Showing 2 results for مهدیان
M Behrashi, M Mahdian, Ga Mosavi, Sh Aghdaee,
Volume 16, Issue 3 (Autumn 2008)
Abstract
Introduction: The purpose of this study was to compare the efficacy and side effects of two different misoprostol regimens for second-trimester pregnancy termination.
Methods: 60 consenting women who were at 14 to 28 weeks of gestation with indications for pregnancy termination were randomly assigned to two equal groups to receive either vaginal or oral misoprostol. The dosing regimen was 400µg as the initial dose followed by 400µg and up to 3 doses (1200µg) if needed in each group. Efficacy and side effects were compared.
Results: 30 patients randomly assigned to vaginal and 30 to oral misoprostol group. Demographic characteristics were similar in both the groups. The percentage of women who delivered was significantly higher in vaginal group than the oral group (86.7 vs.43.3, P=0.0006).The average induction to delivery interval was shorter in vaginal group, but this difference was not significant (9.7±4.2 vs. 12.7±7.3 P=0.083). No significant differences in complication rates or side effects were noted between the two groups.
Conclusion: Vaginal administration of misoprostol resulted in a higher success rate for second trimester pregnancy termination, whereas, no significant differences in induction to delivery time and complication rates were noted between vaginal and oral groups.
S Madani, Sh Shahbazi, R Mahdian, J Alizadeh, Z Salehi,
Volume 21, Issue 6 (Jan-Feb 2014)
Abstract
Introduction: Aquaporins (AQPs) are water channels present in the cell wall, allowing water – and occasionally other molecules – to pass the cell membrane. Their function is to maintain the internal milieu cells by regulating water and ion equilibrium. The endometrium undergoes structural changes during the menstrual cycle. If implantation does not occur at the end of each menstrual cycle, amplified endometrium is shed in absence of hormones and leads to bleeding. Excessive uterine bleeding over 80 cc in each menstrual cycle called menorrhagia, is a common gynecological disorder which causes large menstrual bleedings and reduced quality of life for those affected.
Methods: The study included 37 patients with menorrhagia and 20 healthy individuals. Genomic DNA was extracted from peripheral blood and Genotypes were determined by ARMS-PCR and PCR-RFLP .Statistical analysis was performed using the SPSS program.
Results: Regarding rs1049305, the C minor allele showed more frequency in patients' group (0.47 vs. 0.37). The results revealed that GG genotype presents less probable risk for menorrhagia. rs10244884 also shows the same frequency.
Conclusion: It can be concluded that both variants are important in pathogenesis of menorrhagia and the results confirm the important role of Aquqporin–1 channel in menstruation as well as endometrium physiology.
