Volume 13, Issue 4 (Atumn 2005)
JSSU 2005, 13(4): 3-7 |
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Ayatollahi V, Behdad S. Evaluation of Intranasal Midazolam as an Anesthetic Premedication in Preschool Children. JSSU 2005; 13 (4) :3-7
URL: http://jssu.ssu.ac.ir/article-1-698-en.html
URL: http://jssu.ssu.ac.ir/article-1-698-en.html
Abstract: (7953 Views)
Introduction: Preoperative psycho emotional preparation of patients is one of the principle purposes of
anesthesia which can be achieved by administration of premedications. Children should receive
premedication before entering the operating room due to their dependence on parents and the fear and
anxiety of separation from parents. Different drugs are administered for this purpose, but considering
children's sensitivity, it is wise to use the most effective and comfortable medication with least side effects.
Midazolam is a rapid onset, short acting and water soluble benzodiazapine which can be administered by oral,
intravenous, intramuscular, rectal or intranasal routes.
The purpose of this study was to evaluate the result of intranasal midazolam administration (0.2 mg/kg ) as a
premedication in children aged 2-6 years.( Min dose and enough time )
Methods: In this randomized prospective study, 100 children aged between 2-6 years old in class ASA 1 and
candidates of surgery were divided into two groups case and control. The control group received several
nasal drops of normal saline, while the case group received 0.2 mg/kg nasal midazolam 20 minutes before
anesthesia induction.
Results: Twenty minutes after administration of the nasal drops, 14% in the control group and 68% in the
case group were alert and calm. (P value=0.0) . Mask acceptance during induction of anesthesia in control
and case group was 14%and 72%, respectively (P value >0.00) The recovery time in the case group was
longer (P value >0.5), but no complications (nausea, vomiting, respiratory and cardiovascular problems)
were seen in either group.
Conclusion: Nasal midazolam with its anxiolytic, tranquilizing effects and no respiratory or cardiovascular
complications is a safe drug and being better than parenteral drugs is acceptable by children.
Keywords: Intranasal Midazolam, Premedication
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