Showing 10 results for Hakimi
Mr Aminipour, A Barkhordari, Mh Ehrampoush, Am Hakimian,
Volume 16, Issue 2 (Summer 2008)
Abstract
Introduction: The extensive use of Lead has led to health problems including CNS, anemia and other occupational poisoning among workers. To determine the blood lead levels in relation to demographic factors, this study was carried out.
Methods: In this cross sectional study, 490 workers at Kooshk Lead and Zinc mine were selected and blood samples were taken. The blood lead levels were assessed according to the NIOSH standard using atomic absorption.
Results: The mean, minimum and maximum of blood lead levels were 49, 9 and 116 mg/dl, respectively. The blood lead levels in 45.7 percent of workers was more than permissible limit. The blood lead level was not significantly related to age and history of work. The lowest and highest levels of blood lead were 9 & 116 mg/dl, respectively. In contrast, significant relationship was seen between the location of work and blood lead level. The results showed that in the majority of workers with blood lead levels higher than standard limit, there was a significant relationship between the blood Lead levels and the hemoglobin concentration. The blood lead level in 45% of samples was more than Iranian standards.
Conclusion: The work location was the main factor affecting the blood lead levels. Attention should therefore be focused on the alteration of RBC and Hemoglobin levels during periodic medical examination of workers
F Hokmollahi, H Rafati, H Riahi, M Hakimi, A Aliahmadi, H Heydari, F Haghirosadat, M Azimzade, S Mosazade,
Volume 18, Issue 6 (Jan- Feb 2011)
Abstract
Introduction: Macromycetes are considered as new resources for medicine with various biological properties. One of the most important medicinal fungi in Iran is Phellinus conchatus. This genus contains 359 species around the world of which 12 species are reported from the north regions of Iran. Phellinus species have anticancer, antioxidant and antibacterial effects. Moreover, they have been used in traditional medicines for treatment of several diseases. Due to the increasing bacterial resistance to existing antibiotics, it seems that research for new sources of antibiotics is necessary.
Methods: The purpose of this research was to collect and identify the species with respect to hosts, dispersal, macromorphological and micromorphological characters of the species, and their biological effect against Gram-negative bacteria and Gram-positive bacteria was evaluated using total methanol extract and it’s fractional extracts(chloroform, butanol and water extracts) using disk diffusion method, minimum inhibitory concentrations(MICs) and minimal bactericidal concentrations(MBCs).
Results: The results of disk diffusion tests showed that all extracts except aqueous extract had growth inhibitory effects on three bacteria Staphylococcus aureus, Bacillus cereus and Pseudomonas aeruginosa. The butanolic extract showed the best result in growth inhibition against the bacteria, especially on Pseudomonas aeruginosa . The MICs and MBCs of the butanol extract of these bacteria were(1, 2mg.disk), (2, 4 mg.disk) and(8, 16mg.disk), respectively.
Conclusion: The results show that different extracts, especially butanol extract have high antibacterial activities which indicate the presence of active components in this fraction. More fractionation studies are under way to isolate the antibacterial components in the butanolic extract.
V Ehsani, M Allahtavakoli, Mh Dashti, Me Rezvani, H Rezazadeh, A Shamsizadeh, M Mobini, E Hakimi,
Volume 21, Issue 6 (Jan-Feb 2014)
Abstract
Introduction: Hypothermia has neuroprotective effects in permanent or transient models of cerebral artery occlusion. In the current study, neuroprotective effect of general hypothermia in the embolic model of stroke, in which no study has been conducted to date.
Methods: In this experimental study, twenty-four male Wistar rats (250 to 350 g) were divided into three groups as following: sham, Control and hypothermia. Stroke was induced by clot injection into the right middle cerebral artery (MCA). General hypothermia was induced at 6 h after stroke. Neurological deficits were measured at 24 and 48 h after ischemia. Infarction volume and brain edema were determined at the end of study.
Results: General hypothermia significantly decreased infarct volume (P<0.001) and neurological deficits (P<0.001). No significant difference was observed between hypothermia and control group in brain edema.
Conclusion: According to the findings of the present study, general hypothermia at six h after ischemia shows neuroprotection in the embolic model of stroke.
M Hakimi, Sr Attarzade Hosseini ,
Volume 23, Issue 12 (Mar 2016)
Abstract
Introduction: Obesity is a metabolic disorder that is caused by increased energy intake and reduced energy expenditure. This study aimed to investigate the effect of eight weeks of aerobic training on Irisin serum levels and lipid profile of overweight male students.
Methods: In this quasi-experimental study, 24 overweight male students (age: 21.13±1.88 years and BMI: 25-29.9 kg/m2) were selected by purposeful and convenience sampling method, who were randomly assigned into control (n=12) and experimental (n=12) groups. The program involved training with 60-80 HRmax% for 3 sessions per week, 40-50 minutes per session lasting for 8 consecutive weeks. The control group, simultanonsly, continued their daily activities and did not participate in the aerobic exercise. Irisin serum levels and lipid profile of all subjects were measured before and after the training period. To make intra and intergroup comparisons, repeated measure analysis of variance was used, and the level of significance was set at P<0.05.
Results: Eight weeks of aerobic exercise led to a significant increase of Vo2max and HDL-C levels (P<0.05) as well as a significant decrease of weight, BMI, body fat percent and TC (P<0.05). In contrary, the variations of Irisin levels, Serum LDL-C, and TG did not demonstrate any significant changes (P>0.05).
Conclusion: Aerobic training, without making any changes in Irisin levels, can produce a positive effect on the increase of VO2max, improvement of body composition and decrease of lipid risk factors.
Najmeh Najafi, Habibollah Hosseini, Maryam Hatami, Mahmmod Vakili, Farzaneh Shishebor, Mohammad Zamanian, Elham Hakimizadeh,
Volume 26, Issue 3 (Jun 2018)
Abstract
Introduction: Post-operative pain reduction is one of the problems in the patients with preoperative narcotic dependency. Morphine is the most common drugs to control postoperative pain. Due to resistance to morphine and its side effects in addict patients, using of adjuvant drugs such as ketamine has increased. The aim of this study was to evaluate the effect of adding ketamine to morphine in patients addicted to opioid with post orthopedic operation pain.
Methods: In a double blind clinical trial, 60 patients undergoing orthopedic operation with history of opioid consumption were randomly divided in 2 groups. Post operation, the first group received morphine 20 mg and the second group received morphine 20 mg + ketamine 100 mg via IV patient-controlled analgesia (IPCA). The pain score as visual analogue scale (VAS), sedation score, and nausea and vomiting were evaluated at 1, 6, 12 and 24 hours post operation. SPSS v.20 was used for data analysis.
Results: Results showed that dose of morphine consumption in morphine group was significantly increased compared to the morphine + ketamine group (p ˂ 0.001). In addition, only at 12 hours after surgery the mean of pain score in the morphine group was significantly reduced compared to the second group (p = 0.02). The mean of sedation score at 1 (p ˂ 0.001), 6 (p = 0.002), 12 (p = 0.001) and 24 (p ˂ 0.001) hours after surgery in the morphine group was increased compared to the other group. At 1 hour, the mean of nausea and vomiting scores in the morphine group was significantly reduced compared to the morphine + ketamine group (p = 0.024).
Conclusion: Addition of ketamine to morphine in the patients with history of opioid consumption reduced using of the morphine. But had no effect on pain and sedation score reduction.
Mohammad Pak-Hashemi, Mahsa Hassanipour, Ayat Kaeidi, Pooya Saeed-Askari, Iman Fatemi, Mohammad Reza Rahmani, Elham Hakimizadeh, Jalal Hassanshahi, Vahid Ehsani, Zahra Taghipour, Marzieh Khademi, Mohammad Allahtavakoli,
Volume 28, Issue 3 (6-2020)
Abstract
Introduction: Aging is a complex process and is considered as a risk factor for many diseases such as hypertension, Alzheimer, cancer, depression and anxiety. Recently, it has been shown that metformin, an anti-diabetic drug, has important neurological effects such as preventing memory loss, stroke, anxiety, inflammation and seizures. Therefore, the aim of this study was investigating the effects of metformin on some cognitive factors in elderly male rats.
Methods: 24 rats (22 months) were randomly divided into 3 groups (n=8). The first group was the control group that received water orally, the second group received metformin 1 mg/kg orally and the third group received metformin 10 mg/kg orally. After treatment for 40 days (once daily), behavioral tests, including Y-maze, elevated plus maze and depression test were performed on animals. Results were analyzed using GraphPad Prism version 6 and One-way ANOVA followed by Tukey-post hoc test.
Results: The results of this study showed that metformin at a dose of 10 mg/kg significantly reduced anxiety (P<0.001) and depression (P<0.001) in older animals. Metformin at a dose of 1 mg/kg failed to improve aging-related disorders in this model.
Conclusion: Metformin at a dose of 10 mg/kg can reduce the quality of life by reducing anxiety and depression.
Sajjad Sattai Mokhtari, Elham Hakimizadeh, Mojdeh Haj Mohammadi, Ayat Kaeidi, Iman Fatemi, Mahsa Hassanipour, Jalal Hassanshahi, Mohammad Allahtavakoli,
Volume 28, Issue 11 (1-2021)
Abstract
Introduction: During menopause, which is a part of the aging process in women, the level of sex hormones decreases, which causes problems such as memory impairment and cognitive functions. One of the treatment options for these disorders is hormone therapy, which has several side effects. The present study investigated the effect of remote ischemic conditioning (RIC) technique on memory improvement, muscle strength, motor and balance function in ovariectomized rats.
Methods: In the present experimental study, 24 Wistar female rats with an approximate weight of (170-220 g) were divided into three groups (n = 8) including, 1: control group, 2: ovariectomy group and 3: ovariectomy+ treatment group. Initially, the animals in the second and third groups underwent ovariectomy surgery. The RIC techniques were performed on treatment group of rats for two months. After that, memory, muscle strength, and motor and balance function were assessed in all groups. SPSS software (V21) and one-way analysis of variance were used for statistical analysis.
Results: The result of this study showed that RIC technique significantly improved memory in the ovariectomy+treatment group in comparison with the ovariectomy group (P<0.04). The results of forced swim test showed that RIC technique significant increase muscle strength in the ovariectomy+treatment group compared to the ovariectomy group (P<0.0281).The result of motor and balance performance did not show any significant improvement.
Conclusion: RIC technique can have beneficial effects on menopausal-related disorders and ovariectomy.
Fateme Sadeghi Nodoushan, Fatemeh Hakimian, Bibi Fatemeh Haghiralsadat,
Volume 31, Issue 10 (1-2024)
Abstract
Introduction: Nanotechnology always seeks to provide new solutions for targeted delivery of chemotherapy drugs, in order to increase the quality of cancer treatment and reduce the side effects of chemotherapy. The aim of this study was to load the anticancer drug doxorubicin on Magnetic iron oxide nanoparticles were subjected to physico-chemical evaluation for their effect on MCF-7 cells.
Methods: This research was a descriptive-analytical study. In this laboratory research, iron oxide nanoparticles were first synthesized by precipitation method. Then they were coated with polyethylene imine and gold. After loading the drug doxorubicin into the magnetic iron oxide nanoparticles, the physiochemical parameters of the nanosystem from the point of view of insertion efficiency, drug release profile under similar conditions of healthy and cancer cells, size, zeta potential and morphology were determined.
Results: The magnetic nanocarriers had a diameter of 90 nm and a zeta potential of 66.7 mV. The maximum release of the drug from the nanosystem at 37°C, pH=7.4 and 42°C, pH=5.4 and after 48 hourswas 48% and 66%, respectively. The SEM analysis showed the spherical morphology and the absence of chemical interaction between the nanosystem and the drug. The investigation of the performance of the nanosystem indicated an increase in the toxicity of encapsulated doxorubicin compared to free doxorubicin at similar concentrations on the MCF_7 strain.
Conclusion: The results of this research showed that the magnetic iron oxide nanoparticle system, while having appropriate physiochemical characteristics, does not change the chemical nature of the drug and can be a suitable and semi-targeted carrier for the anticancer drug doxorubicin.
Fatemeh Mehravar, Mohammad Khodabakhsh, Hamed Salehi, Roqayeh Hakimian, Monireh Sadoughi,
Volume 32, Issue 5 (8-2024)
Abstract
Introduction: Due to the importance of preserving baby teeth, it is necessary for parents to have correct information about dental services for these teeth, the present study was conducted with the aim of investigating the acceptance of suggested treatments for baby teeth by parents.
Methods: In this descriptive-cross-sectional study, 218 parents of children under 12 years old who were referred to the Pediatric Dentistry Department of Yazd Faculty of Dentistry in 2022 were randomly included in this study. The acceptance rate of dental treatments was asked by a checklist with 7 comprehensive questions and the answers were recorded. Data were analyzed using SPSS version 16 and Chi-square statistical test.
Results: Out of 218 parents who participated in this study, 38 (17.4%) were male and 180 (82.6%) were female. The most acceptable treatments by parents were: pulp treatment (98.6%), dental radiographs (97.7%), tooth extraction (97.2%) and stainless-steel crowns (95%). The lowest rate of acceptance was for general anesthesia (23.4 %), fissure sealant (30.7 %) and sedation technique (36.2 %), respectively. Acceptance of fluoride gel and sedation by mothers was significantly higher than fathers (P <0.05). No statistically significant difference was observed in terms of the age and gender of the child with the acceptance of treatment by their parents (P<0.05).
Conclusion: Based on the findings of the present study, the most and the least acceptable treatments according to parents were pulp therapy and general anesthesia services, respectively. Parents' level of education, monthly income, child's age،, and gender did not have a significant impact on parents' acceptance of treatment.
Aabbas Falah Tafti, Mohammad Reza Hakimi Meibodi, Mahammad Safari Khoramabadi,
Volume 33, Issue 4 (7-2025)
Abstract
Introduction: The academic setting and the educational process in dental school can be inherently stressful. Therefore, the aim of this study was to investigate the stressors in the educational setting from the perspective of dental students at Yazd Dental School.
Methods: This descriptive-analytical cross-sectional study was conducted in 2021 among clinical-year dental students at Yazd University of Medical Sciences. Demographic information and stress levels across different areas were gathered through the Dental Education Stress Questionnaire. Data were analyzed using SPSS software version 16 with statistical tests including t-tests, analysis of variance (ANOVA), and Pearson’s correlation coefficient all at a significance level of 0.05.
Results: Among the 240 students who participated, 62.9% were female. The mean total stress score for all students was 80.17 ± 13.7 out of 132. Forty percent of students indicated experiencing high stress, 59.2% reported moderate stress, and merely 0.8% showed low stress levels. No significant differences were identified in the overall stress score or across domains when analyzing gender, parental education, or year of admission (P > 0.05). The overall stress score and the academic efficiency domain were significantly reduced in native students (Yazd residents) compared to non-native students (P = 0.048 and P = 0.016, respectively). No significant differences were observed in other domains (P > 0.05).
Conclusion: The findings of this study indicate that stress levels in the dental setting was moderate to high among most students, with the clinical education aspects being the primary source of stress. Residency status (native vs. non-native) was the only demographic factor that significantly decreased students’ stress levels.
