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Showing 3 results for Afzali
A review on tissue engineering scaffolds and their function in regenerative medicine
Maede Afzali, Mahboubeh Mirhosseini, Hosein Molla Hoseini, Habib Nikukar,
Volume 26, Issue 2 (May 2018)
Abstract
 One of the challenges that medical sciences has long been facing is to find the best therapeutic method for the damaged tissues. The main purpose of tissue engineering and regenerative medicine is the development of biological implant or engineered tissues to repair, regenerate or replace the damaged tissue and maintain the organ function. At the moment, a lot of research has been done in the field of nanotechnology on the application of nanomaterials in medicine, because the surface of these nanomaterials increases with decreasing their size with change or increases in effect concommitantly. In recent decades, the production of medical textiles (Including nano fibers) has been provided good services to the regenerative medicine. In the field of biomedical applications, it is often necessary to combine biological and medical sciences with materials science and engineering. One of the most important application of tissue engineering is the usage of nanofiber matrix as scaffolds for the cell growth and proliferation. In this paper, various types of engineered scaffolds and their functions have been presented and evaluated.
 
Change in the Expression of BAK، FAS، BAX، TNF-A، BCL-2 and Survivin Apoptosis Genes of the Human Breast Adenocarcinoma Cells (MCF-7) by Staphylococcal Enterotoxin B
Sara Afzali, Abbas Doosti, Mansour Heidari, Nahid Babaei, Parvaneh Keshavarz,
Volume 27, Issue 6 (10-2019)
Abstract

Introduction: Breast cancer is one of the most prevalent malignancies among women. Patients whose suffering from this condition, as a result of the use of conventional therapies often have a poor response to treatment and the relapse among them is frequent. In this study, the effects of staphylococcal enterotoxin type B on BAK، FAS، BAX، TNF-a، BCL-2 و Survivin genes expression in human breast adenocarcinoma cells (MCF-7) was examined. Staphylococcal enterotoxin B is a powerful member of the Staphylococcus aureus toxins family, which is known as an anticancer agent with potential for killing cancer cells.
Methods: The experimental study was carried out at the Biotechnology Research Center of Islamic Azad University, Shahrekord Branch. By using Lipofectamine 2000 reagent, MCF-7  cells transfected with the pcDNA3.1(+)-seb (recombinant) and  pcDNA3.1(+) (non-recombinant)  plasmids and were selected by culturing in a selective medium of RPMI- 1640 containing 600 μg / mL antibiotic G418. Then, the expression of BAK, FAS, BAX, TNF-a, BCL-2, and Survivin genes in transfected cells were analyzed by real time PCR. Student's t-test, SPSS Inc., Chicago, IL; Version 16 and also Excel program for statistical analysis were used.
Results: The results of this study indicated that staphylococcal enterotoxin type B (SEB) remarkably changes the expression of apoptotic related genes in MCF-7 cell line. It was observed a significant increase in the expression of BAK, FAS, BAX, and TNF-a genes, the expression of BCL-2 and Survivin genes significantly decreased compared to the control group (P=0/032).
Conclusion: Staphylococcal enterotoxin type B has an inhibitory effect on the growth, proliferation and invasion of breast adenocarcinoma cells through altering the expression of the genes involved in the apoptosis process. Therefore, it seems that there is a good research field for the use of this toxin in the control and treatment of human breast adenocarcinoma.
 


A Survey of Alcohol Poisoning and Disinfectants Cases in Patients Referred to Hospitals in Yazd Province during the Covid-19 Epidemic (First Wave of the Disease)
Ahmad Dehghan, Fatemeh Sadeghi, Fatemeh Afzali,
Volume 29, Issue 11 (2-2022)
Abstract
Introduction: Alcohol and beverages are one of the challenges in the field of hygiene and health today. By increasing the number of people suffering from covid-19 cases of alcohol and disinfectant poisoning increase and the reason was rumors spreading all over the country at the beginning of covid-19 prevalence. The aim of this study was to survey of alcohol poisoning and disinfectants cases in the patients referred to hospitals in Yazd Province during the Covid-19 epidemic.
Methods: This descriptive-analytical cross-sectional study was performed on 101 patients with alcohol poisoning who were admitted to hospitals affiliated to Yazd University of Medical Sciences during the prevalence of covid-19. Sampling was completed by census and information using the standard questionnaire of the Passive Defense Department of the Ministry of Health. Data analysis was performed using independent t-test and Chi-square and also with SPSS 16 software. The significance level was 0.05.
Results: The mean age of 101 patients was 26.07± 7.33 years. 88.1% of patients were male, 58.4% were single and 42.6% had a diploma. 88.51% of the patients obtained their alcohol through peddlers and 47.5% of patients used alcohol to achieve happiness. 59.4% of the patients had no complication-free recovery, 12.9% had improvement with vision problems and 22.8% had other cases.
Conclusion: Given that the covid-19 pandemic will continue, the most important action is to educate families and society about the dangers of alcohol poisoning its long-term effects and mortality, as well as the wrong misconception about effectiveness of alcohol in prevention and the last word in to authorities to pay more attention to public health and strategic planning to prevent It is from the prevalence of methanol.

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