Bahram Jamali Qarakhanlou, Abbas Ebrahimi Kalan, Asghar Tofighi,
Volume 25, Issue 6 (Aug 2017)
Abstract
Introduction: Coronary heart disease is the most common cause of myocardial ischemia. The present study was aimed to evaluate the effect of resveratrol and aerobic exercise together and singularly on some cardiovascular risk factors in rat model of acute heart failure due to isoproterenol application.
Materials and Methods: In this experimental study, 46 male Wistar rats were divided into five groups randomly as follows: the healthy control (CON), isoproterenol induced myocardial infarction without implementation (ISO), resveratrol treated rats (ISO+RES), exercise treated rats (ISO+EXE) and combination of resveratrol and exercise groups (ISO+RES+EXE). Rats in the resveratrol groups received daily dose of 25 mg/kg/bw of resveratrol and exercise groups ran 1 h/d and 8 weeks on treadmill. Subsequently, all animals received subcutaneous isoproterenol on two consecutive days at the end of experiment. Then, animals anesthetized and blood samples were collected for analysis.
Results: The results showed that pretreatment with a combination of resveratrol and aerobic exercise led to a significant reduction in troponin-I in the animals. Also, exercise training, resveratrol and combinations of them were prevented the increasing CRP indices, but there was not significant effect in these groups (P> 0.05). Pretreatment with exercise training as well as combination of resveratrol and exercise training caused a significant decrease serum cholesterol and triglyceride levels were compared to the isoproterenol group (P≤ 0.001). Pretreatment with resveratrol, exercise training and a combination of both significantly increased in HDL-C and pretreatment only in mixed group led to significant decrease in LDL-C compared to the isoproterenol group (P= 0.001).
Conclusion: Regular exercise and resveratrol supplementation is likely to be effective on cardiovascular risk factors and the combination of the two variables in the prevention of inflammation and will have a significant role in heart damage caused by myocardial infarction
Ali Ghaffarian, Abbas Ebrahimi Kalan, Fatemeh Afshari, Reza Alipanah-Moghadam,
Volume 31, Issue 2 (5-2023)
Abstract
Introduction: The destructive effects of anticancer drugs such as cisplatin are well known. In recent years, it has been found that medicinal plants have a fundamental role in protecting the damage caused by drug. The purpose of this study was to investigate the effects of vaccinium arctostaphylus plant one of the prevalent materials in traditional medicine in improving the disorders caused by cisplatin in testicular tissue.
Methods: In this research, forty rats were divided into 5 groups (G) (n=8) based on administration cisplatin and extract of vaccinium arctostaphylus. In G1 physiological serum was injected and in G2 only cisplatin was administrated. In G3, G4, and G5 Arctostaphylus vaccinium extract with a concentration of 100, 200, and 300 mg/kg along with a single dose of cisplatin were administrated. After 24 hours, the rats were sacrificed, and then testis was isolated and subjected to histopathological evaluation with t-test and one-way ANOVA test on Prism-GraphPad 9.
Results: Our results showed that in the G2 group, the number of spermatogonial cells was reduced compare with G1 (P=0.01); As well as the thickness of the germinal epithelium and the diameter of the seminiferous tubules were reduced partially. In G3 and G4 groups in comparison with G2, the germinal epithelium was improved (P=0.02). The preservation of spermatogonial cells in G3 significantly increased compare with G2 (P=0.01).
Conclusion: According to the results, Arctostaphyllus vaccine as a native plant in defined dosages has a significant effect on improving cisplatin-induced disorders in the germinal epithelium and the number of spermatogonial cells preservation.
