Mostafa Eghbalian, Sasan Amiri, Ghodratollah Roshanaei, Hossain Esfahani, Mohsen Ahmadi, Negar Assadi Sajadi,
Volume 25, Issue 11 (2-2018)
Abstract
Introduction: Childhood cansers are the second leading cause of death among children. Since the incidence and prevalence of malignancies are different in different regions and there are several cultural and environmental factors involved, the aim of this study was investigating epidemiology of common malignancies in children in Hamedan Province during the years of 1386-1395.
Methods: In this cross-sectional study, the population study was the children with malignancies referred to Besat's Hospital in Hamadan Province. The collected data were analyzed using SPSS 20 software. Descriptive indices and Chi-square test were used in this study.
Results: All available records showed that the malignancy was more prevalent in boys in freqency (57/7%). Most acute lymphoblastic leukemia (ALL) patients were 1-9 years, most acute myeloid leukemia (AML) patients were older than 9 years and most other malignancies were 1-4 years and over 9 years. The number of blood platelets (PLT) and the white blood cells (WBC) of the majority of patients in other malignancies, respectively, were greater than 100,000 and less than 50,000. For acute lymphoblastic leukemia and acute myeloid leukemia patients, the number of PLT and WBC were less than 100,000 and less than 50,000, respectively. The most clinical symptoms for acute lymphoblastic leukemia patients were fever and pale, fever and bleeding for acute myeloid leukemia AML patients, and finally masses and fever for patients with other malignancies.
Conclusion: Although the results of the family cancer were consistent with expected results concluded of similar studies, but the incidence of other malignancies in females was different (51/1%) with the results of some other studies.
Shiva Mosadegh Manshadi, Fatemeh Nadali, Mohammad Reza Shams Ardekani,
Volume 29, Issue 3 (5-2021)
Abstract
Introduction: Prunus armeniaca is one member of the Rosaceae family. Antitumor activity of this family on the colon, prostate, bladder, cervix, lung and breast cancers has been proven in previous research, which is attributed to a natural compound called amygdalin. Therefore, in this study, we investigated the effect of apricot kernel extract on acute leukemia that has not been studied before.
Methods: In this experimental study, Aqueous, ethyl acetate, and hydro alcoholic of the Armeniacae semen extracts were prepared. The NALM-6 and KG-1 cell lines were treated with different doses of extracts; cell viability was investigated with MTT test and using double staining fluorescent, cell apoptosis was detected. Cell cycle progression was analyzed, using a BD Cycle TEST PLUS DNA Kit.
Results: The results showed that different extracts of Prunus armeniaca induced dose-dependent inhibition in both Kg1 and Nalm6 cell lines. According to the results of MTT test, the strongest IC50 in Kg1 and Nalm6 cell lines was related to the 48h effect of ethyl acetate extract of Prunus armeniaca. Fluorescent microscopy analysis showed apoptosis. The ethyl acetate extract application in both cell lines increased the number of cells in the G0 / G1 phase and decreased the number of cells in the G2 / M phase.
Conclusion: It seems that ethylacetat extract of Prunus armeniaca can reduce the proliferation of Kg1 and Nalm6 cell lines, probably by regulates cell cycle progression.
