Showing 17 results for Shiri
Mb Owlia, Gh Alishiri, A Bahrami-Ahmadi, J Shakeri ,
Volume 12, Issue 2 (summer 2004)
Abstract
Familial Mediterranean fever (FMF) is a hereditary condition which is characterized by recurrent episodes of fever and abdominal pain. On the other hand, Behcet`s disease (BD) is an immune mediated condition typified by recurrent oral aphthous lesions, inflammatory eye disease and multiple organ involvement. Association of these two conditions is rare. We present a pair of twins with FMF and BD in their mother.
A Haghighi, Mb Owlia, Gh Alishiri,
Volume 13, Issue 1 (spring 2005)
Abstract
Diabetic Muscle Infarction is a rare condition involving poorly controlled diabetic patients. This is a manifestation of diabetic microvasculopathy.
In this article we present a diabetic man, who presented with left-sided distal thigh pain and left knee joint effusion. Further evaluations led to the diagnosis of diabetic muscle infarction (DMI)
H Allahverdipour, A Farhadinasab, S Bashirian, H Mahjoob,
Volume 15, Issue 4 (Winter 2008)
Abstract
Introduction: Narcotic drug abuse and illicit use of drugs is a major, complicated multifactorial phenomenon affecting most of the societies today. Incidence of drug abuse among adolescents is very high. Adolescents become addicted to substances more quickly than adults. The aim of this study was to assess the pattern of drug abuse among male adolescents in Hamadan.
Methods: This study was a descriptive study and samples (n=400) were collected on the basis of snowball sampling method. Information was collected individually through completion of a researcher-designed questionnaire including demographic and epidemiological indices, perceived familial support, religiosity, and locus of control.
Results: The results showed that smoking (93%), alcohol (92.5%), marijuana (64.3%), and opium (57.8%) use were very high, while LSD (4.8%) and Cocaine(2.3%) use was rare. 77.8 % of adolescents began drug abuse between 12 and 18 years of age. Moreover, sensation seeking (26.5%), individual interest (24.8%), and peer pressure (22%), were the main reasons for drug abuse.
Conclusion: As initial smoking, alcohol and marijuana use play an important role in determining the future addiction of adolescents to narcotics, yearly surveillance programs in the country and evaluation of etiological factors of narcotic addiction need to be studied carefully. All of the preventive and school programs designed for the young should take into account environmental, demographic and policy factors in addition to personal factors so that the programs have a maximum effect.
A Manookian, A Nejatisafa, K Ali-Moghaddam, A Shamshiri,
Volume 18, Issue 2 (Jun/Jul 2010 2010)
Abstract
Introduction: Bone marrow transplantation is one of the treatment modalities in many hematologic disorders. In recent years, bone marrow transplantation is increasingly being delivered in the outpatient setting. Some studies suggest that outpatient transplantation has many advantages. The aim of this study was to compare the quality of life in outpatient and inpatient multiple myeloma patients after bone marrow transplantation.
Methods: This research was a descriptive, comparative study. The quality of life of 35 multiple myeloma patients who had undergone bone marrow transplantation (20 outpatient and 15 inpatient) was assessed. An EORTC QLQ_C30 questionnaire was used for data collection. The questionnaire was completed on three occasions (before transplantation, 45 day after BMT and 90 day after BMT). Descriptive (mean, SD) and inferential statistics (Paired T Test, ANOVA Repeated Measures) were used for data analysis.
Results: Comparison of quality of life between inpatient and outpatient settings indicated that quality of life of outpatient group was significantly better than inpatient group in certain aspects including all functional scales, all symptom scales, physical functioning, nausea and vomiting, fatigue, role functioning and appetite loss, and after a period of 90 days after transplantation, there was a significant increase in quality of life of the members of the inpatient group with regards to social functioning (p=0.001), dyspnoea( p=0.05), insomnia(p<0.001) and diarrhea (p=0.07).
Conclusion: Although both transplantation methods have their own advantages, but considering the point that outpatient setting results in betterment of quality of life in certain aspects, it is advisable that patients should undergo bone marrow transplantation in an outpatient setting.
G Dastjerdi, V Ebrahimi Dehshiri, G Kholasezade, F Ehsani,
Volume 18, Issue 3 (High Risk Behavior Conference Supplement 2010)
Abstract
Introduction: Addiction as a social, health problem with its specific complications threatens societies. High risk behaviors such as violence, self mutilation, tattooing, shared injections and unprotected sex behaviors are some of the problems in addicts that need to be treated. One of these treatments is methadone therapy. The purpose of this study was to evaluate effectiveness of methadone in prevention or reduction of high risk behaviors in clients of a MMT center of Shaheed Sadoughi University of medical sciences of Yazd.
Methods: This study was done on 93 clients of a MMT center.Questionnaire for this study included items from MAP and questions about some other risky behaviors. This questionnaire was completed at onset of treatment and 6 months after. Data was analyzed with SPSS software program
Results: 89.2% of participants were married and 10.8% were single. 63.5% of them were in the20-40 years age group. Most commonly abused substances were heroin and opium. Before onset of treatment, 37.6% of participants had history of imprisonment, 35.5% had shared injections, 32.3%had had unprotected sex, 22.6%had tattooing and 5.4%had mutilated their own selves. Only 36.6% didn’t have any high risk behavior. These behaviors were more common in heroin users and in the20-40 years age group. After onset of treatment and during 6 month of MMT, 86% of clients didn’t have any risky behavior. Only 14%of them continued to have unsafe sex behaviors
Conclusion: Addiction can cause high risk behaviors. Data in this paper suggests that young age, heroin use, low education level and no or inadequate information about addictive substances and their consequences are effective and important factors that cause high risk behaviors. Treatment of addicts with methadone maintenance therapy plays an important role in reduction of risky behaviors. Development of appropriate and more MMT centers are recommended.
Ma Hosseinpour Feizi, S Shiri Torkamani, E Babaei, M Ghanbarian, V Montazeri, M Halimi,
Volume 21, Issue 5 (NOv-Dec 2013)
Abstract
Introduction: Krupple-like factor4 is a transcription factor which is involved in many cancers including Breast cancer. Breast cancer is the most common malignancy among women. Due to the high prevalence of these tumors, there are ongoing efforts to find molecular markers which can recognize nontumoral from tumoral tissues. Therefore, the aim of this study was to evaluate the potential usefulness of KLF4 as a potential diagnostic and therapeutic molecular marker in breast cancer.
Methods: In the current study, 31 tumoral and 21 non tumoral adjacent tissues were evaluated. Transcription levels were measured by Semiquantitative Reverse Transciptase-Polymerase Chain Reaction and were normalized by the ß2m as an endogenous PCR control. Data was analyzed by spss software, one-way ANOVA and T-test.
Results: The results showed that: 1) KLF4 is over expressed in Breast tumors rather than adjacent normal tissues. 2) KLF4 is an oncogene in breast tumors (at least in IDC type). 3) The KLF4 expression levels are related significantly with nature of malignant breast tumors.
Conclusion: Findings do not confirm KLF4 as a diagnostic marker in classification and identification of tumoral tissues from non-tumoral ones in breast, but we can use this marker to identify at least 50% of invasive Ductal Carcinoma in breast and utilize it as a potential predictive factor to demonstrate severity degree in various tumors.
Ar Kamali, A Zarei, E Moshiri, M Naziri,
Volume 22, Issue 5 (Nov-Dec 2014)
Abstract
Introduction: Pain is a complex medical problem that its postoperative inadequate control can produce adverse effects on patients’ physiological, metabolic and mental states. Adding new supplements can lead to an increased duration of analgesia. Therefore, this study aimed to compare the addition of neostigmine and ketamine to 0.25% -bupivacaine for epidural analgesia in increasing duration of postoperative analgesia.
Methods: In this double blind clinical trial, 90 patients aged over 50 years, candidate for elective hip surgery with ASA class I, II, were randomly divided to three groups: Neostigmine, Ketamine and control groups. All patients received 2cc/segment of 0.25%-bupivacaine for epidural anesthesia. Furthermore, 60 micrograms of neostigmine were added in first group and 40 mg of ketamine in the second group. Level of postoperative pain was based on VAS and duration of analgesia and amount of analgesic was compared between the three groups.
Results: The mean of pain score at 6 and 12 hours after surgery was significantly lower in the ketamine group than the other groups. Moreover, in neostigmine group, it was less than that of placebo group (P≤0.01). The mean of duration of postoperative analgesia in the Ketamine group was significantly higher than those of other groups and in neostigmine group it was more than placebo(P≤0.01). The mean dose of analgesic (Pethidine) was the least in the Ketamine group (P≤0.001).
Conclusion: The study findings revealed that utilizing Neostigmine and Ketamine with 0.25%-bupivacaine for epidural anesthesia increased the duration of analgesia for postoperative and reduced analgesic consumption that was reported to be more effective with Ketamine than Neostigmine .
R Bashiri, A Ghadiri-Anari, H Hekmatimoghadam, A Dehghani, A Najarzadeh,
Volume 22, Issue 5 (Nov-Dec 2014)
Abstract
Introduction: Type 2 diabetes is regarded as the most common and the most important metabolic disease which is progressively increasing in different societies. In this study, the effect of apple vinegar on lipid profiles and anthropometric indices was examined in Type 2 diabetes patients with dyslipidemia.
Methods: Sixty-two Type 2 diabetic patients with dyslipidemia were randomly assigned into a control (n=30) and an experimental group(n=32). The experimental group was instructed to use 10 cc of apple vinegar soluble in a glass of water two times a day 1 hr before each meal for 8 weeks.
Results: The participants’ serum lipid profiles( Cholesterol, TG,LDL and HDL) and also anthropometric indices(Weight, Height and Waist Circumference) were measured before and after the intervention. Finally, in spite of a reducing trend in cholesterol and LDL in apple vinegar group, no significant differences were observed between the two groups (pvalue>0/05).
Conclusion: The present study revealed that consuming 20 cc of apple vinegar daily had no effect on serum lipoprotein profiles and anthropometric indices in Type 2 diabetes patients with dyslipidemia.
Shirin Shahbazi, Mahnaz Torfeh,
Volume 24, Issue 12 (Feb-Mar 2017)
Abstract
Introduction: Uterine leiomyomas arise from the proliferation of smooth muscle cells. ACE gene encodes a convertase enzyme mainly secreted in vascular endothelial cells which is involved in the renin–angiotensin system and blood pressure controlling. This gene has an insertion/deletion (I/D) polymorphism correlates to serum and tissue ACE levels. The aim of this study is to elucidate the relationship between ACE gene variation and the development of myom.
Methods: The samples of 55 uterine leiomyoma patients and 78 healthy women were studied. After obtaining informed consent, blood samples were collected and DNA extraction was performed by Salting-out method. Genotyping was performed using PCR reaction. The amplified products were two bands of 190 and 490 bp, which represents D allele and I allele, respectively. Statistical analysis was done using Chi-square test.
Results: The D allele frequency was 0.55 in the patient group and 0.51 in the control group. The I allele frequencies in the two groups were 0.45 and 0.49, respectively. The results showed that taking the II genotype into account as reference genotype; homozygous DD individuals were at increased risk of uterine myoma (Odds ratio: 1.37). However, heterozygous ID showed a similar risk with the II genotype as the reference group.
Conclusion: High blood pressure is significantly associated with uterine fibroids. It has been shown that atherosclerotic damage of uterine blood vessels and the inflammatory process caused by it may play an important role in the development of uterine myoma. This study indicates a positive relationship between the ACE (I/D) polymorphism and the risk of uterine myoma. This finding is evidence of the important role of the renin–angiotensin system in the pathogenesis of myoma
Atena Dadgari , Yasini Seyed , Ellahe Shiri , Nahid Mazlom , Imane Bagheri , Motahare Sharaf Aldini ,
Volume 26, Issue 11 (Feb 2019)
Abstract
Introdution: Schizophrenia is a severe mental disorder, which may be accompanied by reduction in quality of life.The purpose of this study was to study the effect of education during discharge on the quality of life in the patients with schizophrenia.
Methods: The present study was an experimental study and research community is of the patients at the Comprehensive Psychiatric Center of Yazd Province, Iran. In this study, the patients (two experimental and control groups, n= 32 in each group) with schizophrenia were admitted to the Comprehensive Psychiatric Center of Yazd Province. For the experimental group, in addition to routine programs, the discharge program was performed for 6 hours in the hospital and a routine program was performed for the control group. Quality of life was measured with the quality of life inventory in both groups before the intervention and one month after discharge. Statistical analysis was performed by paired T test and independed T test(version 16)
Results: The groups were matched for demographic variables and quality of life score. At the end of the study, the quality of life and social skills (P <0.001) were significantly improved in the experimental group, but there was no significant change in the control group (P>0.05).
Conclusion: Increasing the quality of life is the benefits of training during discharge, which is important due to the chronic course of schizophrenia
Elahe Darvishi, Mahsa Minadi, Somayeh Mirsadeghi, Behrang Shiri,
Volume 28, Issue 9 (11-2020)
Abstract
Introduction: Much research has been carried out to improve drug delivery and targeted drug delivery to the body in order to minimize side effects, provide controlled delivery of the drug to the desired location and to achieve optimal therapeutic effects. Zeolitic imidazolate-8 (ZIF-8) is a subset of MOFs that are biocompatible, stable in the aquatic environment and have adjustable porosity. In addition, at pHs 5 or 6, the bond between imidazolate-zinc ions disappears and releases the drug. In this project, ZIF-8 was used as a curcumin carrier to improve the physicochemical properties and enhance the efficacy of lipophilic drugs in the treatment of cancer.
Methods: This research was a basic experimental study. ZIF-8 nanoparticles were fabricated by co-precipitation method. . In addition, to prove their pH sensitivity, curcumin was first encapsulated in situ in ZIF-8 and characterized by XRD, SEM, TEM, DLS methods. Then its release was investigated at two pH of five and 7.4 saline phosphate buffer. Finally, In vitro study by MTT assay was performed on prostate cancer cell line (PC3). Data were compared by analysis of variance (ANOVA) using SPSS version 16 software.
Results: After characterization of the nanoparticles by the mentioned methods, it was found that the nanoparticle dimensions were between 80-60 nm and the nanoparticle dimensions with curcumin were between 120-110 nm. In addition, in the synthesis of ZIF-8 nanoparticles, 72% of the drug was loaded, which is an acceptable amount.
Conclusion: These nanoparticles showed high capacity in the treatment of prostate cancer and minimal damage to healthy cells. It can be said that using this formulation for targeted drug delivery of cancer not only reduces the side effects of anti-cancer drugs but also increases their effectiveness and can also be used to deliver low-soluble or insoluble drugs in biological environments.
Jamal Jafari Nodoushan, Ahmad Shirinzadeh, Hamid Reza Soltani Gerdfaramarzi,
Volume 28, Issue 11 (1-2021)
Abstract
Introduction: Hydatid cysts are much less common in the abdomen than in the lungs, and the most common organ involved in the abdomen is the liver, although it is rarely seen in the spleen alone or in multiple organs. The patient was a 25-year-old man who presented with LUQ pain that started one month ago and with a mild non-intermittent nature and it gradually increased. On ultrasound of the patient, multiple cysts in the spleen area were reported. CT scan images also showed evidence of multiple Hydatid cysts. The abdomen was opened. There were several cystic masses that were carefully removed. After 5 days, the patient was in good general condition. oral Mebendazole was prescribed and the patient discharged from the hospital. Although splenic Hydatid cysts are very rare, they are associated with involvement of other organs in the abdomen, as well as the high risk of rupture and anaphylactic shock before and during surgery. This group of hydatid cysts requires special medical care and surgery. Conditions of involvement of several surgical intra-abdominal organs with special care before and during surgery are the basis of treatment of this group of patients.
Elahe Darvishi , Asra Amani, Somayeh Mirsadeghi, Behrang Shiri Varnamkhasti ,
Volume 30, Issue 3 (6-2022)
Abstract
Introduction: Photothermal therapy is a method of cancer treatment that plasmonic nanoparticles are used to convert infrared light into local heat. Due to the plasmonic properties of gold nanoparticles, this compound was used as a contrast agent. The aim of this study was to synthesize gold nanoparticles with different conjugations for photothermal therapy.
Methods: This research was an experimental study. The method used for the synthesis of spherical and rod gold nanoparticles in this research was the Seeding Method. The nanoparticles were then conjugated with various compounds such as rifampicin, quercetin and RGD. Then, the physical and chemical properties of nanoparticles were determined by DLS, UV-Vis and TEM methods. Cytotoxicity test was also performed on MCF-7 ((Michigan Cancer Foundation-7)) cell line. Cell viability was calculated using prism software. Differences were compared by analysis of variance (ANOVA) using SPSS version 16 software.
Results: In the UV test, two-peaked rod nanoparticles were observed in the range of 523 and 738 nm, and in the case of spherical nanoparticles at 535 wavelengths, which indicates the correct synthesis without impurities and with the appropriate size .In the cell test, a decrease in cell viability was observed compared to the control group. In the first 24 hours, spherical nanoparticles had the highest lethality to the point that at a concentration of 20 μg / ml, it had almost 50% lethality. In addition, after 48 hours at low concentrations, rod nanoparticles showed better results, so they were more suitable. By targeting these nanoparticles to specific cancer cells, in addition to being used to kill cancer cells, the effect of these nanoparticles on healthy cells can be prevented. By conjugating different compounds on the surface of these nanoparticles, cell uptake can also be increased and cancer cells can be killed using photothermal therapy.
Conclusion: According to the results obtained in this study, it seems that low-concentration of gold nano-rods are more suitable for photothermal therapy.
Abolfazl Hekmat-Shoar, Amirali Moodi Ghalibaf, Ali Shamshirian, Mohammadreza Abbaszadegan4, Bahram Memar, Mohammad Reza Motie,
Volume 31, Issue 4 (7-2023)
Abstract
Introduction: The present study was designed to investigate the relationship between COX-2 gene expression, clinicopathological symptoms, and prognosis of patients with gastric cancer.
Methods: The present cross-sectional study was designed to achieve the scientific aims among patients referred to the Imam Reza Hospital, Mashhad, Iran from 2008 to 2018. In this study, patients' demographic characteristics, clinical signs and symptoms, tumor findings, type of surgery, and COX-2 gene expression level (using Real Time PCR technique) were recorded. The data were analyzed by SPSS software (version 16), statistical tests, including Chi-square, Fisher's exact, Gamma coefficient, one-way ANOVA, or Kruskal-Wallis test at a significance level of 0.05.
Results: Out of 110 patients included in the study, 55 patients were evaluated according to the criteria. Among them 21 (38.2%) patients had decreased levels of gene expression, in 18 (32.7%) patients gene expression was in the normal range, and in 16 (29.1%) patients increased gene expression was seen. The average survival months of patients after surgery were 23.41 ± 23.07 months. No statistically significant relationship was found between increased COX-2 gene expression and clinical signs, age, sex, survival (by month), tumor progression, type of surgery, histological features, family history of cancer, and other cases (P> 0.05); However, considering the annual survival in the annual classification showed a significant relationship with the expression of COX-2 gene (P=0.028).
Conclusion: Despite no significant relationship between COX-2 gene expression and studied parameters in the patients with gastric cancer in this study, the existence of a significant relationship between gene expression and annual survival of patients seems so important.
Mahnaz Mohammadi, Shirin Hafezi,
Volume 31, Issue 5 (8-2023)
Abstract
Introduction: Sea cucumber is one of the important aquatic animals that has many nutritional and medicinal properties and is of medical importance due to the presence of compounds with therapeutic and antibacterial effects. The purpose of this study was to investigate the antibacterial effect of selenium hybrid nanoparticles and sea cucumber extract on Escherichia coli, Micrococcus luteus and Bacillus cereus bacteria.
Methods: MIC evaluation method was determined for the cytotoxic effect of sea cucumber extract on microbial cells. To carry out this research, after collecting and extracting sea cucumbers, the cytotoxicity of this extract on microbial cells was determined using the MIC method. Then, the antibacterial effect of sea cucumber extract, selenium hybrid nanoparticle and the combined effect of sea cucumber extract and selenium hybrid nanoparticle on Escherichia coli, Micrococcus luteus and Bacillus cereus bacteria were evaluated. Statistical analysis was done using SPSS version 16 software.
Results: The results of the experiments showed that sea cucumber extract with different dilutions had an antibacterial effect on Escherichia coli bacteria, Micrococcus luteus and Bacillus cereus. These results also applied to the tests performed with selenium nanomedicine. Interestingly, after combining a certain amount of sea cucumber extract and selenium nanomedicine, a greater antibacterial effect was observed on the above-mentioned 3 bacteria.
Conclusion: The synergistic effect of sea cucumber extract and selenium nanoparticles has a higher level of antibacterial properties.
Samaneh Asadi, Shirin Moradkhani,
Volume 31, Issue 10 (1-2024)
Abstract
Introduction: Cuscuta, (Ces as Persian name) is a parasitic plant with different biological effects and applications. The metabolic profile and effects of the Ces depend on the host on which it grows. Its main components are phenols and flavonoids. Considering the antioxidant effects of these compounds, the purpose of this research was to investigate the antioxidant activities and total phenolic and flavonoid contents of Cuscuta as well as Mellissa officinalis and Alhaji murarum as hosts.
Methods: Aqueous, hydroalcoholic extracts of the Cuscuta grown on two hosts were prepared separately. Hydroalcoholic extracts of host plants were also prepared. Total phenolic and flavonoid contents were evaluated using Folin- Ciocalteu reagent and aluminum chloride colorimetric assays, respectively. In order to investigate the antioxidant activity, the ability of extracts to scavenge DPPH free radical (DPPH 2, 2-(diphenyl-1-picrylhydrazyl) and their capacity to reduce iron 3+ion were measured by FRAP method.
Results: The results showed that all the examined extracts have significant phenolic and flavonoid contents. The highest antioxidant activity was observed in hydroalcoholic extracts, which was proportional to the amount of phenolic and flavonoid contents in the extracts. In addition, the extracts of host plants were richer than the parasite extracts. The extract of Mellissa officinalis showed better effects than Alhaji murarum in all of four investigated factors.
Conclusion: According to the findings of the present study, the hydroalcoholic extracts of the Cuscuta plants are rich in phenolic and flavonoid compounds, which may be the cause of the antioxidant activity. Of course, the compounds and effects of Cuscuta depend on the host. In future studies, the plant can be grown in different hosts.
Mahshid Shiri, Mohammad Reza Fadai Chafi, Shahram Gholamrezaei,
Volume 32, Issue 2 (5-2024)
Abstract
Introduction: Exercise training is likely to be a non-pharmacological intervention to improve bone health in children and the elderly. The aim of this study was to investigate the effect of resistance-aerobic training on RUX2, CTX, RANKL and ALP biomarkers in rats of different ages.
Methods: In the present experimental study, 30 male Wistar rats were obtained from Instituto Pasteur of Iran and were divided into three groups according to their age: immature (2 weeks old), mature (6 weeks old) and elderly (96 weeks old). In each age group, the mice were randomly divided into two training (n=5) and control (n=5) groups. Six weeks of combined training included three sessions of aerobic training and three sessions of resistance training per week. Extracting genes by PCR method was used. One-way analysis of variance and Tukey's post hoc test and SPSS16 software were used. The significance level P≥0.05 was considered.
Results: One-way analysis of variance showed that resistance-aerobic training has had a significant effect on RUNX2, RANKL and ALP variables of rats in different age groups (P < 0.05). This significance was not observed in CTX variable (P > 0.05). On the other hand, the results of Tukey's RUNX2 test were significantly different between the adult training and elderly training groups (p = 0.019) as well as between the elderly control groups (p = 0.01) and adult training (p = 0.002). Regarding the RANKL variable, it showed that there was a significant difference only between the adult exercise group and the elderly control group (p = 0.01).
Conclusion: Resistance-endurance training probably increases absorption and reabsorption biomarkers such as RUX2, RANKL and ALP in immature, mature and elderly male rats.
