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Showing 2 results for Shamshiri
Comparative Study of Quality of Life in Multiple Myeloma Patients after Bone Marrow Transplantation in Outpatient and Inpatient Setting
A Manookian, A Nejatisafa, K Ali-Moghaddam, A Shamshiri,
Volume 18, Issue 2 (Jun/Jul 2010 2010)
Abstract
Introduction: Bone marrow transplantation is one of the treatment modalities in many hematologic disorders. In recent years, bone marrow transplantation is increasingly being delivered in the outpatient setting. Some studies suggest that outpatient transplantation has many advantages. The aim of this study was to compare the quality of life in outpatient and inpatient multiple myeloma patients after bone marrow transplantation. Methods: This research was a descriptive, comparative study. The quality of life of 35 multiple myeloma patients who had undergone bone marrow transplantation (20 outpatient and 15 inpatient) was assessed. An EORTC QLQ_C30 questionnaire was used for data collection. The questionnaire was completed on three occasions (before transplantation, 45 day after BMT and 90 day after BMT). Descriptive (mean, SD) and inferential statistics (Paired T Test, ANOVA Repeated Measures) were used for data analysis. Results: Comparison of quality of life between inpatient and outpatient settings indicated that quality of life of outpatient group was significantly better than inpatient group in certain aspects including all functional scales, all symptom scales, physical functioning, nausea and vomiting, fatigue, role functioning and appetite loss, and after a period of 90 days after transplantation, there was a significant increase in quality of life of the members of the inpatient group with regards to social functioning (p=0.001), dyspnoea( p=0.05), insomnia(p<0.001) and diarrhea (p=0.07). Conclusion: Although both transplantation methods have their own advantages, but considering the point that outpatient setting results in betterment of quality of life in certain aspects, it is advisable that patients should undergo bone marrow transplantation in an outpatient setting.
Investigation of the Relationship between COX-2 Expression, Clinicopathological Symptoms, and Prognosis of the Patients with Gastric Cancer
Abolfazl Hekmat-Shoar, Amirali Moodi Ghalibaf, Ali Shamshirian, Mohammadreza Abbaszadegan4, Bahram Memar, Mohammad Reza Motie,
Volume 31, Issue 4 (7-2023)
Abstract
Introduction: The present study was designed to investigate the relationship between COX-2 gene expression, clinicopathological symptoms, and prognosis of patients with gastric cancer.
Methods: The present cross-sectional study was designed to achieve the scientific aims among patients referred to the Imam Reza Hospital, Mashhad, Iran from 2008 to 2018. In this study, patients' demographic characteristics, clinical signs and symptoms, tumor findings, type of surgery, and COX-2 gene expression level (using Real Time PCR technique) were recorded. The data were analyzed by SPSS software (version 16), statistical tests, including Chi-square, Fisher's exact, Gamma coefficient, one-way ANOVA, or Kruskal-Wallis test at a significance level of 0.05.
Results: Out of 110 patients included in the study, 55 patients were evaluated according to the criteria. Among them 21 (38.2%) patients had decreased levels of gene expression, in 18 (32.7%) patients gene expression was in the normal range, and in 16 (29.1%) patients increased gene expression was seen. The average survival months of patients after surgery were 23.41 ± 23.07 months. No statistically significant relationship was found between increased COX-2 gene expression and clinical signs, age, sex, survival (by month), tumor progression, type of surgery, histological features, family history of cancer, and other cases (P> 0.05); However, considering the annual survival in the annual classification showed a significant relationship with the expression of COX-2 gene (P=0.028).
Conclusion: Despite no significant relationship between COX-2 gene expression and studied parameters in the patients with gastric cancer in this study, the existence of a significant relationship between gene expression and annual survival of patients seems so important.

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