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The Protective Effect of Aloe Vera on Histological Structure of Endocrine Portion of Pancreas Gland in the Diabetic Rat
N Erfani-Majd , N Sadeghi, Sh Hosseinifar,
Volume 23, Issue 10 (Jan 2016)
Abstract

Introduction: Since aloe vera plant has many medical benefits, the present study aimed to investigate the protective effects of Aloe vera gel on the pancreatic islets and beta cells.

Methods: This experimental study consisted of 50 mature male rats aged 2-3 months and weighed 200-250 g, who were randomly divided into five groups (n=10). Group I (control) did not receive any treatments, and group II were diabetized via Streptozotocin (IP) in 65 mg/kg, whose blood sample was taken after one week. Rats with blood glucose more than 250 mg/dL were considered as diabetic. Group III diabetic rats received the Aloe vera gel daily with dosage of 400 mg/kg, and group IV diabetic rats received insulin in 10 units/rat. Group V involved healthy rats which received only Aloe vera gel. After the last Aloe vera gel administration, blood glucose and body weight of all groups were measured on 15th and 30th days. Animals were euthanized with ether. Then tissues samples were collected from pancreas gland and fixed in 10% neutral buffered formalin solution. The 5-6 µ sections were made by paraffin embedding method and stained using haematoxylin-eosin (H&E) and Aldehyde fuchsin stains. Ultimately, the histomorphometrical parameters were evaluated.

Results: The mean number and size of pancreatic islets and beta cells of Langerhans islets decreased significantly in the diabetic group compared to the control group. The number of beta cells and diameter of langerhans islets increased significantly in the rats treated by Aloe vera gel in comparison to diabetic group at the end of 15th and 30th days.

Conclusion: Applying Aloe vera gel seems to improve the renewal and restoration of langerhans islets and beta cells of pancreas gland in the diabetic rat.


Study of Okra Powder (Abelmoscus Esculentus) Effects on Histology of Liver Tissue and Sero-Biochemical Parameters in Diabetic Rats (HFD/STZ)
N Erfani Majd, A Shahriari, Mr Tabandeh, Z Soleymani,
Volume 24, Issue 9 (Dec 2016)
Abstract

Introduction: Type 2 diabete is a kind of metabolic disease that it is associated with hyperglycemia, hyperlipidemia and disturbed liver function.  The aim of the present study was to evaluate the protective effects of Okra Powder on liver damage in high fat diet fed / streptozotocin (HFD-STZ)-induced type 2 diabetic rats.

Methods: In this experimental study, 25 Wistar Albino female rats with an average weight of (200–220 g) were randomly divided  into 5 groups: Group I: (control group) rats were fed the standard diet, Group II: healthy rats that received Okra Powder (200 mg/kg) for 4 weeks; Group III (HFD/STZ group): Rats were fed with high-fat diet (HFD) (60% fat) for 4 weeks  and then injected low dose of STZ (35 mg/kg), Group IV:  Diabetic rats that received Okra Powder (200 mg/kg) for 4 weeks. GroupV: Diabetic rats that received metformin (200 mg/kg) for 4 weeks. At the end of experiment, biochemical parameters were measured. Liver samples were removed and 5-6 µ sections were made and stained by H&E and Sudan black staining.

Results: The results showed that all the biochemical parameters, except HDL-C and serum insulin were increased in diabetic rats, while they were decreased in Okra supplementation group compared  to diabetic rats (p<0.05). The liver structure alterations were improved in treated diabetic rats with Okra Powder and metformin. 

Conclusion: Our findings confirmed the potential anti-hyperglycemic and hypolipidemic effects of Okra Powder. Thus, it seems it has an important role in the management of type 2 diabete.


The effect of S-ketamine administration on improving memory and learning following cerebral ischemia and reperfusion in male Wistar rats
Seyedeh Mahdieh Khoshnazar, Sohaila Erfani, Reza Sinaei,
Volume 32, Issue 12 (3-2025)
Abstract
Introduction: This study investigated the effect of S-ketamine administration as a neuroprotective treatment for necrotic cell death and memory and learning impairments following a cerebral ischemia model in male rats.
Methods: In this experimental study, 28 male Wistar rats with weighing between 250-300 g, were randomly divided into four groups: Sham, Ischemia-Saline, Ischemia-S-ketamine (low dose), and Ischemia-S-ketamine (high dose).In the ischemia groups receiving low and high doses of S-ketamine, the drug was administered immediately right after the onset of ischemia at doses of 0.1 mg/kg and 0.25 mg/kg body weight, respectively. Memory and learning were evaluated in the different groups through the passive avoidance learning test. Four days after induction of ischemia, necrotic cell death was measured using Cresyl violet staining. Data were analyzed using SPSS software.
Results: The results showed that in the ischemia-saline group, significantly increased in the number of necrotic cells compared to the sham group (p<0.05). Treatment with S-ketamine substantially decreased necrotic cell death in the CA1 region of the hippocampus. The reduction in ischemia-induced cell death was more significant in the high-dose S-ketamine treatment group compared to the low-dose S-ketamine treatment group (p<0.05). Moreover, S-ketamine treatment improved memory and learning deficits caused by ischemia in a dose-dependent manner.
Conclusion: Treatment with S-ketamine has been able to affect the consequences of cerebral ischemia, and therefore the introduction of S-ketamine therapy is proposed as a new therapeutic method in the treatment of cerebral ischemia.
 

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