Showing 21 results for Sami
A Mesdaghinia , F Samiee,
Volume 12, Issue 2 (summer 2004)
Abstract
Introduction: Recent studies have shown that cold water swimming stress (CWSS) produces analgesia. Although exact mechanism of the analgesia is until unclear, it may attributed to CCK receptors. On the other hand, the effectiveness of analgesic drugs for treatment of neuropathic pain is limited. In the present study, the effects of CCK receptor agonist caerulein and antagonist proglumide , both alone and together on the CWSS- induced analgesia was investigated and compared in normal mice and those whose sciatic nerve was ligated.
Material & Methods: In this research, fifty groups of nine male albino mice were used. As a model of neuropathy, the unilateral nerve ligation was made by a surgical procedure on the right hind limb. Pain sensitivity was measured by the hot plate test.
Results: Different CWSS regimes (0.5-3 min) induced time-dependent analgesia. Nerve ligation did not alter the CWSS induced analgesia. Caerulein (0.025, 0.05 and 0.1 mg/kg) induced analgesia in both nerve ligated and intact animals. Different doses of proglumide (20, 40 and 60 mg/kg) alone produced analgesic effect. The response of caerulein was not inhibited by proglumide. In the stressed mice, both drugs and the combination of them showed analgesia but there appeared to be no potentiation in CWSS- induced analgesia. Our results indicate no significant relationship between CCK receptors and the CWSS- induced analgesia.
Conclusion: Nevertheless, CWSS as an alternative to drug treatment in neuropathic pain requires more studies.
M Rahimian, A Hasan Zadeh, R Sami,
Volume 13, Issue 1 (spring 2005)
Abstract
Introdaction: The purpose of this study was to evaluate the therapeutic and side effects of erythropoietin in the management of anemia in chronic renal failure. In this study, 60 patients were given Erythropoietin subcutaneously three times/week for 2 months.
Methods: Mean hemoglobin of patients was recorded before beginning Erythropoietin and also one weeks, one month and two months after treatment.
Results: Mean hemoglobin value before treatment was 7.6 g/dl that increased to 9.08g/dl 2 months later. Hemoglobin levels were not dependent on the age and sex of the patient, but there was a meaningful difference between diabetics and nondiabetics.
Conclusion: The side effects of Erythropoietin in this study in order of frequency were as follows: Hypertension, A.V fistula thrombosis, allergy and seizure.
M Zakizadeh, Aa Sadeghian, M Bagheri Nesami , Ra Mohammadpour Tahamtan , F Salmeh, T Yaghoubi, J Abdolmanafi,
Volume 14, Issue 2 (Summer 2007 2006)
Abstract
Introduction: Though incarcerated populations are at a high risk of developing hepatitis C virus (HCV) infection, prisoners are not routinely screened for HCV infection. Approximately, 1 in 4 of the nearly
2 million prisoners in the U.S. is infected with HCV. Injection drug abusers are currently the main risk group. Among intravenous drug abusers over the world, the prevalence of HCV varies from 50-90% with an annual incidence of 10-30%. Prisons are a high risk environment for hepatitis C infection because of high incidence of drug abuse and high risk sexual activities. Serologic evidences show that HCV infection is present in one out of every three prisoners. The purpose of this study was to determine the seroprevalence of Hepatitis C infection and its associated factors among addicted prisoners in Khezrabad prison of Sari.
Methodss: This was a cross – sectional study done in September 2001 at the Khezrabad prison for addicts in Sari. 312 addicts participated in the study and were selected by simple random sampling method. Their blood samples were tested by third generation enzyme immunoassay (EIA-3: sensitivity 100%, specificity 100%) at Sari's blood transfusion center. The data was collected via a questionnaire and interview. 230 prisoners (74%) completed the questionnaires. Associated factors of Hepatitis C infection were compared in 82 anti-HCV positive addicts (the affected group) and 148 anti-HCV negative addicts (the unaffected group). There were no significant differences about confounding variables between the two groups. Statistical analysis was done by , t test and multivariate logistic regression analysis.
Results: Of the 312 addicted prisoners, 96 (30.8%) were anti-HCV positive. Major associated factors with Hepatitis C infection in the affected group included duration of addiction (mean 174 months), duration of imprisonment (mean 48 months), methods of drug usage (injection 82% and intranasal 44%), length of alcohol consumption for more than five years (60%), tattooing (66%) , shared usage of needles (31%) and razors (53%), multiple sexual partners (>74%) and the type of drugs (especially heroin 90% and hashish. 64%) (p<0.05) On multivariate logistic regression analysis,significant independent risk factors for HCV infection included tattooing (OR 100, 95% CI) , multiple sexual partners(OR4.97,95%CI)and history of surgery(OR 6.23,95% CI ) .
Conclusion: Hepatitis C infection is highly prevalent in addicted prisoners and high risk and unsafe behaviors are the main factors of contamination.
M Rahimian, R Sami, F Behzad,
Volume 15, Issue 1 (Spring 2007)
Abstract
Introduction: Osteodystrophy is one of the long term complications of chronic renal failure and is expressed in two formslow turn over and high turn over. It is an important cause of morbidity in patients with renal failure and if diagnosed and managed properly, many problems of these patients can be resolved. In this study we evaluated the prevalence of hyperparathyroidism in hemodialysis patients and its correlation with different factors.
Methods: This study was an analytic, observational study that was done by the cross- sectional method. We formatted a questionnaire for hemodialysis patients who were enrolled in the study over a period of 6 months. Fasting blood samples (5-10c.c) were drawn to measure levels of PTH(parathyroid hormone) ,calcium, phosphorous and alkaline phosphatase. Skull and wrist X-rays were also taken and the radiologist evaluated them with regards to hyperparathyroidism.
Results: In the 80 patients studied, prevalence of hyperparathyroidism was 45% (36 patients). 44 patients were diabetics. Among different factors, hyperparathyroidism did not correlate with frequency and duration of dialysis, age, sex ,familial history, diabetes, hypertension , bone pains, muscle weakness, purities and level of calcium and phosphorous. But there was a significant relationship between hyperparathyroidism and alkaline phosphatase levels and radiological findings.
Conclusion: We can use alkaline phosphatase levels and/or radiographic changes for evaluation of renal osteodystrophy in hemodialysis patients and prevent complications by early diagnosis and proper management.
Mk Amirbaigy, R Sami,
Volume 15, Issue 2 (Summer 2007)
Abstract
Pneumatosis cystoides intestinalis (PCI) is a rare condition charachterized by the presence of multiple gases filled cysts in the gastro intestinal tract. In this article we present three cases with different features, Who at the end evaluation PCI was diagnosed. The first patient present with rectorrhagia (submucosal PCI). The second patient present with dyspepsia (subserosal intestinal PCI) and the third patient present with gastric outlet obstruction (subserosal gastric & intestinal PCI).
Hr Sami Magham, A Negahi, A Haghighi, R Fayaz, E Booshehri,
Volume 15, Issue 3 (Autumn 2007)
Abstract
Introduction: Arteriovenous fistulas (AVF) make chronic hemodialysis easy, but the complications are unpredictable. Ischemic neuropathy due to arterial insufficiency is one of the most important complications of AVF. This study was designed to evaluate ischemic neuropathy using electro diagnostic method in the extremity carrying fistula.
Methods: In this cross-sectional study, 37 hemodialysis patients at the hemodialysis center of Shahid-Mohammadi hospital (Bandar-Abbas) were enrolled. All of the patients had only one AVF in one extremity. NCV of median and ulnar nerves of both upper extremities were evaluated and the intact extremity of all patients served as the control group.
Results: In patients with distal AVF, ulnar motor conduction velocities were significantly increased (p: 0.034). Distal and proximal amplitudes of ulnar nerve were decreased only in non-diabetic and hypertensive patients (p<0.05). Median sensory nerve action potential was increased, distal amplitude decreased (p: 0.04) and sensory latency was increased (p: 0.02). In patients with proximal AVF, ulnar proximal amplitude and median motor conduction velocities were decreased (p: 0.05). There was a negative correlation between the age of AVF and development of neuropathy. In most patients with neuropathy, AVF age was less than
one year.
Conclusion: Ulnar nerve is more sensitive to ischemia than median nerve and sensory fibers are more sensitive than motor fibers. The site of fistula had no affect on the rate of development of ischemic neuropathy. We recommend using electrodiagnostic study for screening of ischemic neuropathy every 6 months in hemodialysis patients.
A Mirabzadah, P Pakdel, K Khoshabi, Mr Khodaei, G Feiz-Zadeh, M Samiei,
Volume 17, Issue 3 (summer 2009)
Abstract
Introduction: The purpose of this study was to assess prevalence and possible variables on the change of diagnosis in mood disorder patients to schizophrenia.
Methods: This study was a retrospective and comparative analytic research that was performed in 2006 at Razi psychiatric hospital. The study included all of the 176 patients who were hospitalized in 2000 with diagnosis of a mood disorder. The patients were divided into two subgroups the stable group with a persistent mood disorder diagnosis and the changed group with a changed mood disorder diagnosis to schizophrenia. Data was analyzed by statistical chi-square and t student test.
Results: Findings showed that 31.3% of all of the patients shifted toward schizophrenia. 23.3% and 32.9% of patients with major depressive disorders and bipolar disorders shifted toward schizophrenia, respectively. There was no statistical difference between groups in demographic variables, but there was statistical difference in some of the clinical variables such as psychotic features (Pvalue=0.001), severe clinical features (Pvalue=0.016), and gradual onset of disorder (Pvalue=0.027) with change of diagnosis to schizophrenia.
Conclusion: Recognition of clinical variables associated with change of diagnosis to schizophrenia such as psychotic features, severe clinical features and gradual onset of disorder will help clinicians in better management of these patients than the past.
M Rouzrokh, A Jalali, M Samsami, H Zirakzadeh, A Heidari, M Fallah, Z Yekta,
Volume 19, Issue 3 (Jul-Aug 2011 2011)
Abstract
Introduction: Hirschsprung's disease(HD) is a common congenital disease. In 80% of cases, the recto sigmoid junction is involved. Recently, one-stage transanal endorectal pull-through(TAEPT) procedure has been popular, but it could have several complications. In this research, we have studied the complications of this procedure.
Methods: During a four year period, 86 infants clinically suspected to have HD were admitted at our center. HD was confirmed by rectal biopsy and all were candidates for TAEPT operation. A Swenson-like procedure was performed and in 30 cases, prophylactic Hegar dilatation was done 2 weeks after operation.
Results: Anal stricture was seen in 12 cases(14%) of which 10 cases were treated by anal dilation and 2 cases were corrected by surgical management. Entrocolitis was seen in 4 cases(5%) who were treated by medical management. In 2 cases, retrocolic abscess was present that was treated by spontaneous drainage via tube drain. There was no anastomotic stricture after starting prophylactic anal bouginage.
Conclusion: TAEPT has many advantages and few complications. It seems that one of the most common complications is anastomotic stricture that responds well to prophylactic bouginage. We recommend prophylactic anal bouginage with Hegar probe 2 weeks after operation. A long-term follow-up is needed to evaluate the outcomes of these operations.
L Yekefallah, Aa Vaezi, M Pazokian, F Yekefallah, F Samieefard,
Volume 20, Issue 3 (Jul-Aug 2012)
Abstract
Introduction: Numerous studies showed that lifestyle in the years of growth and adolescence is the most important factor in determining the risk of osteoporosis in later years of life. This study aimed to assess lifestyle and nutritional preventive behaviors of osteoporosis among teenagers in Qazvin in Iran.
Methods: This descriptive-analytical study was performed within teenagers, in a population – based sample of 300 students collected via random cluster sampling. Data was collected through a self-administered questionnaire containing 15 questions (Questions items included risk factors related to osteoporosis, preventive behaviors of osteoporosis, and demographic factors). Using SPSS 16, the data were analyzed by Chi-square and Fisher's exact tests.
Results: Findings showed that the majority of teenagers (71.3%) do not have regular physical activity. There were significant differences between physical activity patterns of male students and female students (P=0.001). Nutritional habit results showed that female students (66.7%) used foods (34.7%) containing vitamin D more than male students. The results showed that 29.3% of male students and 24.3% of female students didn’t use any calcium absorption increasing ways in the body.
Conclusion: The study findings show that osteoporosis in Iranian teenagers appears to correlate with several known risk factors and unsuitable behaviors that were well described in the literature. It revealed that preventive educational strategies on osteoporosis are important in this population. So modifying lifestyle among teenagers seems essential in order to prevent osteoporosis in the future
M Kalhor , F Samieerad , M Garshasbi , Z Mohitabadi , S Sefollah ,
Volume 24, Issue 5 (Aug 2016)
Abstract
Introduction: Involving the parents in caring of premature newborns is one of the best and effective manners for preventing the hospitalization of premature newborns. The present study aimed to evaluate the effect of mother – baby skin- to- skin care on neonatal outcomes in preterm infants, in Kosar hospital.
Methods: This was a descriptive comparative study conducted on 400 nulliparous women with premature infants admitted to neonatal intensive care unit of Kosar hospital during April 2012 and March 2015. Sampling was performed via convenience sampling. Sample population divided into two groups, one of them 200, the kangaroo care and non- care groups. The data were obtained by a researcher prepared check list, including mother’s demographic characteristics and neonatal outcomes. Both descriptive and statistical analysis methods were applied. For analyzing the data, chi-square test, t-test, and logistic regression tests was applied (P <0.05).
Results: The results showed that neonatal outcomes such as birth weight, frequency of breastfeeding, length of hospitalization of infants, re-admission, needing incubator and oxygen aid, hospital acquired infections, jaundice and hypoglycemia were significantly lower in the intervention group (P<0.05). But the incidence of intraventricular hemorrhage and neonatal respiratory distress syndrome in participants between the two groups were not statistically significant (P >0.05). In the intervention group, the relationship between maternal variables and neonatal outcome was significant (P <0.05).
Conclusion: Mother – baby skin- to- skin care has a positive effect on neonatal outcomes. Thus, supporting and awareness of premature infants’ mothers in order to implement this type of care can reduce the neonatal complications. Moreover, it is effective in decreasing the treatment costs.
A Dehdgan, Mr Mirjalily, Mh Zare Mehrjardi, M Raghebian, A Samiyezargar, Sk Kazemeini,
Volume 24, Issue 10 (Jan 2017)
Abstract
Introduction: Given the importance of increasing the percentage of natural childbirth , Ministry of Health and Medical Education of Iran decided to reduce the rate of caesarean. In line with this, guidelines of promoting the vaginal delivery programs were designed in order to increase the amount of natural childbirth in the university centers and reduce the cesarean rate by 10 percent by the end of 2014 in the context of healthcare reform programs. Therefore, this study aimed to evaluate the epidemiology of caesarean sections performed in academic and non-academic hospitals in Yazd between 2013 and 2014
Methods: This was a descriptive and analytical study. 56050 deliveries were carried out in academic and non-academic hospitals during the years 2013 and 2014. The census information collected and analyzed using SPSS 20. . To analyze the data, frequency and percentage descriptive statistics were used.
Results: Cesarean rate in 2014 was 47.37% in all of hospitals in Yazd and this rate was significantly higher in non-academic hospitals than academic ones. The rates of cesarean section in2014 were significantly decreased compared with 2013 in all non-academic and academic hospitals.
Conclusion: Finally, this study showed that healthcare reform plan and planning for the use of this procedure in certain cases can reduce the amount of unnecessary caesarean sections and possible side effects.
Fatemeh Samiee Rad , Hassan Jahani Hashemi , Mohammad Sofiabadi , Hamidreza Bahrami ,
Volume 25, Issue 7 (oct 2017)
Abstract
Introduction: Preeclampsia is one of the most common complications in pregnancy and a main cause of death in the perinatal period. The early diagnosis of severe disease form is important. The aim of this study was to evaluate the relationship between the serum high sensitive C - reactive protein (hs-CRP) and severity of preeclampsia.
Methods: This cross-sectional study conducted between 2013 October -2014 February in third trimester pregnant women that had been admitted to Qazvin Kosar Hospital they were divided into three groups as: the first included 50 healthy pregnant women (control), the second included 45 women with mild preeclampsia and the third group included 42 women with severe pre-eclampsia. Blood pressure was measured after at least 10 minutes resting in a sitting position. Blood samples were taken six hours after admission and the hs-CRP measured by immunoturbidometric method using bionic kit. Data were analyzed using ANOVA, x2 and Kruskal-Wallis tests.
Results: The average serum levels of hs-CRP were 2.4 in the control, 8.7 in the mild and 32.6 in the severe preeclampsia groups and this difference were significant in all the three groups.
Conclusion: According to the results, it seems that the serum levels of hs-CRP can be used in the prediction and diagnosis of the severity of preeclampsia.
Ebrahim Banitalebi, Majid Mardaniyan Ghahfarrokhi, Mohammad Faramarzi, Samira Nasiri,
Volume 26, Issue 3 (Jun 2018)
Abstract
Introduction: Fatty liver is a condition in people with type 2 diabetes mellitus (T2DM). The purpose of this study is to examine the effects of combined training on novel hepatic steatosis indices (fatty liver index (FLI), accumulation product (LAP), hepatic steatosis index (HSI), and Framingham steatosis index (FSI)) in women with type 2 diabetes.
Methods: 35 female with type 2 diabetes were assigned to combined training (n = 17) and control (n = 18). Intervention consisted of combined (aerobic-strength training) for 10 weeks. Data were analyzed using dependent t test to compare pretest and posttest in each group. The Analysis of covariance (ANCOVA) was used to compare the amount of changes in experimental and control training groups after 10 weeks.
Results: The results of the analysis of covariance showed that 10 weeks of combined training caused a non-significant decrease in HSI (P = 0.596), FSI (P = 0.312), FLI (P = 0.327) and a significant decrease in LAP (P = 0.334) compared to the control group.
Conclusion: The results show that 10-week combined training results in a significant decrease in LAP index and a non-significant reduction in FSI, HSI, and FLI indices of women with type 2 diabetes. Therefore, combined training recommended for improve the fatty liver in women with type 2 diabetes.
Bibi Fatemeh Haghiralsadat, Ghasem Amoabediny, Samira Naderinezhad, Farzane Morteza-Ratki, Behrouz Zandieh Doulabi,
Volume 26, Issue 12 (Mar 2018)
Abstract
Introdution: Cationic liposomes have been presented for gene delivery as an alternative vector instead of viral vectors. A major challenge associated with siRNA delivery is the instability of liposomes, which is still a serious problem. The aim of this study was to provide an appropriate formulation to overcome this instability.
Methods: In the present study (Scientific-Fundamental, Experimental-Laboratory Study), liposomal formulation containing soy phosphatidylcholine, cationic DOTAP, cholesterol and polyethylene glycole was synthesized by thin-film hydration method and the siRNA were loaded on liposomes through incubation. In the following; the optimization of siRNA loading was on the agenda. Then the parameters related to size, zeta potential, polydispersity index and lon-term stability of siRNA-liposomes complex were reported. The Data were analyzed by GraphPad Prism version 7 Software. All data were repeated three times and reported as mean±standard deviation.
Results: In this study we were able to produce siRNA lipoplex with high loading efficiency of siRNA. The produced nanoparticles did not agglomerate and were stable at 4 oC for 3 months. This nanosystem could successfully deliver siRNA to normal bone cells. Studies have shown that the blank system (no gene) had no toxicity.
Conclusion: The prepared PEGylated liposomes have a great potential for delivery of siRNA to bone cells
Nasrin Majidi Gharenaz, Mansoureh Movahedin, Samiyeh Majidi, Zohreh Mazaheri,
Volume 28, Issue 7 (10-2020)
Abstract
Introduction: Induction of in vitro spermatogenesis can be useful for infertility treatment in azoospermic patients and those undergoing chemotherapy. Different culture systems have been used to achieve this goal. This review study was performed with the aim to evaluate the application of 3D culture and testicular scaffolds in the establishment of in vitro spermatogenesis.
In this review study, the information on the application of 3D culture and testicular scaffolds in induction of in vitro spermatogenesis was searched in databases such as SID, Magiran, PubMed, Irandoc, Iranmedx Scopus, Google Scholar, Web of Science using the keywords of three dimensional culture, testicular scaffold, spermatogenesis, spermatogonial stem cells without time limitation. Data analysis was carried out qualitatively. Finally, 35 papers in English and Persian were used to compile the article.
In order to induce of in vitro spermatogenesis, three-dimensional culture methods such as testicular tissue culture, soft agar culture system, natural biomaterial scaffolds such as collagen, and scaffolds derived from decellularized testis have been used.
Conclusion: Three-dimensional culture using spermatogonial stem cells and scaffolds can be used in vitro for induction of spermatogenesis, but there are further technical and ethical challenges in the path of fertile sperm production for the treatment of infertility.
Reza Nafisi Moghadam, Mehrdad Mansouri, Seyed Kazem Razavi, Nasim Namiranian, Mohammad Sobhan, Samira Sarhadi,
Volume 29, Issue 4 (7-2021)
Abstract
Introduction: Minor head trauma is one of the common causes of pediatric reference to emergency ward. This study investigated the correlation between scalp hematoma,cranial fractures and intracranial lesions in children presenting with minor head traumata.
Methods: This was a descriptive cross-sectional study. The data gathering were done in 2016-17. All children under 18 years of age (933 individuals) who referred to Shahid Rahnemoun Pediatric Emergency Center in Yazd with a complaint of minor head trauma and underwent a CT scan according to American Academy Criteria were included in the study. The mean age of the children was 11.67 years. CT scan of 209 patients (%22.41) reported scalp hematoma. A radiologist who did not have any information about the study was asked to interpret the CT scans using a predesigned checklist. Finally, the data were encoded into an Excel file and statistically analyzed by STATA10 software using Chi-square test and logistic regression.
Results: The scalp hematoma was significantly related to intraventricular hemorrhage (P<0.001), subarachnoid hemorrhage (P<0.001), intracerebral hemorrhage (P<0.001), cerebral edema (P<0.001), subepidural hemorrhage (P<0.001), cerebral concussion (P<0.001), cerebral shift (P<0.001), pneumocephalus (P<0.001), and cranial fracture (P<0.001); however, scalp hematoma was not significantly related to diffuse axonal injury (P=0.27).
Conclusion: Our findings confirmed the importance of presence of scalp hematoma in clinical assessment of children with minor head trauma aged less than 18 years. It is recommended that children with minor head trauma be treated and evaluated more in the emergency department more vigilantly and meticulously.
Samira Hajimaghsoodi, Ozra Mohiti , Shadi Paknejad,
Volume 29, Issue 10 (1-2022)
Abstract
Introduction: Dental profession has an ethical and legal responsibility in patient care. A properly maintained patient record is a very important aspect of this patient care. The aim of this study was to evaluate dentists' practice in obtaining and recording the medical and pharmacological history of patients in Yazd City in 2020.
Methods: In this descriptive cross-sectional study, 197 dentists working in Yazd City were selected during the study and their practice in obtaining and recording medical history was evaluated using a valid questionnaire. Data were analyzed by SPSS16 statistical software t-test and Pearson correlation coefficient.
Results: Out of 197 dentists participating in this study, 93 (52.8%) were male and 104 (47.2%) were female. Their mean age was 39.37± 8.36 years and their mean clinical experience was 6.5± 9.25 years. The mean score of dentists' practice in obtaining and recording the medical and pharmacological history was 61.30±4.95 (range 45-72) out of 72 points. There was no statistically significant difference between the mean score of dentists' practice by gender, clinical experience, university of study and degree (P-value>0.05), but there was a statistically significant relationship between dentists' age and their practice score (P-value=0.040).
Conclusion: Based on the results of the present study, the mean practice source of dentists in obtaining and recording the medical and pharmacological history of patients was good. The effect of gender, university of study and degree on dentists' practice was not significant. However, with increasing age and experience in dentistry, the practice score of dentists was lower.
Samira Hajimaghsoodi, Mohammadhasan Akhavankarbasi, Rezvan Bagheridokht,
Volume 30, Issue 3 (6-2022)
Abstract
Introduction: Fear of dentistry causes problems for the patient and the dentist and can reduce the pain threshold, use fewer services or avoid treatment. The aim of this study was to investigate fear of obtaining dental services and related causes in medical students of Shahid SadoughiUniversity of Medical Sciences inYazd City in 2020.
Methods: 191 students participated in this descriptive-analytical study. The dental fear survey (DFS) and a questionnaire to assess the causes of dental fear were used. Data were analyzed by SPSS 16 software, ANOVA and T-tests.
Results: The results showed that dental students had the lowest level of fear and nursing students had the highest level of fear. Fear of dentistry was higher in women than men and the average fear score decreased among the students in higher semesters (fifth semester students) (P<0/05). Fear of dentistry was related to some factors such as economic status, oral health, history of anxiety disorders and the time since the last visit (P = 0.001). The most common factors influencing this fear were corona fear, dental work with pain, needle fear, price fear, and turbine fear.
Conclusion: Fear of obtaining dental services was influenced by major, gender, semester, time since the last visit to the dentist, history of anxiety disorders, economic status and oral hygiene among medical students, but marital status had no effect on the level of fear.
Mohammad Hadi Samiei, Shahla Jamili, Habib Nikukar, Vahid Razban,
Volume 30, Issue 6 (9-2022)
Abstract
Introduction: Collagen bears many applications in pharmacy and medicine, health and cosmetic products as well as food industry. In recent years, much attention has been paid to separation of collagen from marine organisms arising from the fact that its use in the diet is not restricted and triggers no risk of contagious diseases as well as religious restrictions. Moreover, fish collagen is unique in terms of its extremely high solubility in dilute acid on a scale with mammalian and chicken collagen. The purpose of this study was to investigate the isolation and evaluation of collagen from fish skin (Thunnus tonggol) as a biological material for medical tissue engineering.
Methods: Acid-soluble collagen (ASC) was isolated from fish skin using acetic acid. The Thunnus tonggol skin collagen was extracted by acid and base methods and evaluated by PAGE-SDS, FTIR and UV spectrophotography and amino acid composition analysis.
Results: The results, predicated on SDS-PAGE and amino acid compositions, demonstrated that the fish skin collagen is of type I. Fourier transform infrared analysis also revealed helical compositions of both collagens. UV spectrophotometry in the Thunnus tonggol skin collagen indicated a maximum absorption of 235 nm. The amount of collagen extracted from the Thunnus tonggol skin turned out to be 17.3%. Through analysis of collagen amino acid extracted from the mentioned fish, glycine was predominant. The growth and proliferation of human fibroblast cells on the collagen extracted from the Thunnus tonggol skin was more than control.
Conclusion: The results revealed that the fish collagen is an accessible and advantageous material for medical usage and tissue engineering.
Samira Mozaffari Khosravi, Saman Seyedabadi, Seyed Hossein Shahcheraghi, Marzieh Lotfi,
Volume 32, Issue 2 (5-2024)
Abstract
Introduction: Women of reproductive age may encounter challenges related to infertility or miscarriage, due to conditions such as premature ovarian failure (POF). POF, affecting approximately one percent of women under the age of 40, can lead to infertility. Current data have suggested that utilizing stem cell therapy was the most effective approach for treating POF compared to alternative options. Among the various stem cell types, mesenchymal stem cells derived from the umbilical cord (HUC-MSCs) was a promising choice for treatment due to its features such as relatively low immunogenicity, multipotent, multiple origins, cost-effectiveness, ease of production, and high efficiency.
Conclusion: One of the ways to treat POF is the use of mesenchymal stem cells derived from the umbilical cord, these cells have an extraordinary capacity for repair and regeneration, which helps them in repairing depleted ovaries. The results of this review article indicate that the use of HUC-MSCs can be considered as a potential treatment method in these patients.
