Showing 6 results for Ramezani
J Baharara, M Mousavi, T Ramezani,
Volume 22, Issue 3 (Jul- Aug 2014)
Abstract
Introduction: Tumeric is a plant with both food and medical properties by which Curcumin is derived from. It has various pharmacological effects. Angiogenesis, a dynamic process of endothelial cells proliferation in order to develop new blood vessels from the previous ones, affects a wide range of physiological and pathological processes such as tumor growth and metastasis. In this study, anti angiogenic effects of Cucumin were investigated in aortic ring of Wistar rats.
Methods: In this experimental study, Aortic ring was cut up in to 1 mm pieces and cultured in collagen matrix. After three days, sprouting angiogenesis were observed, and then aortic rings were treated with Curcumin at concentration of 25, 50 and 100 µg/ml. Effects of treatment in all cases were photographed and then investigated by invert microscope. Lengths of vessels were measured by Image J software. Moreover, the study data were analyzed using SPSS in significant level of P<0.05.
Result: Data analysis revealed that no significant difference was observed in regard with average of length and number of blood vessels in the control group compared with sham-exposed group (P>0.05).In fact, average length and number of blood vessels in experimental group 1 demonstrated no significant difference compared with control group, though in the experimental group 2 (79.45±3.2mm), (12±1.3) and 3 (38.93±1.1mm), (8±1.1) significant differences were observed (P<0.05(.
Conclusion: The results proposed that the Curcumin had dose-dependent inhibitory effects on angiogenesis in rat aortic ring Therefore, it can be introduced as an appropriate candidate in order to study angiogenesis and related diseases.
J Baharara, M Motie, T Ramezani, Ar Iranbakhsh,
Volume 24, Issue 4 (Jul 2016)
Abstract
Background and purpose: Angiogenesis has a role in many vital processes also many developmental processes are influenced by an electromagnetic field. In the present study the synergic effects of silver nanoparticles and low-frequency electromagnetic field on angiogenesis in the chick embryo chorioallantoic membrane (CAM).
Materials and method: In this experimental study, (Ross strain ) on the eighth day incubation of embryonated chicken eggs were treated with 50, 100 and 200 mg/ml of silver nanoparticles. Then on tenth day, the eggs for 3 hours were exposed to the electromagnetic field. The twelfth day, the samples were photographed and the number, length of vessels, weight and Crown-rump were analyzed with software Image J. hemoglobin content were tested with derabkin assay. Silver nanoparticles antioxidant activity was assessment. Data were analyzed using spss 16 software and ANOVA statistical test.
Results: The average number and length of vessels and hemoglobin content decreased in treated groups with silver nanoparticles and Electromagnetic fields. synergic use of silver nanoparticles and Electromagnetic fields reduce the average number and length of vessels and hemoglobin content than using one alone. Antioxidant assay showed that silver nanoparticles inhibited free radical production.
Conclusions: Synergic application of biogenic silver nanoparticles with electromagnetic field significantly reduced angiogenesis CAM comparing to use one of them.
M Ramezani Moghadam, N Heydarieh, M Khoshsokhan,
Volume 24, Issue 5 (Aug 2016)
Abstract
Introduction: Depression is one of the most common mental disorders, which its effective treatment maintains an acceptable level of performance in patients. Concerning the different effects of sexual glands on various physiological phenomena such as depression, the purpose of this study was investigation of the effect of Atorvastatin on depression by forced swimming stress model in gonadectomized male mice.
Methods: 24 male rats with an average weight of 30-35 g were used in the study. Rats were randomly divided into 3 groups (n=8). Those groups included a group which was not gonadectomized, the gonadectomized group received DMSO and gonadectomized group received Atorvastatin. At first, mice were gonadectomized. One week after the operation, treatments were administered intraperitoneally half an hour before the test. Depression was assessed by the forced swimming test. In this test, mice were placed into a cylindrical glass (25 cm height, 12 cm in diameter) containing a column of 8 cm of water at 25±1°C. In 10 minutes, the number of immobile, swimming and climbing wall were recorded. The data were analyzed by one way variance analysis and Tukey’s test using SPSS.
Results: Intraperitoneal injection of Atorvastatin (40 mg/kg) significantly increased the immobility time in the gonadectomized mice taking the drug or solvent DMSO in forced swimming test. The gonadectomy had an increase in depression compared to healthy mice (p<0.05).
Conclusion: The findings of the present study indicated that taking Atorvastatin having a two-folded increase in depression of gonadectomized mice.
Alireza Ramezani, Yaghoub Mehrialvar , Abaas Ali Gaiini , Fereshte Golab, Riaz Kheratmand,
Volume 26, Issue 2 (May 2018)
Abstract
Introdution: This study aimed to investigate the effect of a period of high-intensity interval training on regulation signaling of factors involved in vascular changes following myocardial ischemia.
Methods: 28 rats (200-250 g) were randomly assigned into four groups of sham, ischemia, training, and training-ischemia in this study. Myocardial infarction was performed by closing descending coronary artery for 30 minutes. The training program on treadmill was performed for 40 minutes, 3 days a week, for 8 weeks. SPSS software (21) and one way ANOVA were used for statistical analysis. Also, Bonferron's post hoc test was used to determine the difference between groups.
Results: The results showed a significant difference in expression level of HIF-1, AKT, VEGF, apelin, and apelin receptor between the 4 groups (p = 0.001). The results of Bonferroni post hoc test showed that expression level of VEGF, apelin, and apelin receptor in training-ischemia group was significantly increased compared to sham, ischemia and exercise training groups. The results also showed that there was no difference between interval training group and myocardial ischemia and sham groups (p > 0.05). High-intensity interval training during an ischemic intervention increased AKT expression level, but exercise training itself did not make this change (p > 0.05). HIF1-a expression level was significantly increased in ischemia group compared to sham and exercise training groups.
Conclusion: HIIT training improves signaling of the factors involved in vascular changes (molecular) and ultimately reduces myocardial infarction size (tissue) following myocardial ischemia.
Zahra Soltanian, Behnaz Vanaky, Nasrin Ramezani Fard, Nader Shakeri, Zahra Shams, Fatimah Fakhari Rad ,
Volume 27, Issue 6 (10-2019)
Abstract
Introduction: Type 2 diabetes has many complications, including cardiovascular disease, which is associated with an increase in inflammatory biomarkers. Research has shown that physical activity can reduce inflammatory factors and improve cardiovascular disease. The purpose of this study was to investigate the effect of resistance exercise on some of the inflammatory and anti-inflammatory factors in the heart tissue of type 2 diabetic rats.
Methods: In this study, 18 male rats were selected. Rats were diabetic with nicotinamide and streptozotocin (stz) and then randomly divided into 2 groups of control (n=9) and training (n=9). The training group performed a resistance training program for 8 weeks, 5 days a week. Measurement of TNF-α and IL10 expression in the heart tissue was determined using the one step SYBR TAKARA single-step kit. To compare the difference between the mean of variables between exercise and control groups, independent t-test and t-test were used also to determine the effect of diabetes induction on variables. To determine the relationship between variables, Pearson correlation coefficient and separation correlation coefficient were used. Data were analyzed by SPSS software version 22.
Results: The results showed that the insulin resistance index decreased significantly in the training group compared to the control group. On the other hand, the expression of TNF-α gene decreased and IL10 showed a significant increase (α≤0.05).
Conclusion: The results indicate that resistance training may be effective in modulating the inflammatory factors of TNF-α and IL10 in the heart tissue of type 2 diabetic rats.
Mohsen Nabi Meybodi, Neda Arbab Tafti, Vahid Ramezani, Mahsa Tavakolian Ardakani, Maryam Akrami, Ali Mohammad Ranjbar Jamal Abadi ,
Volume 28, Issue 10 (12-2020)
Abstract
Introduction: Herbal medicines are one of the most widely used complementary therapies in the world. Therefore, it is necessary to perform exact studies on the status of herbal medicines in communities. The aim of this study was surveying the prescription amount of herbal medicines prescribed by physicians and the effect of variables such as gender, degree of education, age, type of specialization of physicians, different seasons, source of drug production, price and the rate of insurance coverage on it.
Methods: The current study was a descriptive-analytical and cross-sectional one. This research was conducted in the period of April 1 to March 20, 2016 in a public pharmacy in Yazd. 1824 prescriptions were obtained using Cochran's statistical formula and the amount of prescription containing herbal medicines was evaluated using the prepared lists. The collected data in three general categories, including physicians' demographic characteristics, prescriptions and their containing drugs specification were analyzed using SPSS (version 16) software and using the Chi-square statistical test.
Results: Among the 1824 prescription examined, only 120 prescriptions contained herbal medicines with the average number of 1.05 ± 0.22 herbal medicine items in each prescription. 114 prescriptions (95%) and 6 prescriptions (5%) included one and two herbal items, respectively. There was a significant relationship between the amount of herbal medicine and the degree (P=0.041), type of specialization (P=0.04) and gender of the doctors (P=0.009), however, there was no significant relationship between the amount of prescription containing herbal medicines, the seasons of prescription (P=0.866) and the age of the physicians (P=0.089).
Conclusion: Considering the results of this study, the amount of herbal medicines prescribed by physician in Yazd city is low.
