion of streptokinase was done for 62% of patients. Mean ejection fraction of left vantricle was 48% in males and 45% in females. In-hospital mortality rate was 12.4% and higher in patients older than 70 years, diabetics, and anterior wall infarction patients. It had no correlation with sex. Surprisingly, smoking was accompanied with a very low in-hospital mortality rate. Conclution : One – year mortality rate of the patients in this study was 16.7% . It was higher in females, diabetics, anterior wall infarction patients and those with an ejection fraction less than 45%. The one year mortality rate in smokers was comparitively lower than non smokers in this study.

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Introduction: Several studies have evaluated the association of admission blood glucose levels and short and long term mortality after myocardial infarction and have had different results. The aim of this study was evaluation of association between admission blood glucose levels and in-hospital and one year mortality in non-diabetic patients with AMI. Methods: In this study, demographic, clinical and Para clinical data of 120 non-diabetic patients with AMI on admission was collected and analyzed. The patients were followed for one year. Blood glucose level ≥ 140 mg/dl was defined as hyperglycemia. Results: 78% of patients were men. The mean age and admission blood glucose level was 63+13 years and 146+76mg/dl, respectively. Death due to cardio vascular causes was seen in 20% of patients in hospital and 9.8% during the one year follow up. The mean admission blood glucose level in patients who died in hospital was significantly more than live patients and also had an influence on the in-hospital outcome. Every 100mg/dl increase in blood glucose level was associated with 11% increase in in-hospital mortality risk in non-diabetic patients. Conclusion: Our results demonstrate that admission blood glucose level is a good marker for diagnosing patients with worse prognosis after AMI. We suggest that later studies should focus on optimal control of hyperglycemia with insulin in patients with AMI.

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Introduction: Coronary heart disease is the most common cause of myocardial ischemia. The present study was aimed to evaluate the effect of resveratrol and aerobic exercise together and singularly on some cardiovascular risk factors in rat model of acute heart failure due to isoproterenol application.
Materials and Methods: In this experimental study, 46 male Wistar rats were divided into five groups randomly as follows: the healthy control (CON), isoproterenol induced myocardial infarction without implementation (ISO), resveratrol treated rats (ISO+RES), exercise treated rats (ISO+EXE) and combination of resveratrol and exercise groups (ISO+RES+EXE). Rats in the resveratrol groups received daily dose of 25 mg/kg/bw of resveratrol and exercise groups ran 1 h/d and 8 weeks on treadmill. Subsequently, all animals received subcutaneous isoproterenol on two consecutive days at the end of experiment. Then, animals anesthetized and blood samples were collected for analysis.
Results: The results showed that pretreatment with a combination of resveratrol and aerobic exercise led to a significant reduction in troponin-I in the animals. Also, exercise training, resveratrol and combinations of them were prevented the increasing CRP indices, but there was not significant effect in these groups (P> 0.05). Pretreatment with exercise training as well as combination of resveratrol and exercise training caused a significant decrease serum cholesterol and triglyceride levels were compared to the isoproterenol group (P≤ 0.001). Pretreatment with resveratrol, exercise training and a combination of both significantly increased in HDL-C and pretreatment only in mixed group led to significant decrease in LDL-C compared to the isoproterenol group (P= 0.001).
Conclusion: Regular exercise and resveratrol supplementation is likely to be effective on cardiovascular risk factors and the combination of the two variables in the prevention of inflammation and will have a significant role in heart damage caused by myocardial infarction

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Introdution: The rapid and accurate diagnosis of acute myocardial infarction is essential for effective treatment. Recently, troponin has been introduced as a biochemical marker for early diagnosis of acute myocardial infarction. Platelet parameters (P-LCR, MPV, PDW) play a key role in the pathophysiology of acute coronary syndrome. The aim of this study was to evaluate platelet indexes in the patients with acute myocardial infarction.
Methods: In this cross- sectional descriptivestudy, 345 patients with acute myocardial infarction who referred to Shariati Hospital with chest pain were examined in 2018. Troponin was measured by Enzyme-Linked Fluorescence Assay. The platelet indexes of the patients were determined by Hydrodynamically focused detection method.
Results: The results of Spearman correlation test between the three variables MPV, PLCR and PDW showed that there was a significant relationship between platelet parameters. Spearman correlation coefficient between two variables PLCR and troponin also showed a significant positive correlation.
Following an increase in the proportion of large platelets, the serum levels of troponin were increased in the affected patients. Mean of the MPV, PLCR and PDW were obtained (10.37, 27.74, 12.15femtoliter), respectively.
Conclusion:Platelet indexes of the MPV, PLCR and PDW can be considered as potent and non-dependent prognostic factors in the patients with acute myocardial infarction. In this study, P-LCR was more pronounced than other platelet indexes.