Showing 4 results for اسفندیاری
A Shams, A Zavaran-Hoseeni, Mr Masjedi, Sh Shah-Gasempoor, M Ryani, N Esfandiari, M Poor-Amiri,
Volume 17, Issue 2 (Spring 2009)
Abstract
Introduction: Natural killer T (NKT) cells are a subset of lymphocytes that express some NK cells properties. NKT cells have a regulatory role in immune responses. Little is known about the potential role of NKT cells in human infectious diseases. The goal of the present study was determination of frequency of Vα24Vβ11 and CD3CD56 NKT cells in tuberculosis patients.
Methods: According to our criteria, three groups were selected for our study: 30 healthy PPD positive skin test reactors, 30 healthy PPD negative skin test reactors, 30 new case active TB patients and 25 Multi-drug resistance Tuberculosis (MDRTB) patients. Frequency of Vα24Vβ11 and CD3CD56 NKT cells in fresh peripheral blood was determined by Flow cytometry.
Results: Frequency of Vα24Vβ11 NKT cells in the new case TB and MDRTB patients as compared to PPD positive healthy donors was significantly decreased (P<0.05), whereas CD3CD56 NKT cell numbers were similar in all groups.
Conclusion: According to our results decrease in frequency of Vα24Vβ11 NKT cells may be related to insufficient immune responses to mycobacterium tuberculosis infection, especially in MDRTB patients.
Neda Ghazavi, Ebrahim Rahimi, Zahra Esfandiari, Amir Shakarian,
Volume 26, Issue 9 (Des 2018)
Abstract
Introdution: The inappropriate nutrition is one of the reasons for non-communicable diseases. Consumption of a variety of sweets with high saturated fatty acids content is associated with an increased risk of cardiovascular disease, non-alcoholic fatty liver, insulin resistance, and so on. This study was conducted with the aim of collecting information on the types and amount of saturated fatty acids in Iranian traditional sweets.
Methods: A total of 369 samples (packed and unpacked) from 23 types of Iranian traditional sweets were randomly purchased from different brands in Isfahan supermarkets and their saturated fatty acid content was measured by gas chromatography.
Results: The total average of the saturated fatty acid content of all samples was 38.6% in total fat. The highest amount was found in Loz (92.4%) and the lowest content was measured in Nan-khormai and cake Yazdi (less than 20%). Most of the samples (80.5%) had 20-50% of saturated fatty acids. Saturated fatty acids of C16:0, C18:0 and C20:0 were found in all samples and C16:0 had the highest total mean of saturated fatty acid (25.9%). The labeling of some sweet products was associated with reduction in their saturated fatty acid content.
Conclusion: Considering the high level of saturated fatty acids in some types of Iranian high consumption sweets, mandatory labeling of traditional sweets in order to enhance the consumer's awareness of the solid fats content as well as the consumer's awareness of the harmful effects of these fats on the body health can be effective in preventing various diseases, including cardiovascular diseases.
Zahra Esfandiari, Mohammad Amin Edalatmanesh,
Volume 27, Issue 9 (1-2020)
Abstract
Introduction: Uteroplacental insufficiency (UPI) causes neurodevelopmental deficits affecting the intrauterine growth restricted (IUGR) offspring. This study aimed to analyze the effects of Gallic acid (GA) on memory deficit and brain-derived neurotrophic factor (BDNF) content in entorhinal cortex of UPI rat models.
Methods: In this experimental study, 40 pregnant Wistar rats were randomly divided into 5 groups, including: control, UPI, UPI+GA100, UPI+GA200and UPI+GA400. For IUGR induction, anterior uterine artery occlusion surgery was carried out on gestation day (GD) 18. From GD15, GA was administrated orally, in 100, 200 and 400 mg/kg BW doses until the birth of their neonates. Spatial and working memories are analyzed by Morris water maze and Y maze at postnatal day (PND) 30, respectively. Then, BDNF cerebral cortex level was estimated using ELISA technique.The data were analyzed through ANOVA and Tukey Post hoc in SPSS software version 16.
Results: A significant decrease was observed in spatial and working memories and BDNF content in entorhinal cortex of UPI group in comparison with the control group (p˂0.05). On the other hand, GA-treated groups showed a significant increase in BDNF content and amelioration of spatial and working memories (p˂0.05).
Conclusion: Fetal growth restrictionafter UPI by decreasingBDNFlevel in entorhinal cortex caused memory deficits in rat’s model. Moreover, neuroprotective effects of GA lead to increased BDNF content and ameliorate cognitive deficits in UPI model.
Hossein Karami, Mehrnoush Kosaryan, Mohammad Naderisorki, Fatemeh Esfandiari, Mobin Ghazaiean, Aily Aliasgharian, Hanie Fallah, Salameh Shakeri, Hadi Darvishi-Khezri,
Volume 31, Issue 6 (9-2023)
Abstract
Introduction: OsteoPenia and osteoPorosis are known to be one of the main comPlications of β-thalassemia major (β-TM). The aim of this study was to determine the factors associated with decreased bone density of these Patients.
Methods: Lumbar and femoral neck bone mineral density (BMD) in β-TM Patients characterized via Dual-energy X-ray absorPtiometry (DXA) to PinPoint the association of iron chelators, diabetes mellitus, serum ferritin above 3000 ng/mL, hemoglobin below 8 gr/dl, using hydroxyurea, liver siderosis and moderate to severe hePatic and cardiac siderosis with BMD. The information was collected from the thalassemia registry in 2019 and statistical analysis was Performed by STATA-13 software.
Results: Out of 1959 ParticiPants with β-thalassemia major registered in the registry, 139 ones (7.09%) had bone mineral density (53 males and 86 females). The Prevalence of abnormal bone density in the lumbar and femoral neck was (52.48 to 47.66) 57.5 and (40.18 to 57.52) 48.85 Percent, resPectively. After adjusting for the effects of Possible interventions, the odds ratio of abnormal bone density in the Patients consuming hydroxyurea and deferasirox were 0.24 (0.03 to 1.73) and 0.25 (0.03 to 1.69), resPectively. The highest odds were 8.21 (0.18 to 360.22), and 6.72 (0.60 to 74.83) for moderate to severe cardiac and hePatic dePosition, resPectively.
Conclusion: The Prevalence of osteoPenia and osteoPorosis is high among thalassemia major Patients. ConsumPtion of hydroxyurea and deferasirox is the most imPortant Protective factor and moderate to severe cardiac and hePatic siderosis are the most imPortant risk factors for abnormal bone density.
