Showing 11 results for Vahidi
Mr Vahidi, J Ayatollahi, Gh Karimi, A Mollasadeghi,
Volume 15, Issue 4 (Winter 2008)
Abstract
Introduction: Glaucoma is one of the leading causes of blindness throughout the world. Some studies have suggested a relationship between glaucoma and sensorineural hearing loss, while others have found no evidence of an association. We performed a study to determine whether there is a significant difference in hearing of patients with glaucoma and a match control population.
Methods: In this cross-sectional study, from February, 2005 till April, 2006, 44 patients with glaucoma were studied. The age range was between 15 to 60 years. After taking a complete medical history, those suffering from presbycusis, history of exposure to ototoxic drugs and substances and history of ear surgery were excluded from the study. All of the patients were cases of open-angle glaucoma, and were surveyed separately for normal-pressure glaucoma. Then complete audiometric tests (PTA, SDS, SRT, Impedance) were conducted for all of them, and the results compared with a control group.
Results: There was no statistically significant difference between the case group and control group in PTA, SDS, and SRT, except for Normal Tension Glaucoma (NTG). There wasn't any statistically significant difference between two groups with respect to age, gender, and history of diseases. In the NTG group, significant difference was seen only in high frequencies.
Conclusion: As mentioned, there was a statistically significant difference between NTG group and control group. It is therefore recommended to conduct complete audiometric tests and histopathologic examinations in this group for early detection of hearing loss and application of rehabilitative measures.
F Ezoddini -Ardakani, Mh Akhavan Karbasi, Ar Vahidi, N Mirjalili, N Eslampour,
Volume 16, Issue 1 (Spring 2008)
Abstract
Introduction: Hypercholesterolemia is a metabolic disorder that ultimately results in arterial sclerosis and complications like hypertension and coronary arterial diseases. Various drugs have been used for the treatment of this condition and many studies are underway for introducing new drugs. Chitosan and Salvadora Persica are two such drugs. Chitosan is produced by deacetylation of chitin which is present mainly in the exoskeleton of crustaceans. The aim of this invitro study was to study the effects of these two drugs on blood lipid levels.
Methods: In this Interventional Laboratory Trial, 30 mature vistar rats weighing 200-250 grams were selected and after a period of two weeks in order to allow them to adapt to their surroundings, they were allotted randomly to 6 groups. The rats were then fed for a period of 15 days with normal or fatty diet, with or without the drugs. Chitosan in pure powder form and persica in the form of hydro alcoholic salvadora persica stem extract were added to the diet of the respective study groups. At the end of this period, blood samples were taken in order to measure cholesterol, triglyceride, HDL and LDL levels. Data was analyzed statistically using SPSS software program and Scheffe, ANOVA and Descriptive statistical tests.
Results: Both chitosan and persica decreased cholesterol and LDL levels in the groups ingesting fatty diet (P< 0.05) and the mean decrease was not statistically different for the two drugs. (P > 0.05). The two drugs had no effect on triglyceride and HDL levels. (P > 0.05) Both chitosan and persica had no effect on blood lipid levels of subjects on normal diet whose cholesterol levels were normal (P > 0.05).
Conclusion: Persica and chitosan have similar effects on reduction of cholesterol and LDL levels in cases of hypercholesterolemia, but have no effect on triglyceride and HDL levels.
Mh Dashti-Rahmatabadi, Ar Vahidi Merjardi, Aa Pilavaran, F Farzan,
Volume 17, Issue 2 (Spring 2009)
Abstract
Introduction: Since time memorial, herbal medicine has played an important role for relief of various symptoms including pain relief. Many researches have focused on the curative as well as antinociceptive effects of herbal extracts. Cinnamon Zeylanicum has long been prescribed in traditional medicine for the treatment of inflammatory-related diseases such as rheumatisms, bronchitis and muscle pains. However, there is little if any scientific research indicating this effect
Methods: This experimental study was carried out in Shaheed Sadoughi Medical School on 25 Wistar Rats (200-300grams) randomly divided into 5 groups. In this study, the analgesic effect of intraperitoneal administration of hydro-alcoholic Cinnamon extract in different doses (50,100,500mg/kg) was assessed by using Formalin Test (for chronic pain) during 1hr. post Formalin injection.
Results: Our results indicated that cinnamon extract in high dose (500mg/kg) decreased the chronic pain intensity in the 2nd phase of formalin test. This analgesic effect was significant (P<0.001) as compared with sham group, but the lower doses (50 &100mg/kg) of cinnamon extract did not show any analgesic effect on chronic pain in Formalin Test.
Conclusion: Data from this study confirms the analgesic effect of high doses (500mg/kg) of cinnamon extract on chronic pain in Formalin Test which may be due to anti-inflammatory effect of this plant material.
Sj Mir Mohammadi, Ak Morovati, Mr Haji Esmaeili, M Jalili, S Vahidi, M Forate Yazdi, M Moghimi, A Barkhordari,
Volume 17, Issue 2 (Spring 2009)
Abstract
Malignant mesothelioma of the tunica vaginalis constitutes a very rare but often fatal malignancy of the male genitalia. This diagnosis should be suspected in patients exposed to asbestos and those presenting with clinical symptoms of either hydrocele or inguinal hernia.
We report here a case of malignant mesothelioma of the tunica vaginalis. A 69-year-old man with a left hydrocele and inguinal mass was referred for left inguinal orchidectomy and hernioraphy. Histologic examination showed a malignant mesothelioma.
Malignant mesothelioma of the tunica vaginalis testis is a very rare occupational neoplasm with highly aggressive biological behaviour. Treatment is difficult, and widespread local invasion and/or metastatic disease at presentation are associated with a poor prognosis.
Mh Baradaranfar, G Karimi, A Molasadeghi, S Atighechi, Mr Vahidi, Mh Dadgarnia, A Mirvakili, H Alimohammadi,
Volume 18, Issue 3 (Aug/Sep 2010)
Abstract
Introduction: Otoacoustic emissions are low density sounds produced from intact cochlea measureable in the presence of an intact conduction structure. The goal of this study was to assess the surgical success rate after stapes surgery by standard audiometric tests, Distortion Product Otoacoustic Emission (DPOAE) and Transient Evoked Otoacoustic Emission (TEOAE) as methods of evaluation of postoperative hearing.
Methods: A descriptive-analytic study was conducted on 50 patients with otosclerosis at Yazd Shaheed Sadoughi Medical University from March 2004 till October 2007. TEOAE, DPOAE and other behavioral audiometric tests were performed before, three months and six months after surgery on patients and results were compared.
Results: The air-bone gap threshold decreased significantly in audiogram of patients after surgery. Prior to surgery, TEOAE and DPOAE responses were not recordable in any of the patients, but after surgery, they were recordable in only two patients.
Conclusion: Although conductive hearing loss improved significantly in patients who underwent successful stapes surgery, OAE tests were recordable in an insignificant number of patients. Therefore, this is not an optimal method for evaluating the surgical success rate.
F Haghiroalsadat, A Vahidi, M Sabour, M Azimzadeh, M Kalantar, M Sharafadini,
Volume 19, Issue 4 (Sep-Oct 2011 2011)
Abstract
Introduction: Iran is one of the greatest and the most divergent resources of medicinal plants. Cuminum cyminum is one of the important and valuable medicinal plants of our country with such medical effects as anti-seizure, anti- epilepsy, stomach-strengthening, diuretic, anti-flatulence and maldigestion. The aim of this research is to assess the chemical components and antioxidant effects of the seed essence of this plant.
Methods: The seed essence from southwest mountains of Behabad, Yazd was extracted by Clevenger apparatus, then segregation and recognition of components was performed by Gas Chromatography(GC) and Gas Chromatography-Mass Spectrometry(GC-MS) methods. The DPPH test was used for estimating antioxidant effects and Follin-Ciocalteu method was used for estimating the quantity of phenol compounds. This study was an applied research.
Results: Components identification revealed that propanal (26.19%), 1-phenyl-1-butanol (16.49%), γ-Terpinene (13.04%) and benzene methanol (25.4%) had the highest percentage in the essence. The antioxidant test showed a high antioxidant effect with IC50 of 1.49 µg/mg and a high phenolic component percentage of about 162.62 mg/g.
Conclusion: The propanal, the main component of seed essence, has a wide range of applications in industries and pharmacy. The result of this research showed a much higher antioxidant activity for native Cuminum Cyminum of Yazd province comparing the previous similar studies about this plant in other areas.
M Dehghani, Ar Vahidi, Mr Moin, F Haghiroalsadat , M Sharafaldini, Mh Sheikhha ,
Volume 20, Issue 3 (Jul-Aug 2012)
Abstract
Introduction: GSTM and GSTT are subclasses of glutathione s-transferase that is present on human sperm surface and plays an important role against oxidative stress. This study aimed to investigate the polymorphisms of GSTT1 and GSTM1 in regard to sperm parameters.
Methods: This case-control study involved 46 men with varicocele and 48 men without varicocele. Semen analyses were carried out according to WHO guidelines. Blood DNA was extracted using salting out procedures. Polymorphism of GSTT1 and GSTM1 genes was determined trough multiplex-PCR respectively.
Results: Frequencies of GSTM1 null genotype in men with varicocelc and men without varicocele groups were 60.9 and 41.7 respectively. There were no statistically significant differences between Gstm1 null and positive genotype in two groups (p>0.05). Frequencies of gstt1 null genotype in case and control groups were 47.8 and 50 respectively. There were no statistically significant relationship between gstt1 null and positive genotype in two groups (p>0.05).
Conclusions: Deficiency of enzyme activity in gstm1 null genotype did not affect morphology as well as slow and quick progressive of sperm but caused the significant decrease in count of sperm between gstm1 null and positive genotype. In the case of gstt1, gstt1 null genotype did not affect sperm parameters that may be related to compensate activity of other genes in this super family.
M Moharrami Fard, A Mohammad Eini, N Vahidi, M Ahmadifar, N Kalhor, Mm Gholambabaeian,
Volume 23, Issue 3 (May-Jun 2015)
Abstract
Introduction: Peganum harmala from the zigophilauses family has compounds such as: alkaloid, saponine steroid and lignin which in used as a traditional medicine with antibacterial, anti-tumor, inhibition of MOA enzyme, and stimulation of the nerves system. Therefore, the aim of the present study was to evaluate the effect of the methanolic extract of Peganum harmala on serum levels of thyroids hormones parameters of adult rats.
Methods: In this experimental study, conducted at Academic Center for Education, Culture and Research (ACECR) of Qom in 2012, 60 adult female rats weighed approximately 200±10 grams were divided into 4 groups: the control group, and 3 experimental groups (100,200,400 mg/kg Peganum harmala oral extract daily for 60 days). Finally by collecting the blood samples of the animals, serum level of TSH, T3 and T4 were measured and the collected data were analyzed via SPSS software utilizing ANOVA.
Results: The study results revealed that the 200, 400 mg/kg Peganum harmala extract significantly reduced the TSH, T3, T4 levels in rats, whereas experimental group of 100 mg/kg extract Peganum harmala did not demonstrate any significant changes.
Conclusion: The study results indicated that the Peganum harmala extract might be used for treatment of hyperthyroidism and its related complications. However further studies are necessitated to explore this concept.
Mehrdad Talebi, Dr Mohammad Yahya Vahidi Mehrjardi,
Volume 27, Issue 5 (10-2019)
Abstract
Over the past decades, progression in genetic element manipulation, and consequently, the treatment of diseases has been remarkable. It is worth noting that these genetic manipulations perform at different levels, including DNA and RNA. The earlier genomic editing techniques, including MN, ZFN , TALEN , performing their functions by creating double-stranded breaks (DSBs), and after breakage, the cell tries to repair the breakage through two systems, homologous recombination and non-homologous end joining. CRISPR/Cas technology has been discovered recently, and has become the most widely used genome-editing tool, mainly due to its capabilities and those added to this through the genetic engineering. In this study, we aimed to introduce a variety of CRISPR classes in the elementary parts, and then the modified CRISPR systems developed to increase the efficiency and specificity of the system and provide acceptable results will be introduced.
In this study, for three months in the fall and winter, Pubmed and Web of science sites searched for keywords such as CRISPR, Types of CRISPR, gRNA, Cas9, and CRISPR-Cas9 nickase that eventually resulted in about four hundred Sixty-one articles, and some of these articles after closer study, reviewed in this article.
Genetic engineering techniques have successfully transformed this system into the most efficient genome editing tool in recent years. Researchers are working on a system to treat various diseases by resolving problems such as high specificity, cutting off non-target sites, how to move to a cell, and setting up a proper repair system.
Fatemeh Naghd Abadi, Bahman Vahidi,
Volume 29, Issue 1 (3-2021)
Abstract
Introduction: Hyperthermia is one of the noninvasive methods of treating cancer. In this method, heat can be generated in several methods. One of these methods is injecting magnetic nanoparticles as a solution into the tumor site and place it in a magnetic field.
Methods: The study was analytical one, modeling was performed using computational methods, and in vitro experimental data were used as the boundary conditions. The problem was solved with a geometry consisting of different layers of skin, adjacent tissue, tumor and injection site and assuming axial symmetry. The problem was solved with a geometry consisting of different layers of skin, the adjacent tissue, the tumor and the injection site and assuming axial symmetry. The effect of different injection sites, effect of performing two injections with a smaller volume comparing with an injection with a large volume, and finally the effect of the injected solution on the temperature distribution of the tumor was investigated.
Results: Results showed that injections with a smaller volume of solution in different sites would have better results, so that more parts of the tumor would reach to a temperature above 42°c, which is the temperature needed for having cancer cells died. Injection with the temperature of 37°c would be more effective than injection at room temperature and reached the desired temperature in less time.
Conclusion: According to the novelty of this investigation in assuming data from empirical experiments on the solution containing cobalt ferrite nanoparticles coated with polyethylene glycol as the boundary condition of the problem in modeling, the study is an important step in a more precise prediction of the clinical conditions occurring through using these methods of hyperthermia.
Salman Sadeghzadeh, Mahmood Dehghani Ashkezari, Seyed Morteza Seifati, Mohammad Yahya Vahidi Mehrjardi, Sara Sadeghzadeh,
Volume 30, Issue 3 (6-2022)
Abstract
Introduction: Biomarkers would significantly improve the early detection of the disease and identification of individuals at risk of emerging complications. Diabetes mellitus is a group of diverse and complex metabolic disorders. Both type 1 diabetes (T1D) and type 2 diabetes (T2D) mellitus are associated with distinct alterations in the profile of MicroRNAs (miRNAs) in the blood, which are sometimes detectable several years before the disease manifests. Lately, considerable attention has been paid to the role of miRNAs as biomarkers for T2D. The aim of this study was to review the expression of different miRNAs in pre-diabetic (per-T2D), T2D and healthy groups.
Conclusion After evaluating several articles, including main articles, meta-analysis and review studies, it was found that the expression of micRNAs was statistically different in healthy, pre-T2D and T2D groups. In addition, the expression of specific miRNAs is useful in preventing disease and modifying gene structure.
This study indicated that the plasma expression level of miRNAs could be considered as a non-invasive and fast tool for the separation of pre-T2D individuals from their healthy counterparts.
