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Introduction: Sleep is an organized behavior which is repeated every day as a vital necessity, and based on biological rhythm. Sleep disorders are common problems in pregnancy that it seems to have emotional and psychological consequences in pregnant women. This study investigated the relationship between sleep disorders and depression during pregnancy among primigravidae. Methods: This cross-sectional, analytical study was conducted on 70 primigravidae with gestational age between 36 and 40 weeks, singleton without known disease. Subjects were selected by multi-stage sampling method in Health– Treatment centers of Ahvaz Jundishapour University of Medical Sciences. After filling demographic, Winefield & Tiggemann multidimensional support scale, ENRICH marital satisfaction scale and ISI questionnaires, subjects were classified into two groups: with and without sleep disorders. Then they were evaluated for depression by Beck questionnaire. Using SPSS(ver. 17), data was analyzed by T-test for quantitative variables, and chi square and Fisher test for qualitative variables, and Mann-Whitney test for ordinal variables. Results: Findings showed that the severity of sleep disorders is related to depression in pregnancy(p=0.01). There was a statistically significant relationship between difficulty falling asleep, sleep continuation, early awakening, and disruption of daily activities with depression during pregnancy(p= 0.03, 0.008, 0.03, and 0.001, respectively). Conclusion: With regard to the results, education about healthy sleep and suitable consultation during pregnancy is recommended in order to prevent mental complications and to achieve a safe pregnancy