Showing 17 results for جلالی
N Parsaeian , Ba Jalai , M Afkhami ,
Volume 12, Issue 4 (winter 2005)
Abstract
Introduction: Lipoprotein (a) is a particle rich in cholesterol in human plasma and it is known as an independent risk factor for coronary artery disease. In addition to genetic background, other factors such as diabetes affect the plasma concentration of this lipoprotein as a risk factor. The aim of this study was evaluation and comparison of plasma concentration of Lp(a) in type II diabetics and non diabetic individuals.
Material and Methods: The study population included 180 diabetic patients who had referred to the Diabetic Research center of Yazd and 180 non diabetic individuals who were matched according to age and sex with the patient group. Blood samples were collected from the study groups in fasting condition. Glycated hemoglobin, glucose, lipids and lipoproteins were measured by routine laboratory methods and Lp(a) assay was carried out by electro immunodiffusion. Results were analyzed with the use of SPSS program. Statistical tests included variance analysis, t-test for comparing lipids and lipoproteins, U-test for comparing Lp(a) in the two groups and Pearson Correlation for determining of the variables with Lp(a).
Results: Mean plasma concentratin of Lp(a) in diabetic patients (Mean + SD 41.98+ 34.63 mg/dl) was significantly higher than that of the control group (26.6 + 20.2 mg/dl) (P<0.001). Mean concentration of cholesterol, triglyceride and LDL cholesterol in the patient group was higher but mean HDL cholesterol in control group was higher than patient group. However, no significant correlation was found between Lp(a) and other variables in the patient and control groups.
Conclusion: Plasma concentration of Lp(a) in Diabetes Mellitus is increased independently. In diabetic patients, the risk of coronary artery disease may increase with increase in Lp(a).
A Rafati, S Moradi , M Ismaeili Dahadje, B Jalali, P Yaghmayee,
Volume 13, Issue 5 (Winter 2006)
Abstract
Introduction: Serum lipid disorders are one of the important risk factors for development of coronary arterial atherosclerosis. The aim of this study was to compare the effects of the drug lovastatin and a liquid vegetable extract (dill) on blood plasma lipid levels of rats.
Methods: In this experimental study, 32 mouse vistar rats weighing 250±30 grams were included and maintained at 23±1 degrees Celsius. The rats were divided into 4 groups of 8 rats each. Groups I and II were given normal and high cholesterol diet, while groups III and IV were given high cholesterol diet with either lovastatin or seed dill extract for a period of 3 weeks, respectively. At the end of study, blood samples were taken and plasma lipid levels determined by the manual method. (It is worth mentioning that ultimately 26 rats were included in the study groups).
Results: Results showed that both administration of lovastatin and the seed dill extract led to a significant reduction in plasma levels of cholesterol, triglycerides, LDL and LDL/HDL, TG/HDL ratios. There was a significant reduction in the levels of LDL (P<0.001) and also a significant increase in levels of HDL (P<0.001) in both the groups. The effects on plasma triglycerides levels, LDL/HDL and TG/HDL ratios were not significant.
Conclusion: Considering the results of the study, seed dill extract affects plasma lipid levels and is more effective in lowering plasma cholesterol and LDL levels as compared to lovastatin.
N Parsaeyan, Ba Jalali, H Mozaffari,
Volume 16, Issue 3 (Autumn 2008)
Abstract
Introduction: Hyperlipidemia is a risk factor for atherosclerosis and cardiovascular diseases. Nuts such as almonds are high in unsaturated lipids and antioxidants. Some studies indicate that nuts have beneficial effects on cardiovascular system. Therefore, the aim of this study was evaluation of the effectiveness of shelled almonds on reduction of blood lipid and lipoprotein levels in hyperlipidemic patients.
Methods: This study was a clinical trial (before and after) and was done on 30 men volunteering for the study. They consumed 60 grams shelled almonds per day for four weeks. Their blood lipid, lipoprotein, apolipoprotein and lipoprotein (a) levels were measured after and before almond consumption.
Results: Shelled almond consumption caused significant decrease in serum cholesterol 36.1 mg/dl, triglyceride 45.94 mg/dl, LDL-cholesterol 28.68 mg/dl and increase in HDL-cholesterol 10.64 mg/dl(p<0.001). Shelled almond consumption decreased lipoprotein (a) (2.11 mg/dl), apolipoprotein B100 (8.93 mg/dl) and increased apolipoprotein A (1 1.74 mg/dl) levels, but this effect was insignificant statistically.
Conclusion: Continuous consumption of shelled almonds has beneficial effect on blood lipids and may play a preventive role in Atherosclerosis and coronary heart diseases. We therefore suggest that a daily intake of 60 grams of almonds can be used for treatment of hyprelipidemic patients.
A Absalan, T Vakili, Ba Jalali-Khanabadi,
Volume 19, Issue 3 (Jul-Aug 2011 2011)
Abstract
Introduction: Myocardial infarction as a leading cause of death in most populations is associated with blood clot formation in coronary artery, and rapid clot lysis is important for patient treatment. Some reports have indicated the effects of some trace elements on blood coagulation and clot lysis. The aim of this study was to evaluate the effects of zinc, copper and aluminum on in-vitro coagulation and clot lysis by streptokinase.
Methods: The citrated fasting fresh-pooled plasma prepared from healthy individuals was divided to zinc, copper, aluminum and control groups. Calcium chloride and streptokinase were used for induction of plasma coagulation and Fibrinolysis, respectively. Clot formation and lysis were monitored turbidimetrically, and quantitative parameters including lag time for coagulation, clot lysis, time of coagulation and time for half lysis were calculated after plotting a kinetic curve of time versus absorbance. SPSS software and independent t-test were used for statistical analysis.
Results: In comparison with control, addition of zinc reduced lag time of coagulation(216.8±4.4 vs 229.2±2.6 sec, P= 0.001) and copper reduced coagulation time(194.4±3.7 vs 280±3.5 sec, P= 0.001). Addition of aluminum increased lag time for coagulation(563.6±8.8 Sec, P= 0.001), lag time for clot lysis(194±3.6 sec, P= 0.001), coagulation time(484±7 sec, P= 0.001), and time for half lysis of clot (328.4±6.1 sec, P=0.001).
Conclusion: Results indicated that essential trace elements including zinc and copper at low levels do not have important effects on coagulation and fibrinolysis, but aluminum as a toxic element affects these processes and partially inhibits them even at very low levels.
M Rouzrokh, A Jalali, M Samsami, H Zirakzadeh, A Heidari, M Fallah, Z Yekta,
Volume 19, Issue 3 (Jul-Aug 2011 2011)
Abstract
Introduction: Hirschsprung's disease(HD) is a common congenital disease. In 80% of cases, the recto sigmoid junction is involved. Recently, one-stage transanal endorectal pull-through(TAEPT) procedure has been popular, but it could have several complications. In this research, we have studied the complications of this procedure.
Methods: During a four year period, 86 infants clinically suspected to have HD were admitted at our center. HD was confirmed by rectal biopsy and all were candidates for TAEPT operation. A Swenson-like procedure was performed and in 30 cases, prophylactic Hegar dilatation was done 2 weeks after operation.
Results: Anal stricture was seen in 12 cases(14%) of which 10 cases were treated by anal dilation and 2 cases were corrected by surgical management. Entrocolitis was seen in 4 cases(5%) who were treated by medical management. In 2 cases, retrocolic abscess was present that was treated by spontaneous drainage via tube drain. There was no anastomotic stricture after starting prophylactic anal bouginage.
Conclusion: TAEPT has many advantages and few complications. It seems that one of the most common complications is anastomotic stricture that responds well to prophylactic bouginage. We recommend prophylactic anal bouginage with Hegar probe 2 weeks after operation. A long-term follow-up is needed to evaluate the outcomes of these operations.
B Talaei, H Mozaffari-Khosravi , Ba Jalali , M Mahammadi, A Najarzadeh, H Fallahzadeh,
Volume 20, Issue 3 (Jul-Aug 2012)
Abstract
Introduction: Nowadays there is an uprising trend toward new approaches in type 2 diabetes management. In this study the effect of ginger supplementation on blood glucose, lipid and lipoproteins was examined in diabetic patients. Methods: 81 patients with type 2 diabetes participated in this randomized clinical trial study within two-month interval. Patients were randomly divided into two groups: Placebo (PG) and supplemented (SG). SG group were supplemented with 3 capsules (1g ginger powder in each capsule) and PG group received 3 microcrystalline cellulose capsules each day. Fasting blood glucose(FBS), fructose-amine, HbA1c, total cholesterol, triglycerides, LDL-c, HDL-c and Apolipoproteins (Apo) A1 and B100 were measured before and eight weeks after intervention. Results: Mean of LDL-c in SG before and after supplementation were 112.52 ± 22.09 and 106.10±20.78mg/dl(P=0.03), respectively. Also the results showed significant difference in levels of Apo A1 in SG and PG in the beginning and end of trial(P‹0.005). However no significant differences between groups were observed. Moreover no significant disparities were observed in level of Apo B100, total cholesterol, triglycerides and HDL-c at the same period in studied groups. Mean FBS level after intervention in SG showed a 10.5% decrease(P=0.003), meanwhile a 21% increase in PG (P=0.01) was reported. Changes in mean HbA1c had a similar trend with mean FBS. Conclusion: This study indicates that ginger supplementation for type 2 diabetic patients would improve LDL-c, APO A1, fasting plasma glucose and HbA1c parameters
M Bahrami, Z Afshari, F Ahmadi, Mj Mohiti, Ba Jalali-Khanabadi, A Moradi,
Volume 21, Issue 3 (Jul-Aug 2013)
Abstract
Introduction: Phenolic compounds have an important role as essential metabolites for plants growth and reproduction, as well as protecting agents against pathogens. These compounds are important sources of antioxidants which act as reducing agents and hydrogen donors. Consumption of fruits, vegetables and plants rich in poly phenols is associated with the reduced risk of certain cancer, cardiovascular, diabetes and Alzheimer’s diseases. Curcuma langa or Turmeric is a tropical plant that natively grows in South and Southeast Asia. This plant has been used as a spice as well as a herbal drug in traditional medicine in India. Recently, many studies have been conducted on the medical effects of this plant and still some researches are ongoing. Turmeric possesses a wide range of biological and pharmacological activities including antioxidant, anti-inflammatory and anti-carcinogenic effects. It seems that pharmacological activities of turmeric is related to poly phenolic compounds existing in this plant.
Methods: This study was performed on the hydroalcoholic extract of the turmeric rhizome experimentally with a repetition of several times. Results of this study were presented via means±SD. In the present research poly phenolic contents of turmeric extract was evaluated using tannic acid standard.
Results: The study findings demonstrated that 1µg hydroalcoholic extract contains 0.59±0.051µmoleTAE of poly phenolic compounds.
Conclusion: This study revealed that phenolic contents of turmeric hydroalcoholic extraction is noticeable and it seems that phenolic contents are caused by curcuminoids compounds that exist in this plant.
N Mazlom Bafroe, H Shams Esfand Abadi, Mr Jalali, M Afkhami Ardakani, A Dadgari,
Volume 23, Issue 2 (Apr-May 2015)
Abstract
Introduction: Psychological and behavioral domains involve important issues in coping with diabetes. Therefore, this study was conducted in order to investigate the relationship between resilience and hardiness in patients with diabetes 2 in Yazd.
Methods: This study is a descriptive-correlation study which the sample consisted of 310 diabetic patients (160 women and 150 men). In order to glean the study data, Caner and Diveson psychological resilience and Ahvaz psychological hardiness questionnaires were applied. Data analysis was performed via SPSS18 software utilizing Pearson correlation and independent T-test.
Results: The study results indicated that a significant correlation was observed between resilience and hardiness in each group as well as within all patients with diabetes. Comparing the means of the two groups in regard with resilience and hardiness, it was demonstrated that the differences between men and women with respect to hardiness was significant (t=3/19, p=0/04), though the means of the two groups for resilience was not significant.
Conclusions: Regarding the positive relationship between hardiness and resilience, it could be expected that employing proper treatment in order to increase resilience and hardiness in diabetes, will lead to a decrease in perception of psychological problems, as well as an increase in quality of life.
Hanieh Saramad, Farah Farokhi, Gholamreza Najafi, Ali Shalizar Jalali,
Volume 25, Issue 10 (Jun 2018)
Abstract
Introduction: It has been shown that mobile radiations (MRs) have detrimental effects on brain histoarchitecture and vitamin E as a powerful antioxidant can exhibit neuroprotective effects. This study was carried out to evaluate the protective effects of vitamin E against MRs-induced histological changes in rat brain.
Methods: Adult female Wistar rats were randomly categorized into 4 groups (n₌6), including untreated control, experimental group1 (14 days exposure to mobile calls, 12 times every day and each time for 10 minutes by Huawei H30–U10 cell phone and then, sampling on day 15), experimental group2 (14 days treatment and then, sampling after 40 days) and experimental group3 (radiation + vitamin E 100 mg/kg intramuscularly before MRs exposure).
Results: MRS-treatedrats showed significant reduction in body weight with an increase in brain relative weight. Moreover, MRS resulted in oxidative stress in brain tissue as well as increase in numbers of neurons with pyknotic nuclei in rats hippocampus. Interestingly, vitamin E co-administration led to oxidative stress suppression in brain tissue and nuclear pyknosis reduction in rats hippocampus.
Conclusion: Vitamin E can attenuate MRs- induced histological alterations and oxidative stress in rat hippocampus probably due to antioxidant activities.
Sakineh Falahati, Farah Farokhi, Gholamreza Najafi, Ali Shalizar Jalali,
Volume 26, Issue 1 (Apr 2018)
Abstract
Introdution:. Increased plasma cholesterol causes hepatic damages through oxidative stress (OS) induction. There are many investigations about hawthorn effects on lipid reduction and atherosclerosis. The goal of current study was to determine the effects of hydro-alcoholic extract of Crataegus aronia fruit (HECA) and atorvastatin (AVS) on hypercholesterolemia-induced alterations in serum lipid profile and OS in hepatic tissue of female rats.
Methods: In this experimental study, 42 female rats were assigned into 7 groups including control, diet-induced hypercholesterolemia (DIH), DIH + HECA (200 mg/kg/day; Per Oral (PO)), DIH + HECA (400 mg/kg/day; PO), DIH + AVS (10 mg/kg/day; PO), HECA (200 mg/kg/day; PO) and AVS (10 mg/kg/day; PO). After 30 days, blood and hepatic tissue samples were collected for biochemical and histological analyses. Data were analyzed by one-way ANOVA and Tukey's statistical tests using SPSS software.
Results: Hypercholesterolemia resulted in significant increases in levels of serum lipids, hepatic enzymes and malondialdehyde in hepatic tissue as well as reductions in total antioxidant capacity and catalase level in liver compared to control group. Moreover, DIH led to significant increases in diameters of hepatocytes and their nuclei along with inflammation and cellular necrosis in hepatic tissue. Administration of HECA and AVS significantly restored above-mentioned parameters compared to DIH group.
Conclusion: These findings suggest that HECA can play a protective role against hepatic damages in hypercholesterolemic female rats According to the results of this study, the prevalence of obesity is not high in female students (3 %), but it is necessary to pay particular attention to information on obesity and girls' sports in universities, so that the prevalence of this disease is not increased
Hakimeh Sadeghian, Reza Mohseni-Badalabadi, Sorya Arzhan, Fahimeh Abdollahi, Arash Jalali, Mohamad Sahebjam, Arezo Zourofian, Ali Hosseinsabet,
Volume 26, Issue 4 (Jun 2018)
Abstract
Introdution: Ischemic mitral regurgitation (IMR) remains one of the most complex and unresolved aspects of ischemic heart disease that the impact of percutaneous coronary intervention (PCI) on improvement of intensity of ischemic mitral regurgitation is not well clarified. Patients with coronary artery diseases and ischemic mitral regurgitation have a worse prognosis than the patients with coronary artery disease (CAD) and those without ischemic mitral regurgitation. We sought to investigate the impact of complete revascularization by percutaneous coronary intervention PCI on improvement of IMR in patients with CAD and comparisons of echocardiography indices in patients with and without improvement of ischemic mitral regurgitation.
Methods: In this cross sectional retrospective study, echocardiographic reports in pre- percutaneous coronary intervention time and 12 months after PCI of patients with moderate (≥2+) ischemic mitral regurgitation who underwent complete revascularization by percutaneous coronary intervention from Farvardin 1391 to Esfand 1393 were included in the study. Then, echocardiographic data of the patients with improved ischemic mitral regurgitation compared with the patients with non-improved ischemic mitral regurgitation.
Results: Comparison of echocardiographic indices before and after percutaneous coronary intervention revealed that after percutaneous coronary intervention (P = 0.002) in 15 patients (16%), improvement in ischemic mitral regurgitation was occurred. Also, left ventricular ejection fraction (P = 0.010), left ventricular end- diastolic (P = 0.003) and end-systolic diameters (P < 0.001), wall motion score index (P = 0.003), left atrial area (P = 0.001) and systolic pulmonary artery pressure (P = 0.046) in pre- percutaneous coronary intervention echocardiography were different between improved and none-improved IMR group.
Conclusion: Although, percutaneous coronary intervention can lead to improvement of ischemic mitral regurgitation but most patients did not show improvement of ischemic mitral regurgitation after percutaneous coronary intervention. The structural abnormality of left ventricle and atrium were different between improved and none-improved IMR group
Azarmidokht Jalali Jahromi, Mahboubeh Mirhosseini, Hosein Molla Hoseini, Habib Nikukar,
Volume 28, Issue 1 (5-2020)
Abstract
Introduction: Bone is one of the tissues that have a true potential for regeneration. However, sometimes the bone defects are so outsized that there is no chance of bone self-repair and restoration or the damage is such that it is not possible to repair with medical or surgical interventions. In these situations, bone grafts are the treatment of choice, but due to several obstacles, including limitation in graft preparation and immunological incompatibility, bone grafts face some limitations. In these cases, with the help of regenerative medicine, the bone damages could be repaired. Regenerative medicine provides a new approach for large bone defects by cell therapy and tissue engineering. As, sometime the damaged tissues are so wide that there is no chance of self-repair, the engineered structures help to accelerate the tissue natural repairing. This review focuses on the importance of stem cells and scaffolding for bone tissue engineering. Also, the important characteristics of bone tissue engineered scaffolds like structure, porosity, stability, surface chemistry, bone induction and different met hods of scaffold fabrication are discussed. Up to now, various natural and synthet ic compounds were used for bone tissue engineering, including biopolymers, which are categorized to natural, synthet ic and ceramics. Bioceramics work as effective compound scaffolds in bone tissue engineering. From them bioglasses are one of the important materials which enhance the attachment, proliferation and differentiation of bone cells. Therefore, the current paper discussed biopolymers, as the effective compounds for regeneration of bone tissue.
Nabiallah Khoonmirzaie, Mohammad Razi Jalali, Ali Sahriari, Mohammad Reza Tabandeh,
Volume 28, Issue 1 (5-2020)
Abstract
Introduction: The bacterial Asparaginase is used in the treatment of asparagine-dependent tumors, particularly lymphatic sarcoma and acute lymphoblastic leukemia. However, the instability of the enzyme increases the number of injections that are accompanied by high immune responses. The aim of this study was to investigate the conjugation of L-asparaginase with nanochitosan glutaraldehyde (NCG) derivative and its effect on the physichochemical properties of conjugated enzyme.
Methods: In this experimental study, nanochitosan was synthesized using reduction method with acetic acid and its physicochemical properties were evaluated using transmission electron microscopy and particle size analyzer. Activated NCG derivative was produced using 3% acetic acid. The conjugation of NCG derivative to L-asparaginase was performed with different molar ratios of enzyme/nanochitosan (1:2, 1:5, 1:10 and 1:20) in the presence of sodium cyano borohydrate; and the ratio with the highest residual activity was used for physicochemical evaluation. The activity of enzyme at different temperatures and pH, its half-life and stability after freezing and resistance to proteolysis were analyzed through repeated measure analysis of variance using SPSS 18 software.
Results: The results of this study showed that the conjugation of L-asparaginase with NCG derivative resulted in maintaining the 70% enzyme activity. The activity of conjugated enzyme was higher than native enzyme after freezing and trypsin treatment. The optimum pH and temperature of conjugated enzyme did not change, while it had higher activity in wide range of pH and temperature compared with native enzyme.
Conclusion: Conjugation of L-asparaginase with NCG derivative improved physicochemical and stability of enzyme and this method can be used for production of improved L-asparaginase for clinical application.
Fatemeh Jalali, Zahra Kamiab, Shayan Pourghazi, Gholamreza Bazmandegan,
Volume 30, Issue 6 (9-2022)
Abstract
Introduction: Gestational diabetes (GDM) can affect neonatal developmental indicators. The aim of this study was to evaluate and compare the growth process of infants less than 2 years of age with GDM and healthy mothers in Rafsanjan City.
Methods: This cross-sectional study was performed on 208 neonates under 2 years of age from healthy mothers (104 neonates) and GDM mothers (104 neonates) in Rafsanjan City in 2017. Weight, height and head circumference were measured at birth, 6, 12 and 18 months. Fasting serum glucose above 126 mg/dl after 8 hours of fasting was considered as GDM. Data analysis was performed using SPSS 16 software and independent t-test, Chi-square and repeated measures analysis. Significant level was considered 0.05.
Results: The mean age of GDM mothers was 31.8±5.3 and healthy mothers were 29.2±5.5 years. Cesarean delivery was reported in 73.1% of mothers with GDM and in 57.7% of healthy mothers (P = 0.020). Changes in weight, height and head circumference in the two groups at birth, 6 months, 12 months and 18 months after birth had an increasing process that was higher in infants of mothers with GDM (P <0.001).
Conclusion: The process of weight, height and head circumference changes in infants born to mothers with GDM was higher.
Nazanin Heidari, Parisa Rezaei Mofrad, Mohammad Ali Jalali Far, Mohammad Taha Jalali,
Volume 31, Issue 1 (4-2023)
Abstract
Introduction: Due to the pathophysiology of Sickle cell disease (SCD), several treatment strategies have been reviewed so far. One of the strategies is anti-sickling factors. This study was performed to determine the effect of methanolic extract of Cassia Fistula fruit on sickle cell sickling in vitro.
Methods: In this laboratory study, 25 people with sickle cell trait (SCT) ranging in age from 3 to 27 years, and 5 healthy people (as a control) participated. Cassia Fistula was introduced by Dr. Mohammad Taha Jalali to be used in this project. Methanolic extract of Cassia Fistula fruit was obtained by maceration using vacuum distillation (rotary evaporator). Samples with sickle cell trait were examined for sickle cell before and after extract interference, in hypoxic condition. Data analysis was performed by SPSS software version16.
Results: In this study, 64% of the participants were male and 36% were female. Sickling rates in 1:50, 1: 100 and 1: 200 dilutions were 24%, 37.8% and 46.1%, respectively. According to Wilcoxon Test, the rate of sickling in 1: 2 to 1: 100 dilutions was significantly reduced, relative to pre-interference conditions (P <0.05).
Conclusion: In the present study, it was shown that the methanolic extract of Cassia Fistula plant can prevent erythrocyte sickling in vitro, even with a dilution of 1: 100. According to previous studies, this plant has various therapeutic uses and is non-toxic. Therefore, this extract can be further studied in clinical and in vivo conditions as a useful and cost-effective therapeutic drug.
Reza Kiani, Hamid Jalali Fard, Reza Bidaki,
Volume 31, Issue 12 (3-2024)
Abstract
Introduction: Malingering is a differential diagnosis in the field of medical disorders, especially in the field of forensic medicine. In medicine, malingering is when a person imitates a medical or psychiatric disorder with external motivations to gain financial gain or avoid social or occupational duties. In some cases, diagnosing a medical or psychological condition from malingering can be challenging and difficult. In this case report, a patient with a history of multiple hospitalization, neurodevelopmental disorders, and intellectual disability requested to receive injectable Biperiden due to aggression, irritable mood, and neck deviation, and in order to receive it, he deliberately showed neck dystonia. This report aimed to discuss on a neuropsychiatric symptom, after which the patient requested a drug injection to resolve it, in order to differentiate possible diagnoses such as drug complication, factitious disorder, and functional neurological symptom disorder. On the other hand, during the recent searches of similar texts, conflicting results and suggestions have been presented.
Hamid Sedaghat, Farzaneh Taghian, Khosro Jalali Dehkordi, Hasan Naghizadeh,
Volume 33, Issue 4 (7-2025)
Abstract
Introduction: Research indicates that Physiological stress leads to tissue and cellular damage through its disruPtion of antioxidant status in the body. The main objective of this research was to determine the effects of 12 weeks of high-intensity functional training (HIFT) and Ginkgo biloba (Gb) suPPlementation on suPeroxide dismutase (SOD), catalase (CAT) and total antioxidant caPacity (TAC) serum levels in male firefighters of the oPerational division of Yazd City.
Methods: In this semi-exPerimental study, 48 male firefighters were randomly divided into four grouPs: high-intensity functional training (HIFT), high-intensity functional training combined with ginkgo biloba suPPlementation (HIFT+Gb), ginkgo biloba extract alone (Gb), and a control Placebo grouP (P-C). The training Program lasted 12 weeks, with ParticiPants training four times Per week. The ginkgo biloba suPPlement (80 mg) was administered in two caPsules daily after breakfast for the entire 12-week Period. Blood samPles were taken before the start and 48 hours after the last training session. The collected data were analyzed using rePeated measures ANOVA, as well as one-way and two-way ANOVA in SPSS version 16.
Results: After 12 weeks of intervention, SOD, CAT, and TAC in the HIFT (P=0.0001), HIFT+Gb (P=0.0001), and Gb (P=0.0001) grouPs showed a significant increase comPared to the P-C grouP. SOD, CAT, and TAC levels in the HIFT (P=0.0001) and HIFT+Gb (P=0.0001) grouPs significantly rose when comPared to the Gb grouP. SOD, CAT, and TAC levels in the HIFT grouP (P=0.0001) were notably elevated in comParison to the HIFT+Gb grouP. The synergistic influence of HIFT with Gb markedly elevated serum concentrations of SOD, CAT, and TAC (P<0.05). The greatest Percentage of alterations in SOD, CAT, and TAC were noted after the HIFT intervention with Gb
Conclusion: The combined imPact of 12 weeks of HIFT Paired with Ginkgo biloba intake, in comParison to the individual effect of each, significantly enhanced serum levels of SOD, CAT, and TAC while ameliorating oxidative stress conditions in firefighters.
