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Showing 4 results for Acetaminophen
Evaluation of Cellular Toxicity for Cisplatin, Arsenic And Acetaminophen in the Cancer and Normal Cell Line
M Shokrzadeh, F Hosseini- Shirazi, S Saeedi Saravi,
Volume 15, Issue 3 (12-2007)
Abstract
Introduction: Cell culture is a process in which the cells ware isolated from original tissue, dispersed in liquid media and then placed in culture plate where the cells adhere together and propagate. Today, this method is used for assessment of cell toxicity, its mechanisms and effect of different compounds on intracellular components. Methods: Clonogenic assay was used for assessment of cell toxicity and amount of cell death after a specific time during which cells were exposed to different compounds. Thus, IC50 in caner cell lines (HePG2, SKOV3 and A549) and normal cell (LLCPK1, CHO and HGF1) was assessed after exposure to cisplatin, acetaminophen and arsenic. Results: Results showed that acetaminophen has maximum resistance and minimum sensitivity in CHO line with IC50=16.7±1.06 HePG2 with IC50=18.6±1.29. On the other hand, cisplatin showed minimum resistance and maximum sensitivity in HePG2 with IC50 = 0.87±0.07 and HGF1 with IC50 = 1.6±0.21 and lastly, arsenic showed minimum resistance and maximum sensitivity in A549 with IC50 = 4.59±0.29 and LLCPK1 with IC50= 1±0.37. Discussion: According to the evaluated IC50, there were differences between results of sensitivity of cell lines exposed to the three drugs (P<0.05). Entirely, resistance in cancer cell lines was lower than normal cells. The results showed the importance of cell defensive mechanisms encountering different substances like glutathione.
Orally Administered Stevia Extract Reduce Acetaminophen-Induce Hepatic and Neural Side Effects in Mice
Maryam Setorgi , Majid Hassanpour-Ezatti, Zahra Mousavi ,
Volume 26, Issue 1 (4-2018)
Abstract
Introdution: Oral consumption of Stevia extract increased the antioxidants' level in the body. In this study, the effect of Stevia extract consumption was investigated against neurological and liver complications caused by acute and chronic toxicity of acetaminophen administration in mice.
Methods: In acute experiment, NMRI mice (n=12) received stevia extract (400 mg/ml) in drinking water for month, and then injected with a single high dose of acetaminophen (600 mg/kg, i.p.). In chronic experiment, the mice (n=6) was received stevia (200 and 400 mg/ml) in the drinking water together with acetaminophen (4.5mg/ml) for a 30 days. Mice coordinating movement was examined by crawling test along a rope. The serum level of alanine transaminase (ALT) and asparate transaminase (AST) and histopatology of mice liver was evaluated. All data were statistically processed using SPSS 20.0 software. The chi-square test and one-way ANOVA was used to analyze the data.
Results: Uncoordinated movement was observerd in 75% of mice after chronic acetaminophen application (p<0.01) and pretreatment with Stevia completely reversed effect of acetaminophen. Acetaminephen was significantly (p<0.01) increased serum AST and ALT and Sativa extract dose dependently reduecd the acetaminophen effects. Pretreatment with both dose of stevia cause reduction of chronic acetaminophen induced liver necrosis symptoms.
Conclusion: Oral stevia extract consumption can prevent from neural and hephatic signs of acetaminophen toxicity.
Nomadicating the Index of Sleep and Wakefulness from the Pyramid Creating and Maintaining the Health of Islamic Islamism
Abbas Ali Papoush, Akbar Afarinesh, Abulqasem Assi Mozneb ,
Volume 28, Issue 2 (6-2020)
Abstract
Introduction: The present study entitled  Nomadicating  of the sleep and wakefulness index from the source of the creating and maintaining of the health of Islamic baring has been done using a qualitative analytical-descriptive research method based on library studies. Unfortunately, the results indicated that despite the precise and expansive attention that the verses and recommendations of the great elites have emphasized on the importance of the well-being of the soul in the creating and maintaining of the health, and the scientific and practical solutions attributed to this, most of this material is neglected. Most people and every day diseases and clinical interventions are at the level of quality and life expectancy of human beings. However, the results of this study suggest that new scientific findings, as needed, should address issues related to sleep and behavior, including forbidden sleep time, places where prohibition of sleeping, proper sleep, sensitive hours, wakefulness, and effects of the mental and psychological state of people from the above mentioned nature in these situations, as well as the rituals before going to bed, waking up and recovering properly from the bed in order to minimize the sudden increase in blood pressure and its links with people's mood, the amount of sleep and the permission or unauthorized sleep during the day, etc. In this research, the answers of many people in this regard were provided.

Comparative Study of the Effect of Indomethacin and Acetaminophen on Pain after Collagen Cross-Linking Surgery
Mohsen Gohari, Seyed Hamid Mirhosseini, Faezeh Mazidi Sharaf Abadi, Hossein Fallahzadeh,
Volume 30, Issue 9 (12-2022)
Abstract
Introduction: One of the surgeries that needs to be considered after pain and discomfort is corneal cross-linking of the cornea. The aim of this study was to compare the effect of indomethacin and acetaminophen oral surgery before surgery on postoperative pain in the patients undergoing collagen cross-linking surgery.
Methods: The present study was a double-blind clinical trial study that was performed on all the patients undergoing collagen cross-linking surgery. Fifty patients were divided into two groups of 25 patients receiving acetaminophen 500 mg and indomethacin 75 mg before surgery. VAS scale was used to determine the severity of pain. Data were collected through a pain questionnaire and statistically analyzed using SPSS16 software.
Results: In the acetaminophen group, 60% were female and 40% male, and in the indomethacin group, 64% were female and 36% male, which were similar in terms of gender. The mean age in the acetaminophen group was 24.28±5 and in the indomethacin group was 24.04±4. The two groups were similar in the case of age. Based on Visual Analogue Scale (VAS) after collagen cross-linking surgery, the pain intensity was 6.29 in the acetaminophen group and 7.61 in the indomethacin group, respectively, which was significantly lower in the acetaminophen group. Moreover, there was no significant difference between the amounts of postoperative pain in the two groups.
Conclusion: Oral administration of acetaminophen before corneal cross-linking surgery was more effective in reducing postoperative pain than indomethacin, while there was no difference in the number of postoperative analgesics between the two groups during 24 hours postoperation.

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