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Showing 4 results for Nasirzadeh
Effect of Methanol Soy Extracts on TSH, T3and T4 Serum Concentrations in Ovariectomized Rats
Mr Nasirzadeh, Ar Karamibonari,
Volume 21, Issue 6 (Jan-Feb 2014)
Abstract
Introduction: Foods including soy and dietary supplements are widely used for health benefits, particularly by menopausal women. Serum levels of T3 and T4 decrease in ovariectomized animals and on the other hand, Estradiol can increase levels of thyroid hormones. Therefore, the aim of this study was to examine the effects of soy extract on the thyroid hormones in ovariectomized rats. Methods: Forty female wistar rats were randomly divided into four groups (ten animals in each): Sham–operated (surgery without remove of ovaries), ovariectomized, treated (OVX+soy extract) and control-gavages (intact animals with soy extract). Animals in sham - operated and ovariectomized (OVX) groups received 0/5 ml normal saline by gavages. Animals of treated and control-gavages groups were treated with soy extracts 60mg/kg/day in drinking water for 28 days by gavages. Results: The results showed that TSH serum level increased and serum levels of T3 and T4 decreased significantly in OVX group compared to the sham group (p0.000). Furthurmore, serum levels of T3 and T4 increased and TSH levels decreased significantly in the treated group compared to the OVX group (p0.000). Conclusions: Soy extract administration has a positive effect on serum concentrations of thyroid hormones in ovariectomized rats.
Oleuropein cardioprotection effect against oxidative stress in Streptozotocin-induced diabetic male rats
Shahin Kashefimehr, Mohammadreza Nasirzadeh,
Volume 27, Issue 3 (7-2019)
Abstract 
Introdution: Diabetes is the most common endocrine disorder characterized by hyperglycemia. Increasing the oxidative stress and changing the amount of antioxidants play important roles in pathogenesis of diabetes. Nowadays to control diabetes and its complications, the use of herbal drugs is considered widely. In this study, we investigated the effect of oleuropein on antioxidant enzymes activity of heart tissue in Streptozotocin induced diabetic male rats.
Methods: In this study, 30 adult male Wistar rats with a weight range of 190±30 gr were randomly divided into 3 groups(n=10 in each group): 1) control group or intact rats, 2) diabetic rats, and 3) treatment group, which received 60 mg/kg oleuropein for 30 days by gastric gavage. Diabetes was induced by injection of streptozotocin (60 mg/kg) intraperitoneally. At the end of the treatment, serum concentrations of blood glucose and heart tissue antioxidant enzymes activity were determined. The obtained data were analyzed using  SPSS Inc., Chicago, IL; Version 18, statistical method of one way variance analysis and post hoc-Duncan test .
Results: The results showed that serum concentration of glucose decrease significantly in treatment group compared with the diabetic group (p=0.000). Also, TAC, SOD and GPX activity increased significantly in the treatment group compared with the diabetic group (p=0.000).
Conclusion: This study showed that oleuropein can prevent blood glucose increasing and reinforce antioxidant system of cardiac tissue in diabetic rats.

Comparison of Glucose and Immunoglobulin a Levels in Serum and Saliva of Patients with Type 1 and Type 2 Diabetes
Amirreza Nasirzadeh, Reza Khorammakan, Saeed Erfanpoor, Jafar Hajavi,
Volume 32, Issue 6 (9-2024)
Abstract
Introduction: The monitoring and management of blood glucose levels are of significant importance in individuals diagnosed with diabetes mellitus. Accordingly, the objective of this study was to examine the potential of a non-invasive approach for the diagnosis and management of diabetes, through the measurement of glucose concentration and salivary IgA, and a comparison with fasting glucose and serum IgA levels in individuals with type 1 and 2 diabetes, in relation to a control group of healthy individuals.
Methods: This case-control study was conducted on 76 individuals with diabetes (31 with type 1 diabetes and 45 with type 2 diabetes) and 24 healthy individuals. After obtaining the code of ethics and informed consent, serum and salivary IgA levels as well as fasting glucose, were measured for each participant. The data were analyzed using SPSS version 16 statistical software and the Spearman, Kruskal-Wallis, and Mann-Whitney tests.
Results: The results showed a significant difference among the three groups (type 1 diabetes, type 2 diabetes, and healthy group) based on Fasting Blood Glucose, Hemoglobin A1c, Immunoglobulin A, salivary sugar, and salivary IgA (p<0.001). Additionally, in the case group, parameters such as FBS, HbA1c, and salivary IgA showed a significant correlation with salivary sugar. Conversely, in the control group, only the salivary sugar level demonstrated a significant relationship with serum glucose level. The study's findings indicated that serum and salivary IgA levels were lower and higher, respectively, in the control subjects compared to the diabetic group (p<0.001).
Conclusion: In healthy individuals, salivary sugar can serve as an indicator to determine fasting blood sugar levels. In diabetic patients, salivary sugar can predict of FBS, HbA1c, and salivary IgA levels.
 

Renal Protective Effect of Resveratrol against Vincristine-Induced Oxidative Stress in Female Mice
Mohammadreza Nasirzadeh, Mir Hadi Khayatnouri, Saeed Taginasab, Pouya Navidi Far, Mohammad Bakhshi, Heidar Tayefesattari,
Volume 32, Issue 11 (2-2025)
Abstract
Introduction: Vincristine (VIN) is a broad-spectrum anticancer drug used to treat various cancers. Resveratrol (Res) is a natural polyphenol found in numerous plant sources. Many studies have reported anti-inflammatory and antioxidative effects of resveratrol. In this study, the effect of resveratrol on kidney damage caused by vincristine in female mice has been investigated.
Methods: In this study, 36 female mice weighing 25-30 grams were randomly divided into four groups (n=9): 1) Control group, 2) Vin- group, 3) Vin-Res group and 4) Res group. The mice received vincristine at 3 mg/kg once a week for 4 weeks and resveratrol at 30 mg/kg daily for 28 days through gavage. At the end of the study, the fat peroxidation index (MDA), total antioxidant capacity (TAC), and the activities of the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPX) in kidney tissue were measured. Data were presented as mean ± standard deviation, and the significant differences among groups were analyzed using SPSS16, one-way ANOVA, and Tukey's post hoc test.
Results: The findings indicated that in the vincristine group, levels serum of urea, creatinine, and MDA in kidney tissue were increased significantly compared to the control group (P=0.001).the TAC level and the activity level of GPX (P=0.001) and SOD (P=0.009) enzymes in the kidney tissue were  significantly decreased in the vincristine group when compared to the control group (P=0.001). Conclusion: The results of this study showed that the protective effects of resveratrol were probably attributed to its antioxidant properties and that it could reduce the kidney damage induced by vincristine.
 

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