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Showing 3 results for Farzanegi
The Effect of 8-week Aerobic Exercise with Purslane Supplementation Consumption on Peroxidant and Antioxidants Indicators in Women with Type 2 Diabetes
M Fakoori Jouibari, P Farzanegi, Ar Barari,
Volume 22, Issue 1 (Mar-Apr 2014)
Abstract
Introduction: Influence of physical activity with supplement consumption on the decrease of free radicals effects is not well known during exercise. Purslane is one of the richest sources of omega-3 fatty acid. Thus, the purpose of this study was to investigate the effect of 8-week exercise with Purslane consumption on peroxidant and antioxidants indicators (MDA, SOD, CAT) in women with type 2 diabetes. Methods: 28 sedentary women with type 2 diabetes participated in this study with average age of 50 years and with no history of regular exercise that were randomly divided into 4 groups: control (C), exercise (E), supplementation (S) and exercise + supplementation (E+S). Training programs were 60-75 minutes of aerobic exercise, 3 times in week with 50-70% of maximal heart rate. S and E+S groups consumed 5gr of Purslane seeds with lunch and performed aerobic exercise after 3 hours. Also, 2/5 gr Purslane was consumed with dinner. Blood samples were taken in two phases (before and after 8 weeks) following 12 to 14 hours of being fasted. Results: MDA decreased significantly, but SOD and CAT levels increased significantly in E, S, E+S groups after 8 weeks (P> 0/05). Also there was a significant difference between MDA in E and E+S groups after 8 weeks (P=0/015). Conclusion: The results showed that regular aerobic exercise with Purslane consumption can improve peroxidant and antioxidant balance in women with type 2 diabetes and prevent exercise-induced oxidative stress and also diabetes.
Effect of Six Weeks of Endurance Training and Aloe Vera on COX-2 and MMP-9 Levels in Mice with Breast Cancer
Ar Barari , M Mojhde , P Farzanegi , M Ghasemi ,
Volume 24, Issue 1 (Apr 2016)
Abstract

Introduction: The aim of this study was to determine the effects of six weeks of endurance training and aloe vera consumption on COX-2 and MMP-9 levels in with breast cancer.

Methods: This is an experimental study. 35 BALB/c mice were randomly divided into 5 groups: control (healthy), control (cancer), training (cancer), aloe vera (cancer) and aloe vera + training (cancer). Induction of breast cancer tumors were done in mice by implantation  method. The training groups performed a swimming endurance training for 6 weeks, Aloe Vera group consumed Aloe Vera for 6 weeks to the amount of 300 mg/kg of body weight via intraperiotoneal injection and the control group were kept in cages for 6 weeks. Sampling was performed 48 hours after the last training session. To determine the changes between the groups, one way ANOVA was used and if the changes were meaningful the Tukey's test was used.

Results: The data analysis showed that six weeks consumption of Aloe Vera extract made a significant decrease in the level of cyclooxygenase-2 in mice with breast cancer. Also, a significant reduction in the amount of extract group (Cancer) compared to the controls (cancer) was observed. There was found a meaningful decrease on the matrixmetalloproteinase values in the endurance group and consumer groups of  Aloe Vera extract in mice with breast cancer after 6 weeks of training. In addition, significant reduction in Matrix metalloproteinase levels in the training group (cancer) and extract group (Cancer) compared to the controls (cancer) was observed.

Conclusion: The results of the present study showed that the induction of the cancerous tissue into the mice caused increased levels of COX-2 and MMP-9 values. This increasing is the early symptoms of breast cancer. It also seems that endurance training and Alovera extract can reduce the levels of COX-2 and MMP-9.


Effect of Endurance Training and Stem Cell on Fgf2 and Mmp13 Gene Expression in Knee Tissue of Rats with Osteoarthritis
Mahnaz Alinejad, Alireza Barari, Asieh Abbasi Daloii, Parvin Farzanegi,
Volume 29, Issue 3 (5-2021)
Abstract
Introduction: The aim of this study was to investigate the effect of endurance training and stem cell injection on FGF2 and MMP13 gene expression in knee tissue of rats with knee osteoarthritis.
Methods: The type of study was an experimental one.Male Wistar rats were randomly divided into 5 groups: control - healthy, control - patient, patient - stem cell, patient - training, and patient - training - stem cell. The training program consisted of 30 minutes of running on a treadmill with no slope at 16 m / min for the first week, with 1 m / min added weekly. Rats received MSCs through intracellular injection of 1*106 cells / kg. Expression of FGF2 and MMP13 genes was measured by Real Time PCR. One way ANOVA and if there was a significant difference, Tukey post hoc test were used to determine the difference between groups. All statistical analyzes were performed using SPSS version 16.
Results: Data analysis showed that training and stem cell therapy have significantly increased in genes expression of FGF2 and MMP-13 in mice with osteoarthritis (p <0.000). Moreover, Tukey post hoc test showed a significant difference in the level of FGF2 changes in the training-stem cell groups compared to the training group and the saline group (p=0.000‌). There was also a significant difference between the MMP-13 follow-up test with the control group with the saline group, the training group and the stem cell with the train-stem cell, and the saline group with the training group9(P=0.000‌).
Conclusion: The results showed that FGF2 levels and MMP13 in the cartilage tissue of mice with osteoarthritis have increased and endurance training and stem cells therapy caused a decrease in the level of factors.

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